Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals.

Journal: Molecular psychiatry

Volume: 27

Issue: 9

Year of Publication: 2022

Affiliated Institutions:  Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany. Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech, Emory University, Atlanta, GA, USA. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain. Department of Psychiatry, School of Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Institute for Translational Psychiatry, University of Münster, Münster, Germany. Centre for Addiction & Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada. Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland. Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany. National Institute of Mental Health, Klecany, Czech Republic. Department of Psychiatry & Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA. School of Medicine, Universidad Finis Terrae, Santiago, Chile. Department of Psychology, Georgia State University, Atlanta, GA, USA. West Region, Institute of Mental Health, Singapore, Singapore. Department of Radiology, Marqués de Valdecilla University Hospital, Valdecilla Biomedical Research Institute IDIVAL, Santander, Spain. Early Intervention in Psychosis Program, Instituto Psiquiátrico 'Dr. José Horwitz B.', Santiago, Chile. Department of Psychology, University of Bath, Bath, UK. Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA. Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA. Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA. Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. tomas.hajek@dal.ca.

Abstract summary 

Schizophrenia is frequently associated with obesity, which is linked with neurostructural alterations. Yet, we do not understand how the brain correlates of obesity map onto the brain changes in schizophrenia. We obtained MRI-derived brain cortical and subcortical measures and body mass index (BMI) from 1260 individuals with schizophrenia and 1761 controls from 12 independent research sites within the ENIGMA-Schizophrenia Working Group. We jointly modeled the statistical effects of schizophrenia and BMI using mixed effects. BMI was additively associated with structure of many of the same brain regions as schizophrenia, but the cortical and subcortical alterations in schizophrenia were more widespread and pronounced. Both BMI and schizophrenia were primarily associated with changes in cortical thickness, with fewer correlates in surface area. While, BMI was negatively associated with cortical thickness, the significant associations between BMI and surface area or subcortical volumes were positive. Lastly, the brain correlates of obesity were replicated among large studies and closely resembled neurostructural changes in major depressive disorders. We confirmed widespread associations between BMI and brain structure in individuals with schizophrenia. People with both obesity and schizophrenia showed more pronounced brain alterations than people with only one of these conditions. Obesity appears to be a relevant factor which could account for heterogeneity of brain imaging findings and for differences in brain imaging outcomes among people with schizophrenia.

Authors & Co-authors:  McWhinney Sean R SR Brosch Katharina K Calhoun Vince D VD Crespo-Facorro Benedicto B Crossley Nicolas A NA Dannlowski Udo U Dickie Erin E Dietze Lorielle M F LMF Donohoe Gary G Du Plessis Stefan S Ehrlich Stefan S Emsley Robin R Furstova Petra P Glahn David C DC Gonzalez-Valderrama Alfonso A Grotegerd Dominik D Holleran Laurena L Kircher Tilo T J TTJ Knytl Pavel P Kolenic Marian M Lencer Rebekka R Nenadić Igor I Opel Nils N Pfarr Julia-Katharina JK Rodrigue Amanda L AL Rootes-Murdy Kelly K Ross Alex J AJ Sim Kang K Škoch Antonín A Spaniel Filip F Stein Frederike F Švancer Patrik P Tordesillas-Gutiérrez Diana D Undurraga Juan J Vázquez-Bourgon Javier J Voineskos Aristotle A Walton Esther E Weickert Thomas W TW Weickert Cynthia Shannon CS Thompson Paul M PM van Erp Theo G M TGM Turner Jessica A JA Hajek Tomas T

Study Outcome 

Source Link: Visit source

Statistics
Citations :  Whiteford HA, Degenhardt L, Rehm J, Baxter AJ, Ferrari AJ, Erskine HE, et al. Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet. 2013;382:1575–86.
Authors :  43
Identifiers
Doi : 10.1038/s41380-022-01616-5
SSN : 1476-5578
Study Population
Male,Female
Mesh Terms
Humans
Other Terms
Study Design
Cross Sectional Study
Study Approach
Mixed Methods
Country of Study
Publication Country
England