Greater male than female variability in regional brain structure across the lifespan.

Journal: Human brain mapping

Volume: 43

Issue: 1

Year of Publication: 2022

Affiliated Institutions:  Institute of Psychology, Leiden University, Leiden, The Netherlands. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Department of Psychology, School of Arts and Social Sciences, City, University of London, London, UK. Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands. Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland. FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain. Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Department of Psychiatry, Yale University, New Haven, Connecticut, USA. Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany. Imaging Diagnostic Center, Hospital Clínic, Barcelona, Spain. Department for Clinical Psychology, Würzburg University, Margetshöchheim, Germany. Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy. Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands. Department of Psychiatry, University of Basel, Basel, Switzerland. Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA. Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia. Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands. Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands. Laboratory of Psychiatric Neuroimaging (LIM-), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech, Atlanta, Georgia, USA. MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. Department of Child and Adolescent Psychiatry, NYU Grossman School of Medicine, New York, New York, USA. Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. Psychology Clinical Neuroscience Center, Department of Psychology, University of New Mexico, Albuquerque, New Mexico, USA. CHU Sainte-Justine Research Center, Montreal, Quebec, Canada. Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Tübingen, Tübingen, Germany. Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, Bordeaux, France. Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia. Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada. Division of Psychological & Social Medicine and Developmental Neurosciences; Technische Universität Dresden, Faculty of Medicine, University Hospital C.G. Carus, Dresden, Germany. Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands. Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, Western Cape, South Africa. Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands. IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy. Tommy Fuss Center for Neuropsychiatric Disease Research, Department of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA. Department of Psychology, Stanford University, Stanford, California, USA. Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany. Department of Early Psychosis, Amsterdam UMC, Amsterdam, The Netherlands. Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, Australia. Interdisciplinary Center Psychopathology and Emotion regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia. Departments of Experimental and Clinical Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany. Neuroscience Institute, University of Cape Town, Cape Town, Western Cape, South Africa. De Bascule, Academic center child and adolescent psychiatry, Duivendrecht, The Netherlands. Department of Psychiatry, Warneford Hospital, Oxford, UK. Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, Western Cape, South Africa. Department of Radiology, The Ohio State University College of Medicine, Columbus, Ohio, USA. Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. Sunshine Coast Mind and Neuroscience Thompson Institute, Birtinya, Queensland, Australia. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain. Laboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow, Russia. Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA. SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Cape Town, Western Cape, South Africa. Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands. Institut des maladies neurodégénératives, Université de Bordeaux, Bordeaux, France. Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, Barcelona, Spain. Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden. University of Bordeaux, Bordeaux, France. Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA. Division of Psychiatry, University of Edinburgh, Edinburgh, UK. Herston Imaging Research Facility and School of Clinical Sciences, Queensland University of Technology (QUT), Brisbane, Queensland, Australia. Department of Radiation Sciences, Umeå University, Umeå, Sweden. Emma Children's Hospital, Amsterdam UMC University of Amsterdam and Vrije Universiteit Amsterdam, Emma Neuroscience Group, Department of Pediatrics, Amsterdam Reproduction & Development, Amsterdam, The Netherlands. Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Department of Psychology, University of Würzburg, Würzburg, Germany. Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfur am Maint, Germany. Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA. Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA. West Region, Institute of Mental Health, Singapore, Singapore. Department of Neuroimaging, Institute of Psychiatry, Psychology and Neurology, King's College London, London, UK. Department of Biomedical Sciences of Cells and Systems, Rijksuniversiteit Groningen, University Medical Center Groningen, Groningen, The Netherlands. SAMRC Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, Western Cape, South Africa. Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Department of Psychiatry & Amsterdam Neuroscience, Amsterdam UMC, location VUMC, Amsterdam, The Netherlands. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. Institute for Experimental Epileptology and Cognition Research, University Hospital Bonn, Bonn, Germany. Department of Neuroimaging, King's College London, London, UK. Department of Child and Adolescent Psychiatry, NYU Child Study Center, Hassenfeld Children's Hospital at NYU Langone, New York, New York, USA. Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany. Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.

Abstract summary 

For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.

Authors & Co-authors:  Wierenga Lara M LM Doucet Gaelle E GE Dima Danai D Agartz Ingrid I Aghajani Moji M Akudjedu Theophilus N TN Albajes-Eizagirre Anton A Alnaes Dag D Alpert Kathryn I KI Andreassen Ole A OA Anticevic Alan A Asherson Philip P Banaschewski Tobias T Bargallo Nuria N Baumeister Sarah S Baur-Streubel Ramona R Bertolino Alessandro A Bonvino Aurora A Boomsma Dorret I DI Borgwardt Stefan S Bourque Josiane J den Braber Anouk A Brandeis Daniel D Breier Alan A Brodaty Henry H Brouwer Rachel M RM Buitelaar Jan K JK Busatto Geraldo F GF Calhoun Vince D VD Canales-Rodríguez Erick J EJ Cannon Dara M DM Caseras Xavier X Castellanos Francisco X FX Chaim-Avancini Tiffany M TM Ching Christopher Rk CR Clark Vincent P VP Conrod Patricia J PJ Conzelmann Annette A Crivello Fabrice F Davey Christopher G CG Dickie Erin W EW Ehrlich Stefan S Van't Ent Dennis D Fisher Simon E SE Fouche Jean-Paul JP Franke Barbara B Fuentes-Claramonte Paola P de Geus Eco Jc EJ Di Giorgio Annabella A Glahn David C DC Gotlib Ian H IH Grabe Hans J HJ Gruber Oliver O Gruner Patricia P Gur Raquel E RE Gur Ruben C RC Gurholt Tiril P TP de Haan Lieuwe L Haatveit Beathe B Harrison Ben J BJ Hartman Catharina A CA Hatton Sean N SN Heslenfeld Dirk J DJ van den Heuvel Odile A OA Hickie Ian B IB Hoekstra Pieter J PJ Hohmann Sarah S Holmes Avram J AJ Hoogman Martine M Hosten Norbert N Howells Fleur M FM Hulshoff Pol Hilleke E HE Huyser Chaim C Jahanshad Neda N James Anthony C AC Jiang Jiyang J Jönsson Erik G EG Joska John A JA Kalnin Andrew J AJ Klein Marieke M Koenders Laura L Kolskår Knut K KK Krämer Bernd B Kuntsi Jonna J Lagopoulos Jim J Lazaro Luisa L Lebedeva Irina S IS Lee Phil H PH Lochner Christine C Machielsen Marise Wj MW Maingault Sophie S Martin Nicholas G NG Martínez-Zalacaín Ignacio I Mataix-Cols David D Mazoyer Bernard B McDonald Brenna C BC McDonald Colm C McIntosh Andrew M AM McMahon Katie L KL McPhilemy Genevieve G van der Meer Dennis D Menchón José M JM Naaijen Jilly J Nyberg Lars L Oosterlaan Jaap J Paloyelis Yannis Y Pauli Paul P Pergola Giulio G Pomarol-Clotet Edith E Portella Maria J MJ Radua Joaquim J Reif Andreas A Richard Geneviève G Roffman Joshua L JL Rosa Pedro Gp PG Sacchet Matthew D MD Sachdev Perminder S PS Salvador Raymond R Sarró Salvador S Satterthwaite Theodore D TD Saykin Andrew J AJ Serpa Mauricio H MH Sim Kang K Simmons Andrew A Smoller Jordan W JW Sommer Iris E IE Soriano-Mas Carles C Stein Dan J DJ Strike Lachlan T LT Szeszko Philip R PR Temmingh Henk S HS Thomopoulos Sophia I SI Tomyshev Alexander S AS Trollor Julian N JN Uhlmann Anne A Veer Ilya M IM Veltman Dick J DJ Voineskos Aristotle A Völzke Henry H Walter Henrik H Wang Lei L Wang Yang Y Weber Bernd B Wen Wei W West John D JD Westlye Lars T LT Whalley Heather C HC Williams Steven Cr SC Wittfeld Katharina K Wolf Daniel H DH Wright Margaret J MJ Yoncheva Yuliya N YN Zanetti Marcus V MV Ziegler Georg C GC de Zubicaray Greig I GI Thompson Paul M PM Crone Eveline A EA Frangou Sophia S Tamnes Christian K CK

Study Outcome 

Source Link: Visit source

Statistics
Citations :  Alnæs, D. , Kaufmann, T. , van der Meer, D. , Córdova‐Palomera, A. , Rokicki, J. , Moberget, T. , … Westlye, L. T. (2019). Brain heterogeneity in schizophrenia and its association with polygenic risk. JAMA Psychiatry, 76(7), 739.
Authors :  160
Identifiers
Doi : 10.1002/hbm.25204
SSN : 1097-0193
Study Population
Male,Males,Female
Mesh Terms
Female
Other Terms
Study Design
Cross Sectional Study
Study Approach
Country of Study
Publication Country
United States