Tryptophan degradation is associated with risk-taking propensity in methamphetamine users with treated HIV infection.

Journal: Journal of neurovirology

Volume: 26

Issue: 5

Year of Publication: 2021

Affiliated Institutions:  Public Health Sciences and Psychology, Department of Public Health Sciences, University of Miami Miller School of Medicine, NW th St. Office , Miami, FL, , USA. Duke University School of Medicine, Durham, NC, USA. University of California, San Francisco School of Medicine, San Francisco, CA, USA. University of Maryland Department of Psychology, College Park, MD, USA. Unviversity of Cape Town Department of Psychiatry and Mental Health, Cape Town, South Africa. Innsbruck Medical University, Innsbruck, Austria. Public Health Sciences and Psychology, Department of Public Health Sciences, University of Miami Miller School of Medicine, NW th St. Office , Miami, FL, , USA. a.carrico@miami.edu.

Abstract summary 

Few studies have examined neuroimmune pathways that could contribute to impulsivity in people living with HIV who use substances. Eighty-four methamphetamine-using, sexual minority men with an undetectable HIV viral load were administered the Balloon Analogue Risk Task (BART), a behavioral measure of risk-taking propensity. We examined the associations between kynurenine/tryptophan ratio and phenylalanine/tyrosine ratio with BART scores using multiple linear regression. A higher kynurenine/tryptophan ratio was independently associated with greater BART scores (beta = 0.25; 95% CI = 0.05-1.23; p = 0.034). The phenylalanine/tyrosine ratio was not significantly associated with BART scores. Findings support the need for further research to elucidate the neuroimmune mechanisms linking tryptophan degradation with impulsivity to catalyze the development novel pharmacologic treatments for people living with HIV who use methamphetamine.

Authors & Co-authors:  Lee Jared J Lee Ji-Young JY Meade Christina S CS Cohn Michael M Chahine Antonio A Dilworth Samantha E SE Magidson Jessica F JF Gouse Hetta H Fuchs Dietmar D Carrico Adam W AW

Study Outcome 

Source Link: Visit source

Statistics
Citations :  Andres T, Ernst T, Oishi K, Greenstein D, Nakama H, Chang L (2016) Brain Microstructure and Impulsivity Differ between Current and Past Methamphetamine Users J Neuroimmune Pharmacol 11:531–541 doi:10.1007/s11481-016-9675-8
Authors :  10
Identifiers
Doi : 10.1007/s13365-020-00841-4
SSN : 1538-2443
Study Population
Men
Mesh Terms
Adult
Other Terms
HIV;Impulsivity;Methamphetamine;Risk-taking propensity;Tryptophan
Study Design
Cross Sectional Study
Study Approach
Country of Study
Publication Country
United States