Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis.

Journal: Molecular psychiatry

Volume: 26

Issue: 8

Year of Publication: 2022

Affiliated Institutions:  Department of Psychiatry, University of Toledo, Toledo, OH, USA. xin.wang@utoledo.edu. Department of Neurosciences, University of Toledo, Toledo, OH, USA. Department of Mathematics and Statistics, University of Toledo, Toledo, OH, USA. Department of Psychiatry, University of Toledo, Toledo, OH, USA. Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, CA, USA. National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA. Brain Imaging and Analysis Center, Duke University, Durham, NC, USA. Clinical Neuroscience Division, National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT, USA. University of Sydney, Westmead, NSW, Australia. Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA. Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, USA. Center for Trauma Recovery, Department of Psychological Sciences, University of Missouri-St. Louis, St. Louis, MO, USA. School of Psychology, University of New South Wales, Sydney, NSW, Australia. Health Services Research Center, University of California, San Diego, La Jolla, CA, USA. Department of Clinical Psychology, University of Groningen, Groningen, The Netherlands. Minneapolis VA Health Care System, Minneapolis, MN, USA. Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA. Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA. Department of Surgery, Division of Trauma & Acute Care Surgery, Medical College of Wisconsin, Milwaukee, WI, USA. Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA. Department of Psychology, Marquette University, Milwaukee, WI, USA. Department of Psychiatry, Amsterdam University Medical Centers, Location Academic Medical Center, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The Netherlands. Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands. Department of Psychiatry and Behavioral Health, Penn State College of Medicine, Hershey, PA, USA. Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA. Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA. Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany. Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany. Program for Traumatic Stress, Tibor Rubin VA Medical Center, Long Beach, CA, USA. Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA. Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium. Department of Psychiatry, University of Cape Town, Cape Town, South Africa. Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA. Division of Women's Mental Health, McLean Hospital, Belmont, MA, USA. Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA. Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA. Brain Dynamics Centre, Westmead Institute of Medical Research, University of Sydney, Westmead, NSW, Australia. Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, USA. Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Institute of Psychology, Chinese Academy of Sciences, Beijing, China. Departments of Radiology, Psychiatry, and Biomedical Engineering, University of Iowa, Iowa City, IA, USA. Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. VISN Center of Excellence for Research on Returning War Veterans, Doris Miller VA Medical Center, Waco, TX, USA. Department of Psychology, Harvard University, Boston, MA, USA. Department of Psychiatry, Columbia University Medical Center, New York, NY, USA. Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA. Department of Psychology, University of Washington, Seattle, WA, USA. Department of Radiology, University of Washington, Seattle, WA, USA. Sioux Falls VA Health Care System, Sioux Falls, SD, USA. Center for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USA. Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA. SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands. Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA. Department of Psychiatry, Amsterdam University Medical Centers, Location VU University Medical Center, VU University, Amsterdam, The Netherlands. Child and Adolescent Psychiatry, Leiden University Medical Center, Leiden, The Netherlands. Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. Department of Psychiatry and Behavioral Science, Texas A&M University College of Medicine, College Station, TX, USA.

Abstract summary 

Studies of posttraumatic stress disorder (PTSD) report volume abnormalities in multiple regions of the cerebral cortex. However, findings for many regions, particularly regions outside commonly studied emotion-related prefrontal, insular, and limbic regions, are inconsistent and tentative. Also, few studies address the possibility that PTSD abnormalities may be confounded by comorbid depression. A mega-analysis investigating all cortical regions in a large sample of PTSD and control subjects can potentially provide new insight into these issues. Given this perspective, our group aggregated regional volumes data of 68 cortical regions across both hemispheres from 1379 PTSD patients to 2192 controls without PTSD after data were processed by 32 international laboratories using ENIGMA standardized procedures. We examined whether regional cortical volumes were different in PTSD vs. controls, were associated with posttraumatic stress symptom (PTSS) severity, or were affected by comorbid depression. Volumes of left and right lateral orbitofrontal gyri (LOFG), left superior temporal gyrus, and right insular, lingual and superior parietal gyri were significantly smaller, on average, in PTSD patients than controls (standardized coefficients = -0.111 to -0.068, FDR corrected P values < 0.039) and were significantly negatively correlated with PTSS severity. After adjusting for depression symptoms, the PTSD findings in left and right LOFG remained significant. These findings indicate that cortical volumes in PTSD patients are smaller in prefrontal regulatory regions, as well as in broader emotion and sensory processing cortical regions.

Authors & Co-authors:  Wang Xin X Xie Hong H Chen Tian T Cotton Andrew S AS Salminen Lauren E LE Logue Mark W MW Clarke-Rubright Emily K EK Wall John J Dennis Emily L EL O'Leary Brian M BM Abdallah Chadi G CG Andrew Elpiniki E Baugh Lee A LA Bomyea Jessica J Bruce Steven E SE Bryant Richard R Choi Kyle K Daniels Judith K JK Davenport Nicholas D ND Davidson Richard J RJ DeBellis Michael M deRoon-Cassini Terri T Disner Seth G SG Fani Negar N Fercho Kelene A KA Fitzgerald Jacklynn J Forster Gina L GL Frijling Jessie L JL Geuze Elbert E Gomaa Hassaan H Gordon Evan M EM Grupe Dan D Harpaz-Rotem Ilan I Haswell Courtney C CC Herzog Julia I JI Hofmann David D Hollifield Michael M Hosseini Bobak B Hudson Anna R AR Ipser Jonathan J Jahanshad Neda N Jovanovic Tanja T Kaufman Milissa L ML King Anthony P AP Koch Saskia B J SBJ Koerte Inga K IK Korgaonkar Mayuresh S MS Krystal John H JH Larson Christine C Lebois Lauren A M LAM Levy Ifat I Li Gen G Magnotta Vincent A VA Manthey Antje A May Geoffrey G McLaughlin Katie A KA Mueller Sven C SC Nawijn Laura L Nelson Steven M SM Neria Yuval Y Nitschke Jack B JB Olff Miranda M Olson Elizabeth A EA Peverill Matthew M Phan K Luan KL Rashid Faisal M FM Ressler Kerry K Rosso Isabelle M IM Sambrook Kelly K Schmahl Christian C Shenton Martha E ME Sierk Anika A Simons Jeffrey S JS Simons Raluca M RM Sponheim Scott R SR Stein Murray B MB Stein Dan J DJ Stevens Jennifer S JS Straube Thomas T Suarez-Jimenez Benjamin B Tamburrino Marijo M Thomopoulos Sophia I SI van der Wee Nic J A NJA van der Werff Steven J A SJA van Erp Theo G M TGM van Rooij Sanne J H SJH van Zuiden Mirjam M Varkevisser Tim T Veltman Dick J DJ Vermeiren Robert R J M RRJM Walter Henrik H Wang Li L Zhu Ye Y Zhu Xi X Thompson Paul M PM Morey Rajendra A RA Liberzon Israel I

Study Outcome 

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Statistics
Citations :  Kessler RC, Aguilar-Gaxiola S, Alonso J, Benjet C, Bromet EJ, Cardoso G, et al. Trauma and PTSD in the WHO World Mental Health Surveys. Eur J Psychotraumatol. 2017;8(sup5):1353383.
Authors :  97
Identifiers
Doi : 10.1038/s41380-020-00967-1
SSN : 1476-5578
Study Population
Male,Female
Mesh Terms
Cerebral Cortex
Other Terms
Study Design
Case Control Trial,Cross Sectional Study
Study Approach
Country of Study
Mali
Publication Country
England