ENIGMA-Sleep: Challenges, opportunities, and the road map.
Journal: Journal of sleep research
Volume: 30
Issue: 6
Year of Publication: 2021
Affiliated Institutions:
Institute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran.
University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Inst of Clinical Medicine, University of Oslo, Oslo, Norway.
GIGA-Institute, Cyclotron Research Center/In Vivo Imaging, Sleep and Chronobiology Lab, University of Liège, Liège, Belgium.
Psychiatry & Clinical Psychobiology, Division of Neuroscience, IRCCS Scientific Institute Ospedale San Raffaele, Milano, Italy.
Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Centre for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Institute of Science and Technology for Brain-inspired intelligence, Fudan University, Shanghai, China.
Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.
Institute of Neuroscience and Medicine, Brain & Behaviour (INM-), Research Centre Jülich, Jülich, Germany.
Institute of Neuroscience and Medicine, Structural and functional organisation of the brain (INM-), Research Centre Jülich, Jülich, Germany.
Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Department of Statistics, University of Oxford, Oxford, UK.
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Department of Psychiatry and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Department of Neurology, Samsung Medical Center, SBRI (Samsung Biomedical Research Institute), Sungkyunkwan University School of Medicine, Seoul, Korea.
Univ Paris Saclay, NeuroSpin neuroimaging platform, Psychiatry Team, UNIACT Lab, CEA Saclay, Gif-Sur-Yvette Cedex, France.
Department of Psychiatry & Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Laboratory of Neuro Imaging at USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Clinical Affective Neuroimaging Laboratory, Otto von Guericke University, Magdeburg, Germany.
Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Queensland Brain Institute, The University of Queensland, Brisbane, Qld, Australia.
Department of Physical Medicine and Rehabilitation, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Healthy Brain Aging and Sleep Center, Department of Psychiatry, NYU Grossman School of Medicine, New York, NY, USA.
Mary Mackillop Institute for Health Research, Australian Catholic University, Melbourne, Vic., Australia.
Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, AMC, Amsterdam, The Netherlands.
Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.
Sleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.
Department of Paediatrics, University of Melbourne, Parkville, Vic., Australia.
Institute of Mental Health, Buangkok, Singapore.
Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway.
Department of Psychology, Stanford University, Stanford, CA, USA.
Institute for Community Medicine, Department SHIP/Clinical Epidemiological Research, University Medicine Greifswald, Greifswald, Germany.
Department of Sleep and Circadian Research, Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.
Department of Psychology and Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA.
Abstract summary
Neuroimaging and genetics studies have advanced our understanding of the neurobiology of sleep and its disorders. However, individual studies usually have limitations to identifying consistent and reproducible effects, including modest sample sizes, heterogeneous clinical characteristics and varied methodologies. These issues call for a large-scale multi-centre effort in sleep research, in order to increase the number of samples, and harmonize the methods of data collection, preprocessing and analysis using pre-registered well-established protocols. The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium provides a powerful collaborative framework for combining datasets across individual sites. Recently, we have launched the ENIGMA-Sleep working group with the collaboration of several institutes from 15 countries to perform large-scale worldwide neuroimaging and genetics studies for better understanding the neurobiology of impaired sleep quality in population-based healthy individuals, the neural consequences of sleep deprivation, pathophysiology of sleep disorders, as well as neural correlates of sleep disturbances across various neuropsychiatric disorders. In this introductory review, we describe the details of our currently available datasets and our ongoing projects in the ENIGMA-Sleep group, and discuss both the potential challenges and opportunities of a collaborative initiative in sleep medicine.
Authors & Co-authors:
Tahmasian Masoud M
Aleman André A
Andreassen Ole A OA
Arab Zahra Z
Baillet Marion M
Benedetti Francesco F
Bresser Tom T
Bright Joanna J
Chee Michael W L MWL
Chylinski Daphne D
Cheng Wei W
Deantoni Michele M
Dresler Martin M
Eickhoff Simon B SB
Eickhoff Claudia R CR
Elvsåshagen Torbjørn T
Feng Jianfeng J
Foster-Dingley Jessica C JC
Ganjgahi Habib H
Grabe Hans J HJ
Groenewold Nynke A NA
Ho Tiffany C TC
Bong Hong Seung S
Houenou Josselin J
Irungu Benson B
Jahanshad Neda N
Khazaie Habibolah H
Kim Hosung H
Koshmanova Ekaterina E
Kocevska Desi D
Kochunov Peter P
Lakbila-Kamal Oti O
Leerssen Jeanne J
Li Meng M
Luik Annemarie I AI
Muto Vincenzo V
Narbutas Justinas J
Nilsonne Gustav G
O'Callaghan Victoria S VS
Olsen Alexander A
Osorio Ricardo S RS
Poletti Sara S
Poudel Govinda G
Reesen Joyce E JE
Reneman Liesbeth L
Reyt Mathilde M
Riemann Dieter D
Rosenzweig Ivana I
Rostampour Masoumeh M
Saberi Amin A
Schiel Julian J
Schmidt Christina C
Schrantee Anouk A
Sciberras Emma E
Silk Tim J TJ
Sim Kang K
Smevik Hanne H
Soares Jair C JC
Spiegelhalder Kai K
Stein Dan J DJ
Talwar Puneet P
Tamm Sandra S
Teresi Giana L GL
Valk Sofie L SL
Van Someren Eus E
Vandewalle Gilles G
Van Egroo Maxime M
Völzke Henry H
Walter Martin M
Wassing Rick R
Weber Frederik D FD
Weihs Antoine A
Westlye Lars Tjelta LT
Wright Margaret J MJ
Wu Mon-Ju MJ
Zak Nathalia N
Zarei Mojtaba M
Study Outcome
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