Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years.
Journal: Human brain mapping
Volume: 43
Issue: 1
Year of Publication: 2022
Affiliated Institutions: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, New York, USA. Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom. Psychology and Human Development, Institute of Education, University College London, London, United Kingdom. Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, Nebraska, USA. Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Department of Psychiatry, Amsterdam University Medical Centre, Vrije Universiteit, Amsterdam, Netherlands. Institute of Medical Imaging and Visualisation, Department of Medical Science and Public Health, Faculty of Health and Social Sciences, Bournemouth University, Poole, United Kingdom. FIDMAG Germanes Hospitalàries, Barcelona, Spain. Radiologics, Inc, Saint Louis, Missouri, USA. Department of Integrative Medical Biology, Umeå University, Umeå, Sweden. Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA. Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom. Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Heidelberg, Germany. Imaging Diagnostic Centre, Hospital Clinic, Barcelona University Clinic, Barcelona, Spain. Department of Psychology, Biological Psychology, Clinical Psychology and Psychotherapy, University of Würzburg, Würzburg, Germany. Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy. Department of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands. Department of Psychiatry & Psychotherapy, University of Lübeck, Lübeck, Germany. Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA. Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Kensington, New South Wales, Australia. Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands. Donders Center of Medical Neurosciences, Radboud University, Nijmegen, Netherlands. Laboratory of Psychiatric Neuroimaging, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. Department of Psychology, Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA. Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, USA Neurology, Radiology, Psychiatry and Biomedical Engineering, Emory University, Atlanta, Georgia, USA. Clinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics and NCBES Galway Neuroscience Centre, National University of Ireland, Galway, Ireland. MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom. Department of Child and Adolescent Psychiatry, New York University, New York, New York, USA. Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden. Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA. Mind-Body Research Group, Department of Neuroscience, KU Leuven, Leuven, Belgium. Department of Psychology, University of New Mexico, Albuquerque, New Mexico, USA. Department of Psychiatry, Université de Montréal, Montreal, Canada. Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Tübingen, Tübingen, Germany. Mental Health Research Networking Center (CIBERSAM), Madrid, Spain. Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, UMR, Université de Bordeaux, Bordeaux, France. Erasmus School of Social and Behavioural Sciences, Erasmus University Rotterdam, Rotterdam, Netherlands. Center for Multimodal Imaging and Genetics, Department of Neuroscience, University of California-San Diego, San Diego, California, USA. Department of Psychiatry and Psychotherapy, University of Münster, Germany. Department of Psychiatry, University of Melbourne, Melbourne, Australia. Academisch Medisch Centrum, Universiteit van Amsterdam, Amsterdam, Netherlands. Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia. Kimel Family Translational Imaging Genetics Laboratory, Campbell Family Mental Health Research Institute, CAMH, Campbell, Canada. Biological Psychiatry Lab, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy. Division of Psychological and Social Medicine and Developmental Neurosciences, Technische Universität Dresden, Dresden, Germany. Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany. Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands. Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa. Department of Psychiatry and Psychotherapy, Otto von Guericke University Magdeburg, Magdeburg, Germany. Department of Psychiatry, Tommy Fuss Center for Neuropsychiatric Disease Research Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Department of Psychology, Stanford University, Stanford, California, USA. Department of Psychiatry and Psychotherapy, University Medicine Greifswald, University of Greifswald, Greifswald, Germany. Department for Psychiatry, Psychosomatics and Psychotherapy, Universitätsklinikum Frankfurt, Goethe Universitat, Frankfurt, Germany. Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany. Department of Psychiatry, Yale University, New Haven, Connecticut, USA. Melbourne Neuropsychiatry Center, University of Melbourne, Melbourne, Australia. Interdisciplinary Center Psychopathology and Emotion regulation, University Medical Center Groningen, University of Groningen, Groningen, Netherlands. Brain and Mind Centre, University of Sydney, Sydney, Australia. Departments of Experimental and Clinical Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands. Personalized Healthcare, Genentech, Inc., South San Francisco, California, USA. Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, Netherlands. Department of Psychology, Yale University, New Haven, Connecticut, USA. Norbert Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, University of Greifswald, Greifswald, Germany. De Bascule, Academic Centre for Children and Adolescent Psychiatry, Amsterdam, Netherlands. Department of Psychiatry, Oxford University, Oxford, United Kingdom. Center for Human Development, Departments of Cognitive Science, Psychiatry, and Radiology, University of California, San Diego, California, USA. Department of Radiology, Ohio State University College of Medicine, Columbus, Ohio, USA. Department of Neuroinformatics, Araya, Inc., Tokyo, Japan. Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia. Sunshine Coast Mind and Neuroscience, Thompson Institute, University of the Sunshine Coast, Queensland, Australia. Department of Psychiatry, Psychosomatics and Psychotherapy, Julius-Maximilians Universität Würzburg, Würzburg, Germany. SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa. Queensland Institute of Medical Research, Berghofer Medical Research Institute, Queensland, Australia. Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom. School of Clinical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia. Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Heidelberg, Germany. Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, Netherlands. Department of Clinical Medicine, Kyushu University, Fukuoka, Japan. CatoSenteret Rehabilitation Hospital, Son, Norway. Department of Clinical Neuropsychology, Amsterdam University Medical Centre, Vrije Universiteit Amsterdam, Amsterdam, Netherlands. Department of Psychiatry, University of California at Irvine, Irvine, California, USA. Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA. Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Boston, Massachusetts, USA. Department of Psychiatry, University Hospital "Marques de Valdecilla", Instituto de Investigación Valdecilla (IDIVAL), Santander, Spain. Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Australia. Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany. Department of General Psychiatry, Institute of Mental Health, Singapore, Singapore. Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. Department of Biomedical Sciences of Cells and Systems, Rijksuniversiteit Groningen, University Medical Center Groningen, Groningen, Netherlands. Queensland Brain Institute, University of Queensland, Queensland, Australia. College of Arts and Sciences, Georgia State University, Atlanta, Georgia, USA. Department of Psychiatry, Leiden University Medical Center, Leiden, Netherlands. Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands. Institute of Community Medicine, University Medicine, Greifswald, University of Greifswald, Greifswald, Germany. Department of Psychology, University of Bath, Bath, United Kingdom. Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Evanston, Illinois, USA. Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. Institute for Experimental Epileptology and Cognition Research, University of Bonn, Bonn, Germany. Department of Psychology, University of Oslo, Oslo, Norway. Developmental and Educational Psychology Unit, Institute of Psychology, Leiden University, Leiden, Netherlands. Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada. National High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida, USA. Department of Child and Adolescent Psychiatry, Child Study Center, NYU Langone Health, New York City, New York, USA. Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany.
Abstract summary
Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.Authors & Co-authors: Frangou Sophia S Modabbernia Amirhossein A Williams Steven C R SCR Papachristou Efstathios E Doucet Gaelle E GE Agartz Ingrid I Aghajani Moji M Akudjedu Theophilus N TN Albajes-Eizagirre Anton A Alnaes Dag D Alpert Kathryn I KI Andersson Micael M Andreasen Nancy C NC Andreassen Ole A OA Asherson Philip P Banaschewski Tobias T Bargallo Nuria N Baumeister Sarah S Baur-Streubel Ramona R Bertolino Alessandro A Bonvino Aurora A Boomsma Dorret I DI Borgwardt Stefan S Bourque Josiane J Brandeis Daniel D Breier Alan A Brodaty Henry H Brouwer Rachel M RM Buitelaar Jan K JK Busatto Geraldo F GF Buckner Randy L RL Calhoun Vincent V Canales-Rodríguez Erick J EJ Cannon Dara M DM Caseras Xavier X Castellanos Francisco X FX Cervenka Simon S Chaim-Avancini Tiffany M TM Ching Christopher R K CRK Chubar Victoria V Clark Vincent P VP Conrod Patricia P Conzelmann Annette A Crespo-Facorro Benedicto B Crivello Fabrice F Crone Eveline A EA Dale Anders M AM Dannlowski Udo U Davey Christopher C de Geus Eco J C EJC de Haan Lieuwe L de Zubicaray Greig I GI den Braber Anouk A Dickie Erin W EW Di Giorgio Annabella A Doan Nhat Trung NT Dørum Erlend S ES Ehrlich Stefan S Erk Susanne S Espeseth Thomas T Fatouros-Bergman Helena H Fisher Simon E SE Fouche Jean-Paul JP Franke Barbara B Frodl Thomas T Fuentes-Claramonte Paola P Glahn David C DC Gotlib Ian H IH Grabe Hans-Jörgen HJ Grimm Oliver O Groenewold Nynke A NA Grotegerd Dominik D Gruber Oliver O Gruner Patricia P Gur Rachel E RE Gur Ruben C RC Hahn Tim T Harrison Ben J BJ Hartman Catharine A CA Hatton Sean N SN Heinz Andreas A Heslenfeld Dirk J DJ Hibar Derrek P DP Hickie Ian B IB Ho Beng-Choon BC Hoekstra Pieter J PJ Hohmann Sarah S Holmes Avram J AJ Hoogman Martine M Hosten Norbert N Howells Fleur M FM Hulshoff Pol Hilleke E HE Huyser Chaim C Jahanshad Neda N James Anthony A Jernigan Terry L TL Jiang Jiyang J Jönsson Erik G EG Joska John A JA Kahn Rene R Kalnin Andrew A Kanai Ryota R Klein Marieke M Klyushnik Tatyana P TP Koenders Laura L Koops Sanne S Krämer Bernd B Kuntsi Jonna J Lagopoulos Jim J Lázaro Luisa L Lebedeva Irina I Lee Won Hee WH Lesch Klaus-Peter KP Lochner Christine C Machielsen Marise W J MWJ Maingault Sophie S Martin Nicholas G NG Martínez-Zalacaín Ignacio I Mataix-Cols David D Mazoyer Bernard B McDonald Colm C McDonald Brenna C BC McIntosh Andrew M AM McMahon Katie L KL McPhilemy Genevieve G Meinert Susanne S Menchón José M JM Medland Sarah E SE Meyer-Lindenberg Andreas A Naaijen Jilly J Najt Pablo P Nakao Tomohiro T Nordvik Jan E JE Nyberg Lars L Oosterlaan Jaap J de la Foz Víctor Ortiz-García VO Paloyelis Yannis Y Pauli Paul P Pergola Giulio G Pomarol-Clotet Edith E Portella Maria J MJ Potkin Steven G SG Radua Joaquim J Reif Andreas A Rinker Daniel A DA Roffman Joshua L JL Rosa Pedro G P PGP Sacchet Matthew D MD Sachdev Perminder S PS Salvador Raymond R Sánchez-Juan Pascual P Sarró Salvador S Satterthwaite Theodore D TD Saykin Andrew J AJ Serpa Mauricio H MH Schmaal Lianne L Schnell Knut K Schumann Gunter G Sim Kang K Smoller Jordan W JW Sommer Iris I Soriano-Mas Carles C Stein Dan J DJ Strike Lachlan T LT Swagerman Suzanne C SC Tamnes Christian K CK Temmingh Henk S HS Thomopoulos Sophia I SI Tomyshev Alexander S AS Tordesillas-Gutiérrez Diana D Trollor Julian N JN Turner Jessica A JA Uhlmann Anne A van den Heuvel Odile A OA van den Meer Dennis D van der Wee Nic J A NJA van Haren Neeltje E M NEM van 't Ent Dennis D van Erp Theo G M TGM Veer Ilya M IM Veltman Dick J DJ Voineskos Aristotle A Völzke Henry H Walter Henrik H Walton Esther E Wang Lei L Wang Yang Y Wassink Thomas H TH Weber Bernd B Wen Wei W West John D JD Westlye Lars T LT Whalley Heather H Wierenga Lara M LM Wittfeld Katharina K Wolf Daniel H DH Worker Amanda A Wright Margaret J MJ Yang Kun K Yoncheva Yulyia Y Zanetti Marcus V MV Ziegler Georg C GC Thompson Paul M PM Dima Danai D
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Citations : Abe, O. , Yamasue, H. , Aoki, S. , Suga, M. , Yamada, H. , Kasai, K. , … Ohtomo, K. (2008). Aging in the CNS: Comparison of gray/white matter volume and diffusion tensor data. Neurobiology of Aging, 29(1), 102–116. 10.1016/j.neurobiolaging.2006.09.003Authors : 205
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Doi : 10.1002/hbm.25364SSN : 1097-0193