Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation.
Journal: Molecular psychiatry
Volume: 26
Issue: 6
Year of Publication: 2021
Affiliated Institutions:
Erasmus MC, University Medical Center Rotterdam, Department of Adolescent and Child Psychiatry and Psychology, Rotterdam, The Netherlands.
University of Helsinki, Department of Psychology and Logopedics, Helsinki, Finland.
University of Cincinnati, College of Medicine, Department of Environmental Health, Cincinnati, OH, USA.
ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
University of Bristol, MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, UK.
Icahn School of Medicine at Mount Sinai, Department of Environmental Medicine and Public Health, New York, NY, USA.
Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Westat, Durham, NC, USA.
INSERM UMR-S , EPAR, Saint-Antoine Medical School, Paris, France.
Harvard Medical School, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
University of Cape Town, Department of Psychiatry and Mental Health, Cape Town, South Africa.
Beckman Research Institute of City of Hope, Department of Population Sciences, Duarte, CA, USA.
Columbia University, Department of Epidemiology, New York City, NY, USA.
Max-Planck-Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.
Columbia University Mailman School of Public Health, Precision Environmental Health Lab, New York, NY, USA.
University of California, Division of Environmental Health Sciences, School of Public Health, Berkeley, CA, USA.
Brigham and Women's Hospital, Channing Division of Network Medicine, Boston, MA, USA.
Erasmus MC, University Medical Center Rotterdam, Generation R Study Group, Rotterdam, The Netherlands.
Erasmus University Rotterdam, Department of Psychology, Education, and Child Studies, Rotterdam, The Netherlands.
Leiden University, Leiden Institute for Brain and Cognition, Leiden, The Netherlands.
Finnish Institute for Health and Welfare, Helsinki, Finland.
University of Southern Denmark, Institute of Clinical Research and Department of Gynaecology and Obstetrics, Odense, Denmark.
National Institute of Public Health, Center for Nutrition and Health Research, Cuernavaca, Mor, Mexico.
Bradford Institute for Health Research, Bradford Teaching Hospitals, NHS Foundation Trust, Bradford, UK.
Icahn School of Medicine at Mount Sinai, Environmental Medicine & Public Health, Institute for Exposomic Research, New York, NY, USA.
University of Cape Town, Department of Paediatrics and Child Health, Cape Town, South Africa.
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
Erasmus MC, University Medical Center Rotterdam, Department of Adolescent and Child Psychiatry and Psychology, Rotterdam, The Netherlands. tiemeier@hsph.harvard.edu.
Abstract summary
Maternal anxiety during pregnancy is associated with adverse foetal, neonatal, and child outcomes, but biological mechanisms remain unclear. Altered foetal DNA methylation (DNAm) has been proposed as a potential underlying mechanism. In the current study, we performed a meta-analysis to examine the associations between maternal anxiety, measured prospectively during pregnancy, and genome-wide DNAm from umbilical cord blood. Sixteen non-overlapping cohorts from 12 independent longitudinal studies of the Pregnancy And Childhood Epigenetics Consortium participated, resulting in a combined dataset of 7243 mother-child dyads. We examined prenatal anxiety in relation to genome-wide DNAm and differentially methylated regions. We observed no association between the general symptoms of anxiety during pregnancy or pregnancy-related anxiety, and DNAm at any of the CpG sites, after multiple-testing correction. Furthermore, we identify no differentially methylated regions associated with maternal anxiety. At the cohort-level, of the 21 associations observed in individual cohorts, none replicated consistently in the other cohorts. In conclusion, contrary to some previous studies proposing cord blood DNAm as a promising potential mechanism explaining the link between maternal anxiety during pregnancy and adverse outcomes in offspring, we found no consistent evidence for any robust associations between maternal anxiety and DNAm in cord blood. Larger studies and analysis of DNAm in other tissues may be needed to establish subtle or subgroup-specific associations between maternal anxiety and the foetal epigenome.
Authors & Co-authors:
Sammallahti Sara S
Cortes Hidalgo Andrea P AP
Tuominen Samuli S
Malmberg Anni A
Mulder Rosa H RH
Brunst Kelly J KJ
Alemany Silvia S
McBride Nancy S NS
Yousefi Paul P
Heiss Jonathan A JA
McRae Nia N
Page Christian M CM
Jin Jianping J
Pesce Giancarlo G
Caramaschi Doretta D
Rifas-Shiman Sheryl L SL
Koen Nastassja N
Adams Charleen D CD
Magnus Maria C MC
Baïz Nour N
Ratanatharathorn Andrew A
Czamara Darina D
Håberg Siri E SE
Colicino Elena E
Baccarelli Andrea A AA
Cardenas Andres A
DeMeo Dawn L DL
Lawlor Deborah A DA
Relton Caroline L CL
Felix Janine F JF
van IJzendoorn Marinus H MH
Bakermans-Kranenburg Marian J MJ
Kajantie Eero E
Räikkönen Katri K
Sunyer Jordi J
Sharp Gemma C GC
Houtepen Lotte C LC
Nohr Ellen A EA
Sørensen Thorkild I A TIA
Téllez-Rojo Martha M MM
Wright Robert O RO
Annesi-Maesano Isabella I
Wright John J
Hivert Marie-France MF
Wright Rosalind J RJ
Zar Heather J HJ
Stein Dan J DJ
London Stephanie J SJ
Cecil Charlotte A M CAM
Tiemeier Henning H
Lahti Jari J
Study Outcome
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