Mapping cortical and subcortical asymmetries in substance dependence: Findings from the ENIGMA Addiction Working Group.

Journal: Addiction biology

Volume: 26

Issue: 5

Year of Publication: 2022

Affiliated Institutions:  Department of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont, USA. Department of Psychological Sciences, School of Health Sciences, Swinburne University, Melbourne, Australia. Departments of Psychology, University of Amsterdam, Amsterdam, Netherlands. Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. Department of Neuroscience and The Ernest J. Del Monte Institute for Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA. Department of Psychiatry, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, Netherlands. Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia. Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado, USA. Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA. David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA. Neuroscience of Addiction and Mental Health Program, Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Sydney, Australia. Behavioural Science Institute, Radboud University, Nijmegen, Netherlands. Department of Psychiatry and Psychology, University of Barcelona, Barcelona, Spain. Clinical NeuroImaging Research Core, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA. VA San Diego Healthcare System and Department of Psychiatry, University of California San Diego, La Jolla, California, USA. Orygen, Parkville, Australia. Institute of Psychology and Leiden Institute for Brain and Cognition, Leiden University, Leiden, Netherlands. School of Psychology and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia. SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, USA. Department of Child and Adolescent Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany. Addiction Development and Psychopathology (ADAPT)-lab, Department of Psychology and Center for Urban Mental Health, University of Amsterdam, Amsterdam, Netherlands. BrainPark, Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging Facility, Monash University, Melbourne, Victoria, Australia. Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, California, USA. Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, Californis, USA. Department of Psychiatry, Université de Montreal, CHU Ste Justine Hospital, Montreal, Quebec, Canada.

Abstract summary 

Brain asymmetry reflects left-right hemispheric differentiation, which is a quantitative brain phenotype that develops with age and can vary with psychiatric diagnoses. Previous studies have shown that substance dependence is associated with altered brain structure and function. However, it is unknown whether structural brain asymmetries are different in individuals with substance dependence compared with nondependent participants. Here, a mega-analysis was performed using a collection of 22 structural brain MRI datasets from the ENIGMA Addiction Working Group. Structural asymmetries of cortical and subcortical regions were compared between individuals who were dependent on alcohol, nicotine, cocaine, methamphetamine, or cannabis (n = 1,796) and nondependent participants (n = 996). Substance-general and substance-specific effects on structural asymmetry were examined using separate models. We found that substance dependence was significantly associated with differences in volume asymmetry of the nucleus accumbens (NAcc; less rightward; Cohen's d = 0.15). This effect was driven by differences from controls in individuals with alcohol dependence (less rightward; Cohen's d = 0.10) and nicotine dependence (less rightward; Cohen's d = 0.11). These findings suggest that disrupted structural asymmetry in the NAcc may be a characteristic of substance dependence.

Authors & Co-authors:  Cao Zhipeng Z Ottino-Gonzalez Jonatan J Cupertino Renata B RB Schwab Nathan N Hoke Colin C Catherine Orr O Cousijn Janna J Dagher Alain A Foxe John J JJ Goudriaan Anna E AE Hester Robert R Hutchison Kent K Li Chiang-Shan R CR London Edythe D ED Lorenzetti Valentina V Luijten Maartje M Martin-Santos Rocio R Momenan Reza R Paulus Martin P MP Schmaal Lianne L Sinha Rajita R Sjoerds Zsuzsika Z Solowij Nadia N Stein Dan J DJ Stein Elliot A EA Uhlmann Anne A van Holst Ruth J RJ Veltman Dick J DJ Wiers Reinout W RW Yücel Murat M Zhang Sheng S Jahanshad Neda N Thompson Paul M PM Conrod Patricia P Mackey Scott S Garavan Hugh H

Study Outcome 

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Statistics
Citations :  Substance Abuse and Mental Health Services Administration (2019): Key substance use and mental health indicators in the United States: Results from the 2018 National Survey on Drug Use and Health. Retrieved from https://www.samhsa.gov/data.
Authors :  36
Identifiers
Doi : 10.1111/adb.13010
SSN : 1369-1600
Study Population
Male,Female
Mesh Terms
Adult
Other Terms
brain asymmetry;mega-analysis;substance dependence
Study Design
Cross Sectional Study
Study Approach
Quantitative
Country of Study
Publication Country
United States