Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study.
Journal: Movement disorders : official journal of the Movement Disorder Society
Volume: 37
Issue: 4
Year of Publication: 2022
Affiliated Institutions: UVSQ, Univ. Paris-Sud, Inserm, Team "Exposome, Heredity, Cancer and Health," CESP, Université Paris-Saclay, Villejuif, France. Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tubingen, Tubingen, Germany. Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany. Translational Neuroscience, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-Belval, Luxembourg. Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany. Molecular Genetics Section, Laboratory of Neurogenetics, NIA, NIH, Bethesda, Maryland, USA. Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland, Australia. Department of Neurology, Medical University of Vienna, Wien, Austria. Department of Neurology, Wilhelminenspital, Wien, Austria. Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada. Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Murdoch, Australia. Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia. Department of Neurologie, Sorbonne Université, Institut du Cerveau-Paris Brain Institute-ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France. University Lille, Inserm, CHU Lille, UMR-S -LilNCog-Centre de Recherche Lille Neurosciences & Cognition, Lille, France. Department of Neurology, Ludwig Maximilians University of Munich, München, Germany. Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece. First Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece. Department of Molecular Medicine, University of Pavia, Pavia, Italy. UOC Medical Genetics and Advanced Cell Diagnostics, S. Andrea University Hospital, Rome, Italy. Department of Biomedical Sciences, Humanitas University, Milan, Italy. Parkinson Institute, Azienda Socio Sanitaria Territoriale (ASST) Gaetano Pini/CTO, Milan, Italy. Parkinson Institute, Fontazione Grigioni, Milan, Italy. Department of Neurology, San Gerardo Hospital, Monza, Italy. Institute for Biomedical Research and Innovation, National Research Council, Cosenza, Italy. Institute of Neurology, Magna Graecia University, Catanzaro, Italy. Institute of Molecular Bioimaging and Physiology National Research Council, Catanzaro, Italy. Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan. Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan. Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea. Neurology, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg. Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Department of Neurology, Nijmegen, The Netherlands. Department of Neurology, St Olav's Hospital and Norwegian University of Science and Technology, Trondheim, Norway. Department of Neurology, Oslo University Hospital, Oslo, Norway. Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal. Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa. Division of Neurology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa. Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain. Lab of Parkinson Disease and Other Neurodegenerative Movement Disorders, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain. Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Barcelona, Spain. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. Department of Clinical Sciences Lund, Neurology, Lund University, Skåne University Hospital, Lund, Sweden. University of Birmingham and Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom. Faculty of Medicine, Health and Life Sciences, Queens University, Belfast, United Kingdom. Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom. Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
Abstract summary
Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding.The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR).We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry).Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12-2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37-4.56], P = 0.003; P-difference with women = 0.029).Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society.Authors & Co-authors: Domenighetti Cloé C Sugier Pierre-Emmanuel PE Ashok Kumar Sreelatha Ashwin A Schulte Claudia C Grover Sandeep S Mohamed Océane O Portugal Berta B May Patrick P Bobbili Dheeraj R DR Radivojkov-Blagojevic Milena M Lichtner Peter P Singleton Andrew B AB Hernandez Dena G DG Edsall Connor C Mellick George D GD Zimprich Alexander A Pirker Walter W Rogaeva Ekaterina E Lang Anthony E AE Koks Sulev S Taba Pille P Lesage Suzanne S Brice Alexis A Corvol Jean-Christophe JC Chartier-Harlin Marie-Christine MC Mutez Eugénie E Brockmann Kathrin K Deutschländer Angela B AB Hadjigeorgiou Georges M GM Dardiotis Efthimos E Stefanis Leonidas L Simitsi Athina Maria AM Valente Enza Maria EM Petrucci Simona S Duga Stefano S Straniero Letizia L Zecchinelli Anna A Pezzoli Gianni G Brighina Laura L Ferrarese Carlo C Annesi Grazia G Quattrone Andrea A Gagliardi Monica M Matsuo Hirotaka H Kawamura Yusuke Y Hattori Nobutaka N Nishioka Kenya K Chung Sun Ju SJ Kim Yun Joong YJ Kolber Pierre P van de Warrenburg Bart P C BPC Bloem Bastiaan R BR Aasly Jan J Toft Mathias M Pihlstrøm Lasse L Correia Guedes Leonor L Ferreira Joaquim J JJ Bardien Soraya S Carr Jonathan J Tolosa Eduardo E Ezquerra Mario M Pastor Pau P Diez-Fairen Monica M Wirdefeldt Karin K Pedersen Nancy L NL Ran Caroline C Belin Andrea C AC Puschmann Andreas A Hellberg Clara C Clarke Carl E CE Morrison Karen E KE Tan Manuela M Krainc Dimitri D Burbulla Lena F LF Farrer Matt J MJ Krüger Rejko R Gasser Thomas T Sharma Manu M Elbaz Alexis A
Study Outcome
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Citations : Jiang W, Ju C, Jiang H, Zhang D. Dairy foods intake and risk of Parkinson's disease: a dose-response meta-analysis of prospective cohort studies. Eur J Epidemiol 2014;29:613-619.Authors : 80
Identifiers
Doi : 10.1002/mds.28902SSN : 1531-8257