Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium.

Journal: Journal of affective disorders

Volume: 318

Issue: 

Year of Publication: 2022

Affiliated Institutions:  Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, the Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam, the Netherlands. Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. Department of Clinical Sciences, Bellvitge Biomedical Research Institute-IDIBELL, CIBERSAM, Bellvitge University Hospital, Barcelona, Spain. The Margaret and Wallace McCain Centre for Child, Youth & Family Mental Health, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Canada. The Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Obsessive-Compulsive Disorder (OCD) Clinic, Department of Psychiatry, National Institute of Mental Health & Neurosciences, Bangalore, India. McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, MA, USA. Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy. Magnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Image Diagnostic Center, Hospital Clinic of Barcelona, Barcelona, Spain. Departamento e Instituto de Psiquiatria do Hospital das Clinicas, IPQ HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, SP, Brazil; Department of Methods and Techniques in Psychology, Pontifical Catholic University of Sao Paulo, SP, Brazil. Vita-Salute San Raffaele University, Milano, Italy; Departments of Psychiatry and Medical Genetics, IRCCS Scientific Institute Ospedale San Raffaele, Milan, Italy. Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden. Departments of Psychiatry and Medical Genetics, IRCCS Scientific Institute Ospedale San Raffaele, Milan, Italy. Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland. Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands. Department of Child and Adolescent Psychiatry and Psychology, Hospital Clínic of Barcelona (CIBERSAM), Department of Medicine, University of Barcelona, Barcelona, Spain. Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China. Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Brain and Cognitive Sciences, Seoul University College of Natural Science, Seoul, Republic of Korea. Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, the Netherlands. Departamento e Instituto de Psiquiatria do Hospital das Clinicas, IPQ HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, SP, Brazil. Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, New York, NY, USA. Division of Neurosciences & Clinical Translation, Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Staglin IMHRO Center for Cognitive Neuroscience, Jane & Terry Semel institute For Neurosciences, University of California, Los Angeles, CA, USA. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, ICVS/B's PT Government Associate Laboratory, Clinical Academic Center, Braga, Portugal. Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA. Columbia University Irving Medical Center, Columbia University, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA. Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. Research Center for Child Mental Development, Chiba University, Chiba, Japan. Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, the Netherlands; Levvel Academic Center for Child and Adolescent Psychiatry, Amsterdam, the Netherlands. Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Department of Psychiatry, Oxford University, Oxford, UK. Britsh Columbia Children's Hospital, BC Mental Health and Substance Use Services Research, University of British Columbia, Vancouver, BC, Canada. Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany. Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea. Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Germany. Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Brain and Cognitive Sciences, Seoul University College of Natural Science, Seoul, Republic of Korea; Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea. SAMRC Unit on Anxiety & Stress Disorders, Department of Psychiatry, Stellenbosch University, South Africa. Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden. Department of Psychiatry and Behavioral Neurosciences, McMaster University, St. Joseph's Health Care, Hamilton, Ontario, Canada. Division of Child and Adolescent Psychiatry, Jane & Terry Semel Institute For Neurosciences, University of California, Los Angeles, CA, USA; Staglin IMHRO Center for Cognitive Neuroscience, Jane & Terry Semel institute For Neurosciences, University of California, Los Angeles, CA, USA. Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Psychiatry, Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Gyeonggi-do, Republic of Korea. University of Illinois at Urbana-Champaign, Champaign, IL, USA. Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan; ATR Brain Information Communication Research Laboratiry Group, Kyoto, Japan. Pediatric OCD Consultation Service, Anxiety Treatment and Research Center, Offord Center of Child Studies, Hamilton, Ontario, Canada. Department of Clinical Sciences, Bellvitge Biomedical Research Institute-IDIBELL, CIBERSAM, Bellvitge University Hospital, Barcelona, Spain; Department of Social Psychology and Quantitative Psychology, Universitat de Barcelona- UB, Barcelona,Spain. Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy; Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Science, Baylor College of Medicine, Houston, TX, USA. Department of Psychiatry, New York University Langone School of Medicine, New York, NY, USA. Institute of Living/Hartford Hospital, Hartford, CT, USA; Yale University School of Medicine, New Haven, CT, USA. Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine, China. Institute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran. Magnetic Resonance Image Center, First Affiliated Hospital of Kunming Medical University, Kunming, China. Imaging Genetics Center, Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, South Africa.

Abstract summary 

Widely used psychotropic medications for obsessive-compulsive disorder (OCD) may change the volumes of subcortical brain structures, and differently in children vs. adults. We measured subcortical volumes cross-sectionally in patients finely stratified for age taking various common classes of OCD drugs.The ENIGMA-OCD consortium sample (1081 medicated/1159 unmedicated OCD patients and 2057 healthy controls aged 6-65) was divided into six successive 6-10-year age-groups. Individual structural MRIs were parcellated automatically using FreeSurfer into 8 regions-of-interest (ROIs). ROI volumes were compared between unmedicated and medicated patients and controls, and between patients taking serotonin reuptake inhibitors (SRIs), tricyclics (TCs), antipsychotics (APs), or benzodiazepines (BZs) and unmedicated patients.Compared to unmedicated patients, volumes of accumbens, caudate, and/or putamen were lower in children aged 6-13 and adults aged 50-65 with OCD taking SRIs (Cohen's d = -0.24 to -0.74). Volumes of putamen, pallidum (d = 0.18-0.40), and ventricles (d = 0.31-0.66) were greater in patients aged 20-29 receiving APs. Hippocampal volumes were smaller in patients aged 20 and older taking TCs and/or BZs (d = -0.27 to -1.31).Results suggest that TCs and BZs could potentially aggravate hippocampal atrophy of normal aging in older adults with OCD, whereas SRIs may reduce striatal volumes in young children and older adults. Similar to patients with psychotic disorders, OCD patients aged 20-29 may experience subcortical nuclear and ventricular hypertrophy in relation to APs. Although cross-sectional, present results suggest that commonly prescribed agents exert macroscopic effects on subcortical nuclei of unknown relation to therapeutic response.

Authors & Co-authors:  Ivanov Iliyan I Boedhoe Premika S W PSW Abe Yoshinari Y Alonso Pino P Ameis Stephanie H SH Arnold Paul D PD Balachander Srinivas S Baker Justin T JT Banaj Nerisa N Bargalló Nuria N Batistuzzo Marcelo C MC Benedetti Francesco F Beucke Jan C JC Bollettini Irene I Brem Silvia S Brennan Brian P BP Buitelaar Jan J Calvo Rosa R Cheng Yuqi Y Cho Kang Ik K KIK Dallaspezia Sara S Denys Damiaan D Diniz Juliana B JB Ely Benjamin A BA Feusner Jamie D JD Ferreira Sónia S Fitzgerald Kate D KD Fontaine Martine M Gruner Patricia P Hanna Gregory L GL Hirano Yoshiyuki Y Hoexter Marcelo Q MQ Huyser Chaim C Ikari Keisuke K James Anthony A Jaspers-Fayer Fern F Jiang Hongyan H Kathmann Norbert N Kaufmann Christian C Kim Minah M Koch Kathrin K Kwon Jun Soo JS Lázaro Luisa L Liu Yanni Y Lochner Christine C Marsh Rachel R Martínez-Zalacaín Ignacio I Mataix-Cols David D Menchón José M JM Minuzzi Luciano L Morer Astrid A Morgado Pedro P Nakagawa Akiko A Nakamae Takashi T Nakao Tomohiro T Narayanaswamy Janardhanan C JC Nurmi Erika L EL Oh Sanghoon S Perriello Chris C Piacentini John C JC Picó-Pérez Maria M Piras Fabrizio F Piras Federica F Reddy Y C Janardhan YCJ Manrique Daniela Rodriguez DR Sakai Yuki Y Shimizu Eiji E Simpson H Blair HB Soreni Noam N Soriano-Mas Carles C Spalletta Gianfranco G Stern Emily R ER Stevens Michael C MC Stewart S Evelyn SE Szeszko Philip R PR Tolin David F DF van Rooij Daan D Veltman Dick J DJ van der Werf Ysbrand D YD van Wingen Guido A GA Venkatasubramanian Ganesan G Walitza Susanne S Wang Zhen Z Watanabe Anri A Wolters Lidewij H LH Xu Xiufeng X Yun Je-Yeon JY Zarei Mojtaba M Zhang Fengrui F Zhao Qing Q Jahanshad Neda N Thomopoulos Sophia I SI Thompson Paul M PM Stein Dan J DJ van den Heuvel Odile A OA O'Neill Joseph J

Study Outcome 

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Citations : 
Authors :  97
Identifiers
Doi : 10.1016/j.jad.2022.08.084
SSN : 1573-2517
Study Population
Male,Female
Mesh Terms
Aged
Other Terms
Age;Benzodiazepines;OCD;Psychotropics;SRIs;Subcortical volumes
Study Design
Cross Sectional Study
Study Approach
Country of Study
Publication Country
Netherlands