Which outcomes are most important to measure in patients with COVID-19 and how and when should these be measured? Development of an international standard set of outcomes measures for clinical use in patients with COVID-19: a report of the International Consortium for Health Outcomes Measurement (ICHOM) COVID-19 Working Group.

Journal: BMJ open

Volume: 11

Issue: 11

Year of Publication: 2021

Affiliated Institutions:  International Consortium for Health Outcomes Measurement, Boston, Massachusetts, USA w.seligman@ichom.org. International Consortium for Health Outcomes Measurement, Boston, Massachusetts, USA. The Aga Khan University Hospital, Karachi, Pakistan. NIHR, London, UK. AZ Delta Campus Brugsesteenweg, Roeselare, West-Vlaanderen, Belgium. Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Hospital Moinhos de Vento, Porto Alegre, Brazil. King's Health Partners, London, London, UK. University of Michigan, Ann Arbor, Michigan, USA. The University of Sheffield, Sheffield, UK. Value for Health CoLAB, Lisboa, Portugal. Hospital do Coracao, Sao Paulo, Brazil. Universidad Complutense de Madrid, Madrid, Spain. Clinica del Country, Bogota, Colombia. NHS Wales, Cardiff, UK. The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA. University of Exeter, Exeter, UK. Mediclinic Southern Africa, Stellenbosch, South Africa. Duke University School of Medicine, Durham, North Carolina, USA. Providence Health Care, Seattle, Washington, USA. University of Calgary, Calgary, Alberta, Canada. Sheba Medical Center, Tel Hashomer, Israel. OLVG, Amsterdam, The Netherlands.

Abstract summary 

The COVID-19 pandemic has resulted in widespread morbidity and mortality with the consequences expected to be felt for many years. Significant variation exists in the care even of similar patients with COVID-19, including treatment practices within and between institutions. Outcome measures vary among clinical trials on the same therapies. Understanding which therapies are of most value is not possible unless consensus can be reached on which outcomes are most important to measure. Furthermore, consensus on the most important outcomes may enable patients to monitor and track their care, and may help providers to improve the care they offer through quality improvement. To develop a standardised minimum set of outcomes for clinical care, the International Consortium for Health Outcomes Measurement (ICHOM) assembled a working group (WG) of 28 volunteers, including health professionals, patients and patient representatives.A list of outcomes important to patients and professionals was generated from a systematic review of the published literature using the MEDLINE database, from review of outcomes being measured in ongoing clinical trials, from a survey distributed to patients and patient networks, and from previously published ICHOM standard sets in other disease areas. Using an online-modified Delphi process, the WG selected outcomes of greatest importance.The outcomes considered by the WG to be most important were selected and categorised into five domains: (1) functional status and quality of life, (2) mental functioning, (3) social functioning, (4) clinical outcomes and (5) symptoms. The WG identified demographic and clinical variables for use as case-mix risk adjusters. These included baseline demographics, clinical factors and treatment-related factors.Implementation of these consensus recommendations could help institutions to monitor, compare and improve the quality and delivery of care to patients with COVID-19. Their consistent definition and collection could also broaden the implementation of more patient-centric clinical outcomes research.

Authors & Co-authors:  Seligman William H WH Fialho Luz L Sillett Nick N Nielsen Christina C Baloch Farhala M FM Collis Philip P Demedts Ingel K M IKM Fleck Marcelo P MP Floriani Maiara A MA Gabriel Lucinda E K LEK Gagnier Joel J JJ Keetharuth Anju A Londral Ana A Ludwig Ingvar I L IIL Lumbreras Carlos C Moscoso Daza Alejandro A Muhammad Nasreen N Nader Bastos Gisele A GA Owen Christine W CW Powers John H JH Russell Anne-Marie AM Smith Michaela K MK Wang Tracy Y-P TY Wong Evan K EK Woodhouse Douglas C DC Zimlichman Eyal E Brinkman Kees K

Study Outcome 

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Statistics
Citations :  World Health Organization . WHO coronavirus disease (COVID-19) dashboard. Available: https://covid19.who.int/
Authors :  27
Identifiers
Doi : e051065
SSN : 2044-6055
Study Population
Male,Female
Mesh Terms
COVID-19
Other Terms
COVID-19;international health services;quality in healthcare
Study Design
Cross Sectional Study
Study Approach
Systemic Review
Country of Study
Publication Country
England