Brain charts for the human lifespan.
Journal: Nature
Volume: 604
Issue: 7906
Year of Publication: 2022
Affiliated Institutions: Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK. rb@medschl.cam.ac.uk. Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA. jakob.seidlitz@pennmedicine.upenn.edu. Department of Psychiatry, University of Cambridge, Cambridge, UK. Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA. Department of Psychology, Yale University, New Haven, CT, USA. Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Victoria, Australia. UCL Great Ormond Street Institute for Child Health, London, UK. Weill Cornell Institute of Geriatric Psychiatry, Department of Psychiatry, Weill Cornell Medicine, New York, USA. Department of Pediatrics University of Toronto, Toronto, Canada. The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, University of Electronic Science and Technology of China, Chengdu, China. MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK. Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK. Queen's University, Department of Psychiatry, Centre for Neuroscience Studies, Kingston, Ontario, Canada. Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea. Centre for Addiction Medicine, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India. Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. Department of Human Genetics, South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg, TX, USA. MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK. Fetal and Neonatal Institute, Division of Neonatology, Children's Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. McGill Centre for Integrative Neuroscience, Ludmer Centre for Neuroinformatics and Mental Health, Montreal Neurological Institute, Montreal, Quebec, Canada. Department of Brain Sciences, Imperial College London, London, UK. Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, GA, USA. McGill University, Montreal, Quebec, Canada. Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Lifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia, PA, USA. Normandie Univ, UNICAEN, INSERM, U, PhIND "Physiopathology and Imaging of Neurological Disorders", Institut Blood and Brain @ Caen-Normandie, Cyceron, Caen, France. Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore. Centre for Medical Image Computing (CMIC), University College London, London, UK. Department of Psychiatry, Trinity College, Dublin, Ireland. Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, Quebec, Canada. Department of Neuroscience, University of California, San Diego, San Diego, CA, USA. Institute of Neurodegenerative Disorders, CNRS UMR, CEA, University of Bordeaux, Bordeaux, France. Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Victoria, Australia. The Hospital for Sick Children, Toronto, Ontario, Canada. Department of Psychiatry, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. Child and Adolescent Psychiatry Department, Robert Debré University Hospital, AP-HP, Paris, France. Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Cerebral Imaging Centre, McGill Department of Psychiatry, Douglas Mental Health University Institute, Montreal, QC, Canada. Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, London, UK. Division of Developmental Paediatrics, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa. Center for Neuroimaging, Cognition & Genomics (NICOG), School of Psychology, National University of Ireland Galway, Galway, Ireland. Weil Family Brain and Mind Research Institute, Department of Psychiatry, Weill Cornell Medicine, New York, NY, USA. Centre for the Developing Brain, King's College London, London, UK. Institute of Child Development, Department of Pediatrics, Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA. Department of Psychiatry, Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA. Desert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare, San Diego, CA, USA. Department of Psychiatry, University of Cambridge, and Wellcome Trust MRC Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK. Department of Clinical, Educational and Health Psychology, University College London, London, UK. Cuban Center for Neuroscience, La Habana, Cuba. Computational Radiology Laboratory, Boston Children's Hospital, Boston, MA, USA. Department of Child and Adolescent Psychiatry, University of California, San Diego, San Diego, CA, USA. Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA. Department of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. Division of Newborn Medicine and Neuroradiology, Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Weill Cornell Institute of Geriatric Psychiatry, Department of Psychiatry, Weill Cornell Medicine, New York, NY, USA. Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden. Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Berlin, Germany. Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. Department of Psychiatry, University of Cape Town, Cape Town, South Africa. Department of Integrative Medicine, NIMHANS, Bengaluru, India. Departments of Psychology and Psychiatry, Yale University, New Haven, CT, USA. Radiology Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA. Department of Psychiatry and Mental Health, Clinical Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Department of Radiology, Mayo Clinic, Rochester, MN, USA. Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil. Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China. Harvard Medical School, Boston, MA, USA. Department of Psychiatry, Icahn School of Medicine, Mount Sinai, NY, USA. Department of Clinical Medicine, Department of Psychiatry and Turku Brain and Mind Center, FinnBrain Birth Cohort Study, University of Turku and Turku University Hospital, Turku, Finland. Institute of Development, Aging and Cancer, Tohoku University, Seiryocho, Aobaku, Sendai, Japan. Queen's University, Departments of Psychology and Psychiatry, Centre for Neuroscience Studies, Kingston, Ontario, Canada. Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg, Sweden. Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea. Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK. Section on Developmental Neurogenomics, Human Genetics Branch, National Institute of Mental Health, Bethesda, MD, USA. Department of Brain & Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea. Mouse Imaging Centre, Toronto, Ontario, Canada. Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, China. Department of Psychiatry and Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA. Department of Psychology, University of Texas, Austin, TX, USA. Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, EURON, Maastricht University Medical Centre, Maastricht, The Netherlands. McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, Montreal, Quebec, Canada. Bordeaux University Hospital, Bordeaux, France. Department of Psychology, School of Business, National College of Ireland, Dublin, Ireland. Department of Psychiatry, School of Medicine, Oregon Health and Science University, Portland, OR, USA. Center for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Department of Pediatrics, Washington University in St Louis, St Louis, MO, USA. Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. Robarts Research Institute and The Brain and Mind Institute, University of Western Ontario, London, Ontario, Canada. Department of Psychiatry, Federal University of Sao Poalo (UNIFESP), Sao Poalo, Brazil. Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia. Department of Psychiatry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. Department of Psychiatry, Faculty of Medicine and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada. Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada. School of Psychology, Southwest University, Chongqing, China. Department of Biomedical Engineering, The N. Institute for Health, National University of Singapore, Singapore, Singapore. Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. Department of Neurology, Harvard Medical School, Boston, MA, USA. Department of Psychology and Neuroscience Institute, University of Chicago, Chicago, IL, USA. Department of Paediatrics and Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. Department of Psychiatry, Universidade Federal do Rio Grande do Sul (UFRGS), Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil. Otto Hahn Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. Centre for Population Neuroscience and Stratified Medicine (PONS), Institute for Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China. Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden. Departments of Neurology, Pediatrics, and Radiology, Washington University School of Medicine, St Louis, MO, USA. SA MRC Unit on Risk and Resilience in Mental Disorders, Dept of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. Université de Paris, Paris, France. Department of Neuroscience, Institut Pasteur, Paris, France. Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, U, CHU Bordeaux, Bordeaux, France. Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, Quebec, Canada. Institute for Neuroscience and Medicine , Forschungszentrum Jülich, Jülich, Germany. Department of Psychiatry and Neurosychology, Maastricht University, Maastricht, The Netherlands. Department of Biostatistics, Vanderbilt University, Nashville, TN, USA. Wellcome Centre for Human Neuroimaging, London, UK. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China. Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. Department of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore. Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, SA-MRC Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa. National Institute of Developmental Psychiatry for Children and Adolescents (INPD), Sao Poalo, Brazil.
Abstract summary
Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight. Here we assemble an interactive open resource to benchmark brain morphology derived from any current or future sample of MRI data ( http://www.brainchart.io/ ). With the goal of basing these reference charts on the largest and most inclusive dataset available, acknowledging limitations due to known biases of MRI studies relative to the diversity of the global population, we aggregated 123,984 MRI scans, across more than 100 primary studies, from 101,457 human participants between 115 days post-conception to 100 years of age. MRI metrics were quantified by centile scores, relative to non-linear trajectories of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones, showed high stability of individuals across longitudinal assessments, and demonstrated robustness to technical and methodological differences between primary studies. Centile scores showed increased heritability compared with non-centiled MRI phenotypes, and provided a standardized measure of atypical brain structure that revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. In summary, brain charts are an essential step towards robust quantification of individual variation benchmarked to normative trajectories in multiple, commonly used neuroimaging phenotypes.Authors & Co-authors: Bethlehem R A I RAI Seidlitz J J White S R SR Vogel J W JW Anderson K M KM Adamson C C Adler S S Alexopoulos G S GS Anagnostou E E Areces-Gonzalez A A Astle D E DE Auyeung B B Ayub M M Bae J J Ball G G Baron-Cohen S S Beare R R Bedford S A SA Benegal V V Beyer F F Blangero J J Blesa Cábez M M Boardman J P JP Borzage M M Bosch-Bayard J F JF Bourke N N Calhoun V D VD Chakravarty M M MM Chen C C Chertavian C C Chetelat G G Chong Y S YS Cole J H JH Corvin A A Costantino M M Courchesne E E Crivello F F Cropley V L VL Crosbie J J Crossley N N Delarue M M Delorme R R Desrivieres S S Devenyi G A GA Di Biase M A MA Dolan R R Donald K A KA Donohoe G G Dunlop K K Edwards A D AD Elison J T JT Ellis C T CT Elman J A JA Eyler L L Fair D A DA Feczko E E Fletcher P C PC Fonagy P P Franz C E CE Galan-Garcia L L Gholipour A A Giedd J J Gilmore J H JH Glahn D C DC Goodyer I M IM Grant P E PE Groenewold N A NA Gunning F M FM Gur R E RE Gur R C RC Hammill C F CF Hansson O O Hedden T T Heinz A A Henson R N RN Heuer K K Hoare J J Holla B B Holmes A J AJ Holt R R Huang H H Im K K Ipser J J Jack C R CR Jackowski A P AP Jia T T Johnson K A KA Jones P B PB Jones D T DT Kahn R S RS Karlsson H H Karlsson L L Kawashima R R Kelley E A EA Kern S S Kim K W KW Kitzbichler M G MG Kremen W S WS Lalonde F F Landeau B B Lee S S Lerch J J Lewis J D JD Li J J Liao W W Liston C C Lombardo M V MV Lv J J Lynch C C Mallard T T TT Marcelis M M Markello R D RD Mathias S R SR Mazoyer B B McGuire P P Meaney M J MJ Mechelli A A Medic N N Misic B B Morgan S E SE Mothersill D D Nigg J J Ong M Q W MQW Ortinau C C Ossenkoppele R R Ouyang M M Palaniyappan L L Paly L L Pan P M PM Pantelis C C Park M M MM Paus T T Pausova Z Z Paz-Linares D D Pichet Binette A A Pierce K K Qian X X Qiu J J Qiu A A Raznahan A A Rittman T T Rodrigue A A Rollins C K CK Romero-Garcia R R Ronan L L Rosenberg M D MD Rowitch D H DH Salum G A GA Satterthwaite T D TD Schaare H L HL Schachar R J RJ Schultz A P AP Schumann G G Schöll M M Sharp D D Shinohara R T RT Skoog I I Smyser C D CD Sperling R A RA Stein D J DJ Stolicyn A A Suckling J J Sullivan G G Taki Y Y Thyreau B B Toro R R Traut N N Tsvetanov K A KA Turk-Browne N B NB Tuulari J J JJ Tzourio C C Vachon-Presseau É É Valdes-Sosa M J MJ Valdes-Sosa P A PA Valk S L SL van Amelsvoort T T Vandekar S N SN Vasung L L Victoria L W LW Villeneuve S S Villringer A A Vértes P E PE Wagstyl K K Wang Y S YS Warfield S K SK Warrier V V Westman E E Westwater M L ML Whalley H C HC Witte A V AV Yang N N Yeo B B Yun H H Zalesky A A Zar H J HJ Zettergren A A Zhou J H JH Ziauddeen H H Zugman A A Zuo X N XN Bullmore E T ET Alexander-Bloch A F AF
Study Outcome
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Statistics
Citations : Cole TJ. The development of growth references and growth charts. Ann. Hum. Biol. 2012;39:382–394.Authors : 222
Identifiers
Doi : 10.1038/s41586-022-04554-ySSN : 1476-4687