Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters.

Journal: Translational psychiatry

Volume: 10

Issue: 1

Year of Publication: 2021

Affiliated Institutions:  Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, Netherlands. willembenjamin@gmail.com. Department of Physiology, Anatomy and Genetics, Oxford, UK. Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, Netherlands. Department of mathematics and applied mathematics, University of Cape Town, Cape Town, South Africa. Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain. The Margaret and Wallace McCain Centre for Child, Youth and Family Mental Health, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Canada. Department of Psychiatry, Yale University School of Medicine, New Haven, CT, , USA. Mathison Centre for Mental Health Research and Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy. Psychiatry and Clinical Psychobiology, Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milano, Italy. Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany. Amsterdam UMC, Vrije Universteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands. Obsessive-Compulsive Disorder (OCD) Clinic Department of Psychiatry National Institute of Mental Health and Neurosciences, Bangalore, India. Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland. McLean Hospital, Harvard Medical School, Belmont, MA, , USA. Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands. Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari, Barcelona, Spain. Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China. Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, , USA. Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, , USA. Department of Psychiatry, University of Michigan, Ann Arbor, MI, , USA. Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa. Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, München, Germany. Research Center for Child Mental Development, Chiba University, Chiba, Japan. Departamento e Instituto de Psiquiatria do Hospital das Clinicas, IPQ HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil. Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine, Shanghai, China. De Bascule, Academic Center for Child and Adolescent Psychiatry, Amsterdam, The Netherlands. Division of Child and Adolescent Psychiatry, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, , USA. Department of Psychiatry, , Oxford University, Oxford, UK. University of British Columbia, Vancouver, BC, VT Z, Canada. Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway. Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea. SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. Columbia University Irving Medical Center, Columbia University, New York, NY, , USA. Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden. Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, LS L, Canada. Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Division of Child and Adolescent Psychiatry, Jane and Terry Semel Institute For Neurosciences, University of California, Los Angeles, CA, , USA. Magnetic Resonance Image Core Facility, IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain. University of Zürich, University Hospital Zürich, Dept. Neuroradiology, Zürich, Switzerland. Center of Mathematics, Computing and Cognition, Universidade Federal do ABC, Santo Andre, Brazil. Orygen, Parkville, VIC, Australia. Pediatric OCD Consultation service, Anxiety Treatment and Research Center, St. Joseph's HealthCare, Hamilton, ON, LC E, Canada. Department of Psychiatry, New York University Langone School of Medicine, New York, NY, , USA. Olin Neuropsychiatry Research Center, Hartford Hospital, Hartford, CT, , USA. Icahn School of Medicine at Mount Sinai, New York, NY, , USA. Institute of Living/Hartford Hospital, Hartford, CT, , USA. Seoul National University Hospital, Seoul, Republic of Korea. Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognitive Neuroimaging, Radboud University Medical Centre, Nijmegen, The Netherlands. Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, , USA. SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, Netherlands. g.a.vanwingen@amsterdamumc.nl.

Abstract summary 

No diagnostic biomarkers are available for obsessive-compulsive disorder (OCD). Here, we aimed to identify magnetic resonance imaging (MRI) biomarkers for OCD, using 46 data sets with 2304 OCD patients and 2068 healthy controls from the ENIGMA consortium. We performed machine learning analysis of regional measures of cortical thickness, surface area and subcortical volume and tested classification performance using cross-validation. Classification performance for OCD vs. controls using the complete sample with different classifiers and cross-validation strategies was poor. When models were validated on data from other sites, model performance did not exceed chance-level. In contrast, fair classification performance was achieved when patients were grouped according to their medication status. These results indicate that medication use is associated with substantial differences in brain anatomy that are widely distributed, and indicate that clinical heterogeneity contributes to the poor performance of structural MRI as a disease marker.

Authors & Co-authors:  Bruin Willem B WB Taylor Luke L Thomas Rajat M RM Shock Jonathan P JP Zhutovsky Paul P Abe Yoshinari Y Alonso Pino P Ameis Stephanie H SH Anticevic Alan A Arnold Paul D PD Assogna Francesca F Benedetti Francesco F Beucke Jan C JC Boedhoe Premika S W PSW Bollettini Irene I Bose Anushree A Brem Silvia S Brennan Brian P BP Buitelaar Jan K JK Calvo Rosa R Cheng Yuqi Y Cho Kang Ik K KIK Dallaspezia Sara S Denys Damiaan D Ely Benjamin A BA Feusner Jamie D JD Fitzgerald Kate D KD Fouche Jean-Paul JP Fridgeirsson Egill A EA Gruner Patricia P Gürsel Deniz A DA Hauser Tobias U TU Hirano Yoshiyuki Y Hoexter Marcelo Q MQ Hu Hao H Huyser Chaim C Ivanov Iliyan I James Anthony A Jaspers-Fayer Fern F Kathmann Norbert N Kaufmann Christian C Koch Kathrin K Kuno Masaru M Kvale Gerd G Kwon Jun Soo JS Liu Yanni Y Lochner Christine C Lázaro Luisa L Marques Paulo P Marsh Rachel R Martínez-Zalacaín Ignacio I Mataix-Cols David D Menchón José M JM Minuzzi Luciano L Moreira Pedro S PS Morer Astrid A Morgado Pedro P Nakagawa Akiko A Nakamae Takashi T Nakao Tomohiro T Narayanaswamy Janardhanan C JC Nurmi Erika L EL O'Neill Joseph J Pariente Jose C JC Perriello Chris C Piacentini John J Piras Fabrizio F Piras Federica F Reddy Y C Janardhan YCJ Rus-Oswald Oana G OG Sakai Yuki Y Sato João R JR Schmaal Lianne L Shimizu Eiji E Simpson H Blair HB Soreni Noam N Soriano-Mas Carles C Spalletta Gianfranco G Stern Emily R ER Stevens Michael C MC Stewart S Evelyn SE Szeszko Philip R PR Tolin David F DF Venkatasubramanian Ganesan G Wang Zhen Z Yun Je-Yeon JY van Rooij Daan D Thompson Paul M PM van den Heuvel Odile A OA Stein Dan J DJ van Wingen Guido A GA

Study Outcome 

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Citations :  Ruscio AM, et al. The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication. Psychiatry Res. 2010;15:513–517.
Authors :  92
Identifiers
Doi : 342
SSN : 2158-3188
Study Population
Male,Female
Mesh Terms
Biomarkers
Other Terms
Study Design
Cross Sectional Study
Study Approach
Country of Study
Publication Country
United States