PharmVar GeneFocus: CYP2B6.

Journal: Clinical pharmacology and therapeutics

Volume: 110

Issue: 1

Year of Publication: 2021

Affiliated Institutions:  Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA. Centre for Addiction and Mental Health and Departments of Pharmacology & Toxicology, and Psychiatry, University of Toronto, Toronto, Canada. Department of Biomedical Data Science, Stanford University, Stanford, California, USA. Discipline of Pharmacology, Adelaide Medical School, University of Adelaide, Adelaide, Australia. Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. Division of Human Genetics, Department of Pathology & Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany. Genomic Medicine Center, Children's Mercy, Kansas City, Missouri, USA. Division of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Children's Mercy, Kansas City, Missouri, USA.

Abstract summary 

The Pharmacogene Variation Consortium (PharmVar) catalogs star (*) allele nomenclature for the polymorphic human CYP2B6 gene. Genetic variation within the CYP2B6 gene locus impacts the metabolism or bioactivation of clinically important drugs. Of particular importance are efficacy and safety concerns regarding: efavirenz, which is used for the treatment of HIV type-1 infection; methadone, a mainstay in the treatment of opioid use disorder and as an analgesic; ketamine, used as an antidepressant and analgesic; and bupropion, which is prescribed to treat depression and for smoking cessation. This GeneFocus provides a comprehensive overview and summary of CYP2B6 and describes how haplotype information catalogued by PharmVar is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC).

Authors & Co-authors:  Desta Zeruesenay Z El-Boraie Ahmed A Gong Li L Somogyi Andrew A AA Lauschke Volker M VM Dandara Collet C Klein Kathrin K Miller Neil A NA Klein Teri E TE Tyndale Rachel F RF Whirl-Carrillo Michelle M Gaedigk Andrea A

Study Outcome 

Source Link: Visit source

Statistics
Citations :  Remmer H, Schoene B & Fleischmann RA Induction of the unspecific microsomal hydroxylase in the human liver. Drug Metab Dispos 1, 224–30 (1973).
Authors :  12
Identifiers
Doi : 10.1002/cpt.2166
SSN : 1532-6535
Study Population
Male,Female
Mesh Terms
Alleles
Other Terms
Study Design
Cross Sectional Study
Study Approach
Country of Study
Publication Country
United States