World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders - Version 3. Part I: Anxiety disorders.
Journal: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
Volume: 24
Issue: 2
Year of Publication: 2023
Affiliated Institutions:
Department of Psychiatry and Psychotherapy, University Medical Center, Göttingen, Germany.
Department of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden.
Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Department and Institute of Psychiatry, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil.
Afdeling Psychiatrie, Universitair Medische Centra, Amsterdam, The Netherlands.
Psikiyatri Uzmanı, Üsküdar Üniversitesi Tıp Fakültesi Psikiyatri ABD, İstanbul, Turkey.
Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Department of Pharmacology, University of Gothenburg, Gothenburg, Sweden.
School of Life and Medical Sciences, University of Hertfordshire, Hertfordshire, United Kingdom.
Treatment Center for Anxiety and Depression, Zürich, Switzerland.
Albert Einstein College of Medicine, New York, NY, USA.
Department of Psychiatry, Kyoto Prefactual Medical College, Kyoto, Japan.
V. M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Ministry of Health, Federal State Budgetary Institution of Higher Education, St. Petersburg State Pediatric Medical University, St. Petersburg, Russia.
Clinical Division of General Psychiatry, Medical University of Vienna, Vienna, Austria.
S.T.A.R.T. Clinic, Toronto, Canada.
Department of Psychiatry, College of Medicine, Korea University, Seoul, Korea.
Department of Psychiatry, Tokyo Medical University, Tokyo, Japan.
Department of Psychiatry, Singapore General Hospital, Bukit Merah, Singapore.
First Department of Psychiatry, Eginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Department of Psychiatry, Bellvitge University Hospital-IDIBELL, University of Barcelona, Cibersam, Barcelona, Spain.
Department of Psychiatry, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Department of Psychiatry and Psychotherapy, University of München, Munich, Germany.
Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Istituto die Neuroscienze, University of Florence, Firenze, Italy.
Department of Biological Sciences, Humanitas University Pieve Emanuele, Milano, Italy.
Faculty of Medicine and Health, Sydney Medical School, Nepean Clinical School, University of Sydney, Sydney, Australia.
SA MRC Unit on Risk and Resilience in Mental Disorders, Department Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada.
V. M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Ministry of Health, I.I. Mechnikov North-Western State Medical University, St. Petersburg, Russia.
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chaim Sheba Medical Center, Tel Aviv, Israel.
Abstract summary
This is the third version of the guideline of the World Federation of Societies of Biological Psychiatry (WFSBP) Task Force for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Posttraumatic Stress Disorders (published in 2002, revised in 2008).A consensus panel of 33 international experts representing 22 countries developed recommendations based on efficacy and acceptability of available treatments. In total, 1007 RCTs for the treatment of these disorders in adults, adolescents, and children with medications, psychotherapy and other non-pharmacological interventions were evaluated, applying the same rigorous methods that are standard for the assessment of medications.This paper, Part I, contains recommendations for the treatment of panic disorder/agoraphobia (PDA), generalised anxiety disorder (GAD), social anxiety disorder (SAD), specific phobias, mixed anxiety disorders in children and adolescents, separation anxiety and selective mutism. Selective serotonin reuptake inhibitors (SSRI) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are first-line medications. Cognitive behavioural therapy (CBT) is the first-line psychotherapy for anxiety disorders. The expert panel also made recommendations for patients not responding to standard treatments and recommendations against interventions with insufficient evidence.It is the goal of this initiative to provide treatment guidance for these disorders that has validity throughout the world.
Authors & Co-authors:
Bandelow Borwin B
Allgulander Christer C
Baldwin David S DS
Costa Daniel Lucas da Conceição DLDC
Denys Damiaan D
Dilbaz Nesrin N
Domschke Katharina K
Eriksson Elias E
Fineberg Naomi A NA
Hättenschwiler Josef J
Hollander Eric E
Kaiya Hisanobu H
Karavaeva Tatiana T
Kasper Siegfried S
Katzman Martin M
Kim Yong-Ku YK
Inoue Takeshi T
Lim Leslie L
Masdrakis Vasilios V
Menchón José M JM
Miguel Euripedes C EC
Möller Hans-Jürgen HJ
Nardi Antonio E AE
Pallanti Stefano S
Perna Giampaolo G
Rujescu Dan D
Starcevic Vladan V
Stein Dan J DJ
Tsai Shih-Jen SJ
Van Ameringen Michael M
Vasileva Anna A
Wang Zhen Z
Zohar Joseph J
Study Outcome
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