Abstract summary 

Blood-cerebrospinal fluid (CSF) barrier transporters affect the influx and efflux of drugs. The antiretrovirals tenofovir and emtricitabine may be substrates of blood-brain barrier (BBB) and blood-CSF barrier transporters, but data are limited regarding the pharmacogenetics and pharmacokinetics of their central nervous system (CNS) penetration.We investigated genetic polymorphisms associated with CSF disposition of tenofovir and emtricitabine.We collected paired plasma and CSF samples from 47 HIV-positive black South African adults who were virologically suppressed on efavirenz, tenofovir and emtricitabine. We considered 1846 single-nucleotide polymorphisms from seven relevant transporter genes ( and ) and 782 met a linkage disequilibrium (LD)-pruning threshold.The geometric mean (95% confidence interval [CI]) values for tenofovir and emtricitabine CSF-to-plasma concentration ratios were 0.023 (0.021-0.026) and 0.528 (0.460-0.605), respectively. In linear regression models, the lowest -value for association with the tenofovir CSF-to-plasma ratio was rs1989830 ( = 1.2 × 10) and for emtricitabine, it was rs11921035 ( = 1.4 × 10). None withstood correction for multiple testing.No genetic polymorphisms were associated with plasma, CSF concentrations or CSF-to-plasma ratios for either tenofovir or emtricitabine.

Authors & Co-authors:  Decloedt Eric H EH Sinxadi Phumla Z PZ Wiesner Lubbe L Joska John A JA Haas David W DW Maartens Gary G

Study Outcome 

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