Challenges and opportunities for neuroimaging in young patients with traumatic brain injury: a coordinated effort towards advancing discovery from the ENIGMA pediatric moderate/severe TBI group.

Journal: Brain imaging and behavior

Volume: 15

Issue: 2

Year of Publication: 2021

Affiliated Institutions:  TBI and Concussion Center, Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA. emily.dennis@hsc.utah.edu. Cognitive Neuroscience Unit, School of Psychology, Deakin University, Geelong, Australia. Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA. Department of Radiology, Loma Linda University Medical Center, Loma Linda, CA, USA. TBI and Concussion Center, Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA. Division of Neurosurgery, University of Cape Town, Cape Town, South Africa. UCLA Steve Tisch BrainSPORT Program, Los Angeles, CA, USA. Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Emma Neuroscience Group, Amsterdam, The Netherlands. H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA. Department of Diagnostic Imaging, Sheba Medical Center, Ramat Gan, Tel-Hashomer, Israel. Department of Psychiatry, University of California, La Jolla, San Diego, CA, USA. Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway. Kennedy Krieger Institute, Baltimore, MD, USA. Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, Los Angeles, CA, USA. Department of Psychology, University of Calgary, Calgary, Alberta, Canada. Department of Pediatrics, Children's Learning Institute, University of Texas Health Science Center at Houston, Houston, TX, USA. Hospital for Sick Children, Neuroscience and Mental Health Program, Toronto, Canada.

Abstract summary 

Traumatic brain injury (TBI) is a major cause of death and disability in children in both developed and developing nations. Children and adolescents suffer from TBI at a higher rate than the general population, and specific developmental issues require a unique context since findings from adult research do not necessarily directly translate to children. Findings in pediatric cohorts tend to lag behind those in adult samples. This may be due, in part, both to the smaller number of investigators engaged in research with this population and may also be related to changes in safety laws and clinical practice that have altered length of hospital stays, treatment, and access to this population. The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Pediatric Moderate/Severe TBI (msTBI) group aims to advance research in this area through global collaborative meta-analysis of neuroimaging data. In this paper, we discuss important challenges in pediatric TBI research and opportunities that we believe the ENIGMA Pediatric msTBI group can provide to address them. With the paucity of research studies examining neuroimaging biomarkers in pediatric patients with TBI and the challenges of recruiting large numbers of participants, collaborating to improve statistical power and to address technical challenges like lesions will significantly advance the field. We conclude with recommendations for future research in this field of study.

Authors & Co-authors:  Dennis Emily L EL Caeyenberghs Karen K Asarnow Robert F RF Babikian Talin T Bartnik-Olson Brenda B Bigler Erin D ED Figaji Anthony A Giza Christopher C CC Goodrich-Hunsaker Naomi J NJ Hodges Cooper B CB Hoskinson Kristen R KR Königs Marsh M Levin Harvey S HS Lindsey Hannah M HM Livny Abigail A Max Jeffrey E JE Merkley Tricia L TL Newsome Mary R MR Olsen Alexander A Ryan Nicholas P NP Spruiell Matthew S MS Suskauer Stacy J SJ Thomopoulos Sophia I SI Ware Ashley L AL Watson Christopher G CG Wheeler Anne L AL Yeates Keith Owen KO Zielinski Brandon A BA Thompson Paul M PM Tate David F DF Wilde Elisabeth A EA

Study Outcome 

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Statistics
Citations :  Acerini CL, Tasker RC (2007): Traumatic brain injury induced hypothalamic-pituitary dysfunction: a paediatric perspective. Pituitary 10:373–380.
Authors :  31
Identifiers
Doi : 10.1007/s11682-020-00363-x
SSN : 1931-7565
Study Population
Male,Female
Mesh Terms
Adolescent
Other Terms
ENIGMA;Moderate-severe TBI;Neuroimaging;Pediatric;traumatic brain injury (TBI)
Study Design
Cross Sectional Study
Study Approach
Country of Study
Publication Country
United States