Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals.
Journal: Molecular psychiatry
Volume: 26
Issue: 11
Year of Publication: 2022
Affiliated Institutions:
Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Vita-Salute San Raffaele University, Milan, Italy.
Unit for Psychosomatics / CL Outpatient Clinic for Adults, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona Bipolar Disorders and Depressive Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
Department of Psychiatry, University of Münster, Münster, Germany.
Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
Research Group in Psychiatry GIPSI, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia.
Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Neuroscience Research Australia, Randwick, NSW, Australia.
Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Laureate Institute for Brain Research, Tulsa, OK, USA.
Department of Neuroscience and Physiology, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden.
School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
UCLA Center for Neurobehavioral Genetics, Los Angeles, CA, USA.
Research Group, Instituto de Alta Tecnología Médica, Ayudas diagnósticas SURA, Medellín, Colombia.
West Region, Institute of Mental Health, Singapore, Singapore.
Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Department of Child and Adolescent Psychiatry and Psychology, Erasmus University, Rotterdam, The Netherlands.
University of British Columbia, Vancouver, BC, Canada.
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. tomas.hajek@dal.ca.
Abstract summary
Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41% of the association between BD and ventricular volume was mediated by BMI (Z = 2.73, p = 0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. Future prospective brain imaging studies should investigate whether obesity could be a modifiable risk factor for neuroprogression.
Authors & Co-authors:
McWhinney Sean R SR
Abé Christoph C
Alda Martin M
Benedetti Francesco F
Bøen Erlend E
Del Mar Bonnin Caterina C
Borgers Tiana T
Brosch Katharina K
Canales-Rodríguez Erick J EJ
Cannon Dara M DM
Dannlowski Udo U
Díaz-Zuluaga Ana M AM
Elvsåshagen Torbjørn T
Eyler Lisa T LT
Fullerton Janice M JM
Goikolea Jose M JM
Goltermann Janik J
Grotegerd Dominik D
Haarman Bartholomeus C M BCM
Hahn Tim T
Howells Fleur M FM
Ingvar Martin M
Kircher Tilo T J TTJ
Krug Axel A
Kuplicki Rayus T RT
Landén Mikael M
Lemke Hannah H
Liberg Benny B
Lopez-Jaramillo Carlos C
Malt Ulrik F UF
Martyn Fiona M FM
Mazza Elena E
McDonald Colm C
McPhilemy Genevieve G
Meier Sandra S
Meinert Susanne S
Meller Tina T
Melloni Elisa M T EMT
Mitchell Philip B PB
Nabulsi Leila L
Nenadic Igor I
Opel Nils N
Ophoff Roel A RA
Overs Bronwyn J BJ
Pfarr Julia-Katharina JK
Pineda-Zapata Julian A JA
Pomarol-Clotet Edith E
Raduà Joaquim J
Repple Jonathan J
Richter Maike M
Ringwald Kai G KG
Roberts Gloria G
Salvador Raymond R
Savitz Jonathan J
Schmitt Simon S
Schofield Peter R PR
Sim Kang K
Stein Dan J DJ
Stein Frederike F
Temmingh Henk S HS
Thiel Katharina K
van Haren Neeltje E M NEM
Gestel Holly Van HV
Vargas Cristian C
Vieta Eduard E
Vreeker Annabel A
Waltemate Lena L
Yatham Lakshmi N LN
Ching Christopher R K CRK
Andreassen Ole O
Thompson Paul M PM
Hajek Tomas T
Study Outcome
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