Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS): A worldwide platform for collaboration.
Journal: Frontiers in psychiatry
Volume: 13
Issue:
Year of Publication:
Affiliated Institutions:
Department of Biological Sciences, Purdue University, West Lafayette, IN, United States.
Department of Psychiatry, Hannover University Medical School, Hannover, Germany.
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Radiology Unit , Department of Medical Surgical Sciences and Advanced Technologies, University of Catania, Catania, Italy.
University Medical Center Groningen, Department of Psychiatry, University of Groningen, Groningen, Netherlands.
Department of Child and Adolescent Psychiatry, Technische Universität (TU) Dresden, Dresden, Germany.
Department of Pediatrics, Herlev University Hospital, Herlev, Denmark.
Department of Neurophysiology, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.
Pitié-Salpêtrière Hospital, Paris, France.
Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/University of Seville, Seville, Spain.
Department of Psychiatry, Psychotherapy and Psychosomatic, RWTH Aachen University, Aachen, Germany.
Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway.
Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai, China.
Department of Psychiatry, Medical University of Warsaw, Warsaw, Poland.
Institute of Systems Motor Science, University of Lübeck, Lübeck, Germany.
Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Munich, Germany.
Deakin University, Geelong, VIC, Australia.
Wake Forest School of Medicine, Winston-Salem, NC, United States.
Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, United States.
Centre for Innovation in Mental Health, School of Psychology, University of Southampton, Southampton, United Kingdom.
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands.
Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany.
Department of Cognitive Science, University of California, San Diego, La Jolla, CA, United States.
Department of Neurology, Medical University of Warsaw, Warsaw, Poland.
Child and Adolescent Neurology and Psychiatric Section, Department of Clinical and Experimental Medicine, Catania University, Catania, Italy.
Child Neuropsychiatry Unit, Department of Clinical and Experimental Medicine, School of Medicine, University of Catania, Catania, Italy.
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Child Psychiatry, Medical University of Warsaw, Warsaw, Poland.
Department of Computer Science, Purdue University, West Lafayette, IN, United States.
Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, Netherlands.
Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, Netherlands.
Centre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia.
South African Medical Research Council (SAMRC) Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Department Psychiatry, Department Anatomy and Neuroscience, Amsterdam University Medical Center (UMC), Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, Netherlands.
Abstract summary
Tourette syndrome (TS) is characterized by multiple motor and vocal tics, and high-comorbidity rates with other neuropsychiatric disorders. Obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), major depressive disorder (MDD), and anxiety disorders (AXDs) are among the most prevalent TS comorbidities. To date, studies on TS brain structure and function have been limited in size with efforts mostly fragmented. This leads to low-statistical power, discordant results due to differences in approaches, and hinders the ability to stratify patients according to clinical parameters and investigate comorbidity patterns. Here, we present the scientific premise, perspectives, and key goals that have motivated the establishment of the Enhancing Neuroimaging Genetics through Meta-Analysis for TS (ENIGMA-TS) working group. The ENIGMA-TS working group is an international collaborative effort bringing together a large network of investigators who aim to understand brain structure and function in TS and dissect the underlying neurobiology that leads to observed comorbidity patterns and clinical heterogeneity. Previously collected TS neuroimaging data will be analyzed jointly and integrated with TS genomic data, as well as equivalently large and already existing studies of highly comorbid OCD, ADHD, ASD, MDD, and AXD. Our work highlights the power of collaborative efforts and transdiagnostic approaches, and points to the existence of different TS subtypes. ENIGMA-TS will offer large-scale, high-powered studies that will lead to important insights toward understanding brain structure and function and genetic effects in TS and related disorders, and the identification of biomarkers that could help inform improved clinical practice.
Authors & Co-authors:
Paschou Peristera P
Jin Yin Y
Müller-Vahl Kirsten K
Möller Harald E HE
Rizzo Renata R
Hoekstra Pieter J PJ
Roessner Veit V
Mol Debes Nanette N
Worbe Yulia Y
Hartmann Andreas A
Mir Pablo P
Cath Danielle D
Neuner Irene I
Eichele Heike H
Zhang Chencheng C
Lewandowska Katarzyna K
Munchau Alexander A
Verrel Julius J
Musil Richard R
Silk Tim J TJ
Hanlon Colleen A CA
Bihun Emily D ED
Brandt Valerie V
Dietrich Andrea A
Forde Natalie N
Ganos Christos C
Greene Deanna J DJ
Chu Chunguang C
Grothe Michel J MJ
Hershey Tamara T
Janik Piotr P
Koller Jonathan M JM
Martin-Rodriguez Juan Francisco JF
Müller Karsten K
Palmucci Stefano S
Prato Adriana A
Ramkiran Shukti S
Saia Federica F
Szejko Natalia N
Torrecuso Renzo R
Tumer Zeynep Z
Uhlmann Anne A
Veselinovic Tanja T
Wolańczyk Tomasz T
Zouki Jade-Jocelyne JJ
Jain Pritesh P
Topaloudi Apostolia A
Kaka Mary M
Yang Zhiyu Z
Drineas Petros P
Thomopoulos Sophia I SI
White Tonya T
Veltman Dick J DJ
Schmaal Lianne L
Stein Dan J DJ
Buitelaar Jan J
Franke Barbara B
van den Heuvel Odile O
Jahanshad Neda N
Thompson Paul M PM
Black Kevin J KJ
Study Outcome
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