The thalamus and its subnuclei-a gateway to obsessive-compulsive disorder.
Journal: Translational psychiatry
Volume: 12
Issue: 1
Year of Publication: 2022
Affiliated Institutions: Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences, Amsterdam, The Netherlands. c.j.weeland@amsterdamumc.nl. Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences, Amsterdam, The Netherlands. Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. Bellvitge Biomedical Research Insitute-IDIBELL, Bellvitge University Hospital, Barcelona, Spain. Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada. Departments of Psychiatry and Neuroscience, Yale University, New Haven, CT, USA. The Mathison Centre for Mental Health Research & Education, Departments of Psychiatry and Medical Genetics, Calgary, Canada. OCD clinic, Department of Psychiatry, National Institute of Mental Health And Neurosciences (NIMHANS), Bangalore, India. Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy. Magnetic Resonance Image Core Facility, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. Departamento de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. Vita-Salute San Raffaele University, Milano, Italy. Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany. Psychiatry and Clinical Psychobiology, Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milano, Italy. Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway. Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland. Icahn School of Medicine at Mount Sinai Department of Psychiatry, New York, NY, USA. Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China. Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Obsessive-Compulsive Spectrum Disorders Program, Departamento e Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil. IRCCS Ospedale San Raffaele, Milano Italy Psychiatry, Milano, Italy. Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands. Department of Psychiatry, New York University School of Medicine, New York, NY, USA. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada. Columbia University Medical College, Columbia University, New York, NY, USA. Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa. Department of Psychiatry, Yale University, New Haven, CT, USA. Research Center for Child Mental Development, Chiba University, Chiba, Japan. Levvel, Academic Center for Child and Adolescent Psychiatry, Amsterdam, the Netherlands. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Psychiatry, University of British Columbia, Vancouver, Canada. Seoul National University Hospital, Department of Neuropsychiatry, Seoul, Republic of Korea. Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität, München, Germany. Department of Brain and Cognitive Sciences, Seoul National University College of Natural Science, Seoul, Republic of Korea. Department of Child and Adolescent Psychiatry and Psychology, Hospital Clinic, IDIBAPS, Barcelona, Spain. CIBERSAM, Barcelona, Spain. Stellenbosch University, SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch, South Africa. Department of Clinical Neuroscience, Centre for Psychiatric Research and Education, Karolinska Institutet, Stockholm, Sweden. Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada. Graduate School of Medical Science Kyoto Prefectural University of Medicine, Department of Psychiatry, Kyoto, Japan. Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA. Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic, Barcelona, Spain. UCLA Semel Institute, Division of Child and Adolescent Psychiatry, Los Angeles, CA, USA. Department of Psychiatry and Yale Child Study Center, Yale University, New Haven, CT, USA. TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München, München, Germany. Department of Integrative Medicine, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India. Columbia University Irving Medical College, Columbia University, New York, NY, USA. IRCCS Santa Lucia Foundation, Laboratory of Neuropsychiatry, Rome, Italy. Institute of Living, Hartford, CT, USA. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Department of Child Psychiatry, Chiba University Hospital, Chiba, Japan. Department of Psychiatry, Sir Run-Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. Yale University School of Medicine, New Haven, CT, USA. National Institute of Mental Health And Neurosciences, Department of Psychiatry, Bengaluru, India. Amsterdam UMC, Department of Child and Adolescent Psychiatry, Amsterdam, the Netherlands. Seoul National University Hospital, Seoul, Republic of Korea. Erasmus Medical Center, Department of Child and Adolescent Psychiatry/Psychology, Wytemaweg , GD, Rotterdam, the Netherlands. Imaging Genetics Center, Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Abstract summary
Larger thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population. Particular thalamic subregions may drive these differences. The ENIGMA-OCD working group conducted mega- and meta-analyses to study thalamic subregional volume in OCD across the lifespan. Structural T-weighted brain magnetic resonance imaging (MRI) scans from 2649 OCD patients and 2774 healthy controls across 29 sites (50 datasets) were processed using the FreeSurfer built-in ThalamicNuclei pipeline to extract five thalamic subregions. Volume measures were harmonized for site effects using ComBat before running separate multiple linear regression models for children, adolescents, and adults to estimate volumetric group differences. All analyses were pre-registered ( https://osf.io/73dvy ) and adjusted for age, sex and intracranial volume. Unmedicated pediatric OCD patients (<12 years) had larger lateral (d = 0.46), pulvinar (d = 0.33), ventral (d = 0.35) and whole thalamus (d = 0.40) volumes at unadjusted p-values <0.05. Adolescent patients showed no volumetric differences. Adult OCD patients compared with controls had smaller volumes across all subregions (anterior, lateral, pulvinar, medial, and ventral) and smaller whole thalamic volume (d = -0.15 to -0.07) after multiple comparisons correction, mostly driven by medicated patients and associated with symptom severity. The anterior thalamus was also significantly smaller in patients after adjusting for thalamus size. Our results suggest that OCD-related thalamic volume differences are global and not driven by particular subregions and that the direction of effects are driven by both age and medication status.Authors & Co-authors: Weeland Cees J CJ Kasprzak Selina S de Joode Niels T NT Abe Yoshinari Y Alonso Pino P Ameis Stephanie H SH Anticevic Alan A Arnold Paul D PD Balachander Srinivas S Banaj Nerisa N Bargallo Nuria N Batistuzzo Marcelo C MC Benedetti Francesco F Beucke Jan C JC Bollettini Irene I Brecke Vilde V Brem Silvia S Cappi Carolina C Cheng Yuqi Y Cho Kang Ik K KIK Costa Daniel L C DLC Dallaspezia Sara S Denys Damiaan D Eng Goi Khia GK Ferreira Sónia S Feusner Jamie D JD Fontaine Martine M Fouche Jean-Paul JP Grazioplene Rachael G RG Gruner Patricia P He Mengxin M Hirano Yoshiyuki Y Hoexter Marcelo Q MQ Huyser Chaim C Hu Hao H Jaspers-Fayer Fern F Kathmann Norbert N Kaufmann Christian C Kim Minah M Koch Kathrin K Bin Kwak Yoo Y Kwon Jun Soo JS Lazaro Luisa L Li Chiang-Shan R CR Lochner Christine C Marsh Rachel R Martínez-Zalacaín Ignacio I Mataix-Cols David D Menchón Jose M JM Minnuzi Luciano L Moreira Pedro Silva PS Morgado Pedro P Nakagawa Akiko A Nakamae Takashi T Narayanaswamy Janardhanan C JC Nurmi Erika L EL Ortiz Ana E AE Pariente Jose C JC Piacentini John J Picó-Pérez Maria M Piras Fabrizio F Piras Federica F Pittenger Christopher C Reddy Y C Janardhan YCJ Rodriguez-Manrique Daniela D Sakai Yuki Y Shimizu Eiji E Shivakumar Venkataram V Simpson Helen Blair HB Soreni Noam N Soriano-Mas Carles C Sousa Nuno N Spalletta Gianfranco G Stern Emily R ER Stevens Michael C MC Stewart S Evelyn SE Szeszko Philip R PR Takahashi Jumpei J Tanamatis Tais T Tang Jinsong J Thorsen Anders Lillevik AL Tolin David D van der Werf Ysbrand D YD van Marle Hein H van Wingen Guido A GA Vecchio Daniela D Venkatasubramanian G G Walitza Susanne S Wang Jicai J Wang Zhen Z Watanabe Anri A Wolters Lidewij H LH Xu Xiufeng X Yun Je-Yeon JY Zhao Qing Q White Tonya T Thompson Paul M PM Stein Dan J DJ van den Heuvel Odile A OA Vriend Chris C
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Citations : Fawcett EJ, Power H, Fawcett JM. Women are at greater risk of OCD than men: a meta-analytic review of OCD prevalence worldwide. J Clin Psychiatry. 2020;81.Authors : 101
Identifiers
Doi : 70SSN : 2158-3188