Nanocarriers for treatment of dermatological diseases: Principle, perspective and practices.

Journal: European journal of pharmacology

Volume: 890

Issue: 

Year of Publication: 2021

Affiliated Institutions:  School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, , Punjab, India. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, , Punjab, India. Electronic address: singhsachin@gmail.com. Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India. School of Pharmacy, International Medical University, Bukit Jalil, , Kuala Lumpur, Malaysia. Department of Chemical Pathology, School of Pathology, Faculty of Health Sciences and National Health Laboratory Service, University of the Free State, Bloemfontein, South Africa. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, , Australia.

Abstract summary 

Skin diseases are the fourth leading non-fatal skin conditions that act as a burden and affect the world economy globally. This condition affects the quality of a patient's life and has a pronounced impact on both their physical and mental state. Treatment of these skin conditions with conventional approaches shows a lack of efficacy, long treatment duration, recurrence of conditions, systemic side effects, etc., due to improper drug delivery. However, these pitfalls can be overcome with the applications of nanomedicine-based approaches that provide efficient site-specific drug delivery at the target site. These nanomedicine-based strategies are evolved as potential treatment opportunities in the form of nanocarriers such as polymeric and lipidic nanocarriers, nanoemulsions along with emerging others viz. carbon nanotubes for dermatological treatment. The current review focuses on challenges faced by the existing conventional treatments along with the topical therapeutic perspective of nanocarriers in treating various skin diseases. A total of 213 articles have been reviewed and the application of different nanocarriers in treating various skin diseases has been explained in detail through case studies of previously published research works. The toxicity related aspects of nanocarriers are also discussed.

Authors & Co-authors:  Ramanunny Arya Kadukkattil AK Wadhwa Sheetu S Gulati Monica M Singh Sachin Kumar SK Kapoor Bhupinder B Dureja Harish H Chellappan Dinesh Kumar DK Anand Krishnan K Dua Kamal K Khursheed Rubiya R Awasthi Ankit A Kumar Rajan R Kaur Jaskiran J Corrie Leander L Pandey Narendra Kumar NK

Study Outcome 

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Statistics
Citations : 
Authors :  15
Identifiers
Doi : 10.1016/j.ejphar.2020.173691
SSN : 1879-0712
Study Population
Male,Female
Mesh Terms
Administration, Cutaneous
Other Terms
Conventional formulations;Nanocarriers;Skin diseases;Stratum corneum
Study Design
Case Study,Cross Sectional Study
Study Approach
Systemic Review
Country of Study
Publication Country
Netherlands