Abstract summary 

To evaluate the associations of depressive symptoms and antidepressant use during pregnancy with the risks of preterm birth, low birth weight, small for gestational age (SGA), and low Apgar scores.MEDLINE, EMBASE, ClinicalTrials.gov, and PsycINFO up to June 2016.Data were sought from studies examining associations of depression, depressive symptoms, or use of antidepressants during pregnancy with gestational age, birth weight, SGA, or Apgar scores. Authors shared the raw data of their studies for incorporation into this individual participant data meta-analysis.We performed one-stage random-effects meta-analyses to estimate odds ratios (ORs) with 95% CIs. The 215 eligible articles resulted in 402,375 women derived from 27 study databases. Increased risks were observed for preterm birth among women with a clinical diagnosis of depression during pregnancy irrespective of antidepressant use (OR 1.6, 95% CI 1.2-2.1) and among women with depression who did not use antidepressants (OR 2.2, 95% CI 1.7-3.0), as well as for low Apgar scores in the former (OR 1.5, 95% CI 1.3-1.7), but not the latter group. Selective serotonin reuptake inhibitor (SSRI) use was associated with preterm birth among women who used antidepressants with or without restriction to women with depressive symptoms or a diagnosis of depression (OR 1.6, 95% CI 1.0-2.5 and OR 1.9, 95% CI 1.2-2.8, respectively), as well as with low Apgar scores among women in the latter group (OR 1.7, 95% CI 1.1-2.8).Depressive symptoms or a clinical diagnosis of depression during pregnancy are associated with preterm birth and low Apgar scores, even without exposure to antidepressants. However, SSRIs may be independently associated with preterm birth and low Apgar scores.PROSPERO, CRD42016035711.

Authors & Co-authors:  Vlenterie Richelle R van Gelder Marleen M H J MMHJ Anderson H Ross HR Andersson Liselott L Broekman Birit F P BFP Dubnov-Raz Gal G El Marroun Hanan H Ferreira Ema E Fransson Emma E van der Heijden Frank M M A FMMA Holzman Claudia B CB Kim J Jo JJ Khashan Ali S AS Kirkwood Betty R BR Kuijpers Harold J H HJH Lahti-Pulkkinen Marius M Mason Dan D Misra Dawn D Niemi Maria M Nordeng Hedvig M E HME Peacock Janet L JL Pickett Kate E KE Prady Stephanie L SL Premji Shahirose S SS Räikkönen Katri K Rubertsson Christine C Sahingoz Mine M Shaikh Kiran K Silver Richard K RK Slaughter-Acey Jaime J Soremekun Seyi S Stein Dan J DJ Sundström-Poromaa Inger I Sutter-Dallay Anne-Laure AL Tiemeier Henning H Uguz Faruk F Varela Pinelopi P Vrijkotte Tanja G M TGM Winterfeld Ursula U Zar Heather J HJ Zervas Iannis M IM Prins Judith B JB Pop-Purceleanu Monica M Roeleveld Nel N

Study Outcome 

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