Abstract summary 

Rates of obesity have reached epidemic proportions, especially among people with psychiatric disorders. While the effects of obesity on the brain are of major interest in medicine, they remain markedly under-researched in psychiatry.We obtained body mass index (BMI) and magnetic resonance imaging-derived regional cortical thickness, surface area from 836 bipolar disorders (BD) and 1600 control individuals from 14 sites within the ENIGMA-BD Working Group. We identified regionally specific profiles of cortical thickness using K-means clustering and studied clinical characteristics associated with individual cortical profiles.We detected two clusters based on similarities among participants in cortical thickness. The lower thickness cluster (46.8% of the sample) showed thinner cortex, especially in the frontal and temporal lobes and was associated with diagnosis of BD, higher BMI, and older age. BD individuals in the low thickness cluster were more likely to have the diagnosis of bipolar disorder I and less likely to be treated with lithium. In contrast, clustering based on similarities in the cortical surface area was unrelated to BD or BMI and only tracked age and sex.We provide evidence that both BD and obesity are associated with similar alterations in cortical thickness, but not surface area. The fact that obesity increased the chance of having low cortical thickness could explain differences in cortical measures among people with BD. The thinner cortex in individuals with higher BMI, which was additive and similar to the BD-associated alterations, may suggest that treating obesity could lower the extent of cortical thinning in BD.

Authors & Co-authors:  McWhinney Sean R SR Abé Christoph C Alda Martin M Benedetti Francesco F Bøen Erlend E Del Mar Bonnin Caterina C Borgers Tiana T Brosch Katharina K Canales-Rodríguez Erick J EJ Cannon Dara M DM Dannlowski Udo U Diaz-Zuluaga Ana M AM Dietze Lorielle L Elvsåshagen Torbjørn T Eyler Lisa T LT Fullerton Janice M JM Goikolea Jose M JM Goltermann Janik J Grotegerd Dominik D Haarman Bartholomeus C M BCM Hahn Tim T Howells Fleur M FM Ingvar Martin M Kircher Tilo T J TTJ Krug Axel A Kuplicki Rayus T RT Landén Mikael M Lemke Hannah H Liberg Benny B Lopez-Jaramillo Carlos C Malt Ulrik F UF Martyn Fiona M FM Mazza Elena E McDonald Colm C McPhilemy Genevieve G Meier Sandra S Meinert Susanne S Meller Tina T Melloni Elisa M T EMT Mitchell Philip B PB Nabulsi Leila L Nenadic Igor I Opel Nils N Ophoff Roel A RA Overs Bronwyn J BJ Pfarr Julia-Katharina JK Pineda-Zapata Julian A JA Pomarol-Clotet Edith E Raduà Joaquim J Repple Jonathan J Richter Maike M Ringwald Kai G KG Roberts Gloria G Ross Alex A Salvador Raymond R Savitz Jonathan J Schmitt Simon S Schofield Peter R PR Sim Kang K Stein Dan J DJ Stein Frederike F Temmingh Henk S HS Thiel Katharina K Thomopoulos Sophia I SI van Haren Neeltje E M NEM Van Gestel Holly H Vargas Cristian C Vieta Eduard E Vreeker Annabel A Waltemate Lena L Yatham Lakshmi N LN Ching Christopher R K CRK Andreassen Ole A OA Thompson Paul M PM Hajek Tomas T

Study Outcome 

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