Event-based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross-sectional data.
Journal: Epilepsia
Volume: 63
Issue: 8
Year of Publication: 2022
Affiliated Institutions:
Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK.
Department of Psychiatry, University of California, San Diego, La Jolla, California, USA.
Department of Neurology, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Department of Neurology and Neuroimaging Laboratory, University of Campinas, Campinas, Brazil.
Department of Radiology, Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
Department of Neurology, Emory University, Atlanta, USA.
Neuroscience Research Center, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Magnetic Resonance Image Core Facility, August Pi i Sunyer Biomedical Research Institute, University of Barcelona, Barcelona, Spain.
Institute of Neurobiology, National Autonomous University of Mexico, Querétaro, Mexico.
Epilepsy Program, Neurology Department, Hospital Clinic of Barcelona, Barcelona, Spain.
Radiology and Research Administration, Henry Ford Health System, Detroit, Michigan, USA.
Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.
New York University Grossman School of Medicine, New York, New York, USA.
Functional Imaging Unit, Department of Diagnostic Radiology and Neuroradiology, Greifswald University Medicine, Greifswald, Germany.
Department of Neurology, University Medical Center, Göttingen, Germany.
Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK.
Institute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK.
Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA.
Neuroscience Department, University of Florence, Florence, Italy.
Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Florey Institute of Neuroscience and Mental Health, Austin Campus, Heidelberg, Victoria, Australia.
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Pediatric Neurology, Neurogenetics and Neurobiology Unit and Laboratories, A. Meyer Children's Hospital, University of Florence, Florence, Italy.
Department of Neurology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Mario Serio Department of Clinical and Experimental Medical Sciences, University of Florence, Florence, Italy.
Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Department of Neurology, University of Campinas, Campinas, Brazil.
School of Computing, Newcastle University, Newcastle Upon Tyne, UK.
Division of Neuroscience, King's College London, London, UK.
Giannina Gaslini Institute, Scientific Institute for Research and Health Care, Genoa, Italy.
Department of Epileptology, University Hospital Bonn, Bonn, Germany.
Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Institute of Experimental Epileptology and Cognition Research, University of Bonn, Bonn, Germany.
Support Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Abstract summary
Recent work has shown that people with common epilepsies have characteristic patterns of cortical thinning, and that these changes may be progressive over time. Leveraging a large multicenter cross-sectional cohort, we investigated whether regional morphometric changes occur in a sequential manner, and whether these changes in people with mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS) correlate with clinical features.We extracted regional measures of cortical thickness, surface area, and subcortical brain volumes from T1-weighted (T1W) magnetic resonance imaging (MRI) scans collected by the ENIGMA-Epilepsy consortium, comprising 804 people with MTLE-HS and 1625 healthy controls from 25 centers. Features with a moderate case-control effect size (Cohen d ≥ .5) were used to train an event-based model (EBM), which estimates a sequence of disease-specific biomarker changes from cross-sectional data and assigns a biomarker-based fine-grained disease stage to individual patients. We tested for associations between EBM disease stage and duration of epilepsy, age at onset, and antiseizure medicine (ASM) resistance.In MTLE-HS, decrease in ipsilateral hippocampal volume along with increased asymmetry in hippocampal volume was followed by reduced thickness in neocortical regions, reduction in ipsilateral thalamus volume, and finally, increase in ipsilateral lateral ventricle volume. EBM stage was correlated with duration of illness (Spearman ρ = .293, p = 7.03 × 10 ), age at onset (ρ = -.18, p = 9.82 × 10 ), and ASM resistance (area under the curve = .59, p = .043, Mann-Whitney U test). However, associations were driven by cases assigned to EBM Stage 0, which represents MTLE-HS with mild or nondetectable abnormality on T1W MRI.From cross-sectional MRI, we reconstructed a disease progression model that highlights a sequence of MRI changes that aligns with previous longitudinal studies. This model could be used to stage MTLE-HS subjects in other cohorts and help establish connections between imaging-based progression staging and clinical features.
Authors & Co-authors:
Lopez Seymour M SM
Aksman Leon M LM
Oxtoby Neil P NP
Vos Sjoerd B SB
Rao Jun J
Kaestner Erik E
Alhusaini Saud S
Alvim Marina M
Bender Benjamin B
Bernasconi Andrea A
Bernasconi Neda N
Bernhardt Boris B
Bonilha Leonardo L
Caciagli Lorenzo L
Caldairou Benoit B
Caligiuri Maria Eugenia ME
Calvet Angels A
Cendes Fernando F
Concha Luis L
Conde-Blanco Estefania E
Davoodi-Bojd Esmaeil E
de Bézenac Christophe C
Delanty Norman N
Desmond Patricia M PM
Devinsky Orrin O
Domin Martin M
Duncan John S JS
Focke Niels K NK
Foley Sonya S
Fortunato Francesco F
Galovic Marian M
Gambardella Antonio A
Gleichgerrcht Ezequiel E
Guerrini Renzo R
Hamandi Khalid K
Ives-Deliperi Victoria V
Jackson Graeme D GD
Jahanshad Neda N
Keller Simon S SS
Kochunov Peter P
Kotikalapudi Raviteja R
Kreilkamp Barbara A K BAK
Labate Angelo A
Larivière Sara S
Lenge Matteo M
Lui Elaine E
Malpas Charles C
Martin Pascal P
Mascalchi Mario M
Medland Sarah E SE
Meletti Stefano S
Morita-Sherman Marcia E ME
Owen Thomas W TW
Richardson Mark M
Riva Antonella A
Rüber Theodor T
Sinclair Ben B
Soltanian-Zadeh Hamid H
Stein Dan J DJ
Striano Pasquale P
Taylor Peter N PN
Thomopoulos Sophia I SI
Thompson Paul M PM
Tondelli Manuela M
Vaudano Anna Elisabetta AE
Vivash Lucy L
Wang Yujiang Y
Weber Bernd B
Whelan Christopher D CD
Wiest Roland R
Winston Gavin P GP
Yasuda Clarissa Lin CL
McDonald Carrie R CR
Alexander Daniel C DC
Sisodiya Sanjay M SM
Altmann Andre A
Study Outcome
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