Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-analysis.

Journal: Journal of the American Academy of Child and Adolescent Psychiatry

Volume: 61

Issue: 9

Year of Publication: 2022

Affiliated Institutions:  Leiden University, Leiden, the Netherlands; Leiden University Medical Center, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands; National Institute of Mental Health, Bethesda, Maryland. Electronic address: j.m.hoogendam@fsw.leidenuniv.nl. National Institute of Mental Health, Bethesda, Maryland. Pennsylvania State University, University Park. Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Federal University of São Paulo, São Paulo, Brazil. The Catholic University of America, Washington, DC. National Institute of Mental Health, Bethesda, Maryland; University of Maryland, College Park. University of Maryland, College Park. University of Waterloo, Waterloo, Ontario, Canada. Erasmus University Rotterdam, Rotterdam, the Netherlands. Erasmus University Medical Center, Rotterdam, the Netherlands. University College London, United Kingdom. Massachusetts General Hospital, Harvard Medical School, Boston. Tufts University, Medford, Massachusetts. Radboud University Nijmegen, the Netherlands. University of Pittsburgh School of Medicine, Pennsylvania. University of Toronto, Ontario, Canada; Centre for Addiction and Mental Health, Toronto, Ontario, Canada. University of Trento, Rovereto, Italy. University of Hong Kong, Hong Kong. Stony Brook University, New York. Vanderbilt University Medical Center, Nashville, Tennessee. Vanderbilt University Medical Center, Nashville, Tennessee; University of Nebraska Medical Center, Omaha. Western University, London, Ontario, Canada. Western University, London, Ontario, Canada; North Dakota State University, Fargo. University of Wisconsin-Madison. University of Oxford, United Kingdom. University of Southern California, Marina del Rey. Leiden University, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands. Leiden University Medical Center, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands. University of Cape Town, Cape Town, South Africa.

Abstract summary 

Temperament involves stable behavioral and emotional tendencies that differ between individuals, which can be first observed in infancy or early childhood and relate to behavior in many contexts and over many years. One of the most rigorously characterized temperament classifications relates to the tendency of individuals to avoid the unfamiliar and to withdraw from unfamiliar people, objects, and unexpected events. This temperament is referred to as behavioral inhibition or inhibited temperament (IT). IT is a moderately heritable trait that can be measured in multiple species. In humans, levels of IT can be quantified from the first year of life through direct behavioral observations or reports by caregivers or teachers. Similar approaches as well as self-report questionnaires on current and/or retrospective levels of IT can be used later in life.

Authors & Co-authors:  Bas-Hoogendam Janna Marie JM Bernstein Rachel R Benson Brenda E BE Buss Kristin A KA Gunther Kelley E KE Pérez-Edgar Koraly K Salum Giovanni A GA Jackowski Andrea P AP Bressan Rodrigo A RA Zugman André A Degnan Kathryn A KA Filippi Courtney A CA Fox Nathan A NA Henderson Heather A HA Tang Alva A Zeytinoglu Selin S Harrewijn Anita A Hillegers Manon H J MHJ White Tonya T van IJzendoorn Marinus H MH Schwartz Carl E CE Felicione Julia M JM DeYoung Kathryn A KA Shackman Alexander J AJ Smith Jason F JF Tillman Rachael M RM van den Berg Yvonne H M YHM Cillessen Antonius H N AHN Roelofs Karin K Tyborowska Anna A Hill Shirley Y SY Battaglia Marco M Tettamanti Marco M Dougherty Lea R LR Jin Jingwen J Klein Daniel N DN Leung Hoi-Chung HC Avery Suzanne N SN Blackford Jennifer Urbano JU Clauss Jacqueline A JA Hayden Elizabeth P EP Liu Pan P Vandermeer Matthew R J MRJ Goldsmith H Hill HH Planalp Elizabeth M EM Nichols Thomas E TE Thompson Paul M PM Westenberg P Michiel PM van der Wee Nic J A NJA Groenewold Nynke A NA Stein Dan J DJ Winkler Anderson M AM Pine Daniel S DS

Study Outcome 

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Statistics
Citations :  Clauss JA, Avery SN, Blackford JU. The nature of individual differences in inhibited temperament and risk for psychiatric disease: A review and meta-analysis. Prog Neurobiol. 2015;127–128:23–45. 10.1016/j.pneurobio.2015.03.001
Authors :  54
Identifiers
Doi : 10.1016/j.jaac.2022.04.023
SSN : 1527-5418
Study Population
Male,Female
Mesh Terms
Anxiety
Other Terms
Study Design
Cross Sectional Study
Study Approach
Country of Study
Publication Country
United States