A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium.
Journal: Human brain mapping
Volume: 43
Issue: 1
Year of Publication: 2022
Affiliated Institutions:
Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois, USA.
Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California, USA.
Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Department of biomedical engineering, Oregon Health and Science university, Portland, Oregon, USA.
Department of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
NORMENT, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Department of Pediatrics, University of California Irvine, Irvine, California, USA.
Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota, USA.
Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California, USA.
Department of Psychiatry and Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.
Departments of Psychiatry & Neuroscience, University of New Mexico, Albuquerque, New Mexico, USA.
Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) [Georgia State University, Georgia Institute of Technology], Emory University, Atlanta, Georgia, USA.
Judith Ford Mental Health, VA San Francisco Healthcare System, San Francisco, California, USA.
Department of Psychology, University of Bath, Bath, UK.
Division of Psychological & Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU-Dresden, Dresden, Germany.
Mental Health Department, ASL Roma DSM, Rome, Italy.
Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
FIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM, Barcelona, Spain.
Centre for Addiction and Mental Health (CAMH), Toronto, Canada.
Department of Radiology, IDIVAL, Marqués de Valdecilla University Hospital, Santander, Spain.
University Hospital Virgen del Rocio, IBiS, University of Sevilla, CIBERSAM, Sevilla, Spain.
University Hospital Marqués de Valdecilla, IDIVAL, CIBERSAM, Santander, Spain.
Department of Psychiatry, University of Basel, Basel, Switzerland.
Centre for Neuroimaging and Cognitive Genomics, Discipline of Biochemistry, National University of Ireland Galway, Galway, Ireland.
Centre for Neuroimaging and Cognitive Genomics, School of Psychology, National University of Ireland Galway, Galway, Ireland.
Clinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics, National University of Ireland Galway, Galway, Ireland.
Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Dublin, Ireland.
Laboratory of Psychiatric Neuroimaging (LIM-), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Laboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow, Russia.
Department of Endogenous Mental Disorders, Mental Health Research Center, Moscow, Russia.
Department of Psychiatry, University of Oxford, Oxford, UK.
Centre for Psychiatry Reserach, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town, WC, South Africa.
School of Psychology, Faculty of Health, Queensland University of Technology (QUT), Brisbane, QLD, Australia.
School of Clinical Sciences, Queensland University of Technology (QUT), Brisbane, QLD, Australia.
Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.
Psychology & Neuroscience, Georgia State University, Atlanta, Georgia, USA.
Abstract summary
Schizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta-analysis, we employed the harmonized ENIGMA shape analysis protocols to collaboratively investigate subcortical brain structure shape differences between individuals with schizophrenia and healthy control participants. The study analyzed data from 2,833 individuals with schizophrenia and 3,929 healthy control participants contributed by 21 worldwide research groups participating in the ENIGMA Schizophrenia Working Group. Harmonized shape analysis protocols were applied to each site's data independently for bilateral hippocampus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained from T1-weighted structural MRI scans. Mass univariate meta-analyses revealed more-concave-than-convex shape differences in the hippocampus, amygdala, accumbens, and thalamus in individuals with schizophrenia compared with control participants, more-convex-than-concave shape differences in the putamen and pallidum, and both concave and convex shape differences in the caudate. Patterns of exaggerated asymmetry were observed across the hippocampus, amygdala, and thalamus in individuals with schizophrenia compared to control participants, while diminished asymmetry encompassed ventral striatum and ventral and dorsal thalamus. Our analyses also revealed that higher chlorpromazine dose equivalents and increased positive symptom levels were associated with patterns of contiguous convex shape differences across multiple subcortical structures. Findings from our shape meta-analysis suggest that common neurobiological mechanisms may contribute to gray matter reduction across multiple subcortical regions, thus enhancing our understanding of the nature of network disorganization in schizophrenia.
Authors & Co-authors:
Gutman Boris A BA
van Erp Theo G M TGM
Alpert Kathryn K
Ching Christopher R K CRK
Isaev Dmitry D
Ragothaman Anjani A
Jahanshad Neda N
Saremi Arvin A
Zavaliangos-Petropulu Artemis A
Glahn David C DC
Shen Li L
Cong Shan S
Alnaes Dag D
Andreassen Ole Andreas OA
Doan Nhat Trung NT
Westlye Lars T LT
Kochunov Peter P
Satterthwaite Theodore D TD
Wolf Daniel H DH
Huang Alexander J AJ
Kessler Charles C
Weideman Andrea A
Nguyen Dana D
Mueller Bryon A BA
Faziola Lawrence L
Potkin Steven G SG
Preda Adrian A
Mathalon Daniel H DH
Bustillo Juan J
Calhoun Vince V
Ford Judith M JM
Walton Esther E
Ehrlich Stefan S
Ducci Giuseppe G
Banaj Nerisa N
Piras Fabrizio F
Piras Federica F
Spalletta Gianfranco G
Canales-Rodríguez Erick J EJ
Fuentes-Claramonte Paola P
Pomarol-Clotet Edith E
Radua Joaquim J
Salvador Raymond R
Sarró Salvador S
Dickie Erin W EW
Voineskos Aristotle A
Tordesillas-Gutiérrez Diana D
Crespo-Facorro Benedicto B
Setién-Suero Esther E
van Son Jacqueline Mayoral JM
Borgwardt Stefan S
Schönborn-Harrisberger Fabienne F
Morris Derek D
Donohoe Gary G
Holleran Laurena L
Cannon Dara D
McDonald Colm C
Corvin Aiden A
Gill Michael M
Filho Geraldo Busatto GB
Rosa Pedro G P PGP
Serpa Mauricio H MH
Zanetti Marcus V MV
Lebedeva Irina I
Kaleda Vasily V
Tomyshev Alexander A
Crow Tim T
James Anthony A
Cervenka Simon S
Sellgren Carl M CM
Fatouros-Bergman Helena H
Agartz Ingrid I
Howells Fleur F
Stein Dan J DJ
Temmingh Henk H
Uhlmann Anne A
de Zubicaray Greig I GI
McMahon Katie L KL
Wright Margie M
Cobia Derin D
Csernansky John G JG
Thompson Paul M PM
Turner Jessica A JA
Wang Lei L
Study Outcome
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