Prevalence and correlates of current suicide risk in an international sample of OCD adults: A report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) network and Obsessive Compulsive and Related Disorders Network (OCRN) of the European College of Neuropsychopharmacology.
Journal: Journal of psychiatric research
Volume: 140
Issue:
Year of Publication: 2021
Affiliated Institutions:
Luigi Sacco University Hospital, Psychiatry Unit, University of Milan, Milan, Italy; CRC 'Aldo Ravelli' for Neuro-technology and Experimental Brain Therapeutics, University of Milan, Milan, Italy.
Luigi Sacco University Hospital, Psychiatry Unit, University of Milan, Milan, Italy; CRC 'Aldo Ravelli' for Neuro-technology and Experimental Brain Therapeutics, University of Milan, Milan, Italy; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine and Montefiore Medical Center, New York, NY, USA.
School of Life and Medical Sciences, University of Hertfordshire and Hertfordshire Partnership University NHS Foundation Trust, Hatfield, Hertfordshire, United Kingdom.
SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Genomics of Psychiatric and Neurodegenerative Diseases Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City, Mexico; Carracci Medical Group, Mexico City, Mexico.
Carracci Medical Group, Mexico City, Mexico.
Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotechnologie, Università di Pisa, Italy.
Department of Psychiatry, University of Florence, Institute of Neurosciences, Florence, Italy.
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.
SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, University of Stellenbosch, South Africa.
Department of Psychiatry, Sisli Eftal Teaching and Research Hospital, Istanbul, Turkey.
University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry Sveti Naum, Sofia, Bulgaria.
Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Formerly National and Trustwide Services for OCD/BDD, SWLondon and St. George's, National Health Service Trust, London, United Kingdom.
Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Illinois, USA.
Turner Institute for Brain and Mental Health, Monash University, VIC, Australia; Obsessive, Compulsive, and Anxiety Spectrum Research Program, Institute of Psychiatry of the Federal University of Rio de Janeiro (UFRJ); and D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.
Psychiatry Unit at the Hospital Universitari de Bellvitge-IDIBELL, University of Barcelona, Cibersam, Barcelona, Spain.
Tel Aviv University, Sackler School of Medicine, Israel Post-Trauma Center, Research Foundation by the Sheba Medical Center, Israel.
Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy; Highly Specialised Service for OCD and BDD, Hertfordshire Partnership University NHS Foundation Trust and University of Hertfordshire, Hatfield, UK.
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA; Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. Electronic address: carolynrodriguez@stanford.edu.
Abstract summary
Obsessive-compulsive disorder (OCD), characterized by repetitive anxiety-inducing intrusive thoughts and compulsive behaviors, is associated with higher suicide ideation and suicide attempts than the general population. This study investigates the prevalence and the correlates of current suicide risk in adult outpatients in an international multisite cross-sectional sample of OCD outpatients.Data were derived from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) network's cross-sectional data set (N = 409). Current suicide risk (assessed by Item C of the MINI) and diagnoses of psychiatric disorders were based on DSM-IV. Chi-squared test for categorical variables and t-test for continuous variables were used to make statistical inferences about main features associated with current suicide risk. P < .05 was considered as statistically significant.The prevalence of current suicidal risk was 15.9%, with equal likelihood in sociodemographic variables, including age and gender. Increased rates of major depression and generalized anxiety disorder were associated to higher current suicide risk. Current suicide risk was also associated with higher severity of OCD, depressive comorbidity, and higher levels of disability. There were no significant differences in treatment correlates-including type of treatment and psychiatric hospitalizations-between the groups of individuals with and without current suicide risk.Our findings suggest that current suicide risk is common in patients with OCD and associated with various forms of pathology. Our work also provides further empirical data to support what is already known clinically: a worse clinical picture characterized by a high severity of OCD, high distress related to obsessions and compulsions, and the presence of comorbidities such as major depression and generalized anxiety disorder should be considered as relevant risk factors for suicide risk.
Authors & Co-authors:
Benatti Beatrice B
Dell'Osso Bernardo B
Shen Hanyang H
Filippou-Frye Maria M
Varias Andrea A
Sanchez Catherine C
Jo Booil B
Hollander Eric E
Fineberg Naomi A NA
Stein Dan J DJ
Nicolini Humberto H
Lanzagorta Nuria N
Marazziti Donatella D
Pallanti Stefano S
Van Ameringen Michael M
Lochner Christine C
Karamustafalioglu Oguz O
Hranov Luchezar L
Figee Martin M
Drummond Lynne L
Grant Jon E JE
Denys Damiaan D
Fontenelle Leonardo F LF
Menchon Jose M JM
Zohar Joseph J
Pellegrini Luca L
Rodriguez Carolyn I CI
Study Outcome
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