Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders.

Journal: Nature communications

Volume: 13

Issue: 1

Year of Publication: 2022

Affiliated Institutions:  Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. m.hettwer@fz-juelich.de. Multimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada. Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neuroscience and Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands. Centre for Youth Mental Health, The University of Melbourne, Melbourne, VIC, Australia. NORMENT Centre, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway. Imaging Genetics Center, Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA. Departments of Psychiatry and Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands. Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands. South African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine Hall, Irvine, CA, USA. Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK. Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. s.valk@fz-juelich.de.

Abstract summary 

Neuropsychiatric disorders are increasingly conceptualized as overlapping spectra sharing multi-level neurobiological alterations. However, whether transdiagnostic cortical alterations covary in a biologically meaningful way is currently unknown. Here, we studied co-alteration networks across six neurodevelopmental and psychiatric disorders, reflecting pathological structural covariance. In 12,024 patients and 18,969 controls from the ENIGMA consortium, we observed that co-alteration patterns followed normative connectome organization and were anchored to prefrontal and temporal disease epicenters. Manifold learning revealed frontal-to-temporal and sensory/limbic-to-occipitoparietal transdiagnostic gradients, differentiating shared illness effects on cortical thickness along these axes. The principal gradient aligned with a normative cortical thickness covariance gradient and established a transcriptomic link to cortico-cerebello-thalamic circuits. Moreover, transdiagnostic gradients segregated functional networks involved in basic sensory, attentional/perceptual, and domain-general cognitive processes, and distinguished between regional cytoarchitectonic profiles. Together, our findings indicate that shared illness effects occur in a synchronized fashion and along multiple levels of hierarchical cortical organization.

Authors & Co-authors:  Hettwer M D MD Larivière S S Park B Y BY van den Heuvel O A OA Schmaal L L Andreassen O A OA Ching C R K CRK Hoogman M M Buitelaar J J van Rooij D D Veltman D J DJ Stein D J DJ Franke B B van Erp T G M TGM Jahanshad N N Thompson P M PM Thomopoulos S I SI Bethlehem R A I RAI Bernhardt B C BC Eickhoff S B SB Valk S L SL

Study Outcome 

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Citations :  Dell’Osso L, Lorenzi P, Carpita B. The neurodevelopmental continuum towards a neurodevelopmental gradient hypothesis. J. Psychopathol. 2019;25:179–182.
Authors :  27
Identifiers
Doi : 6851
SSN : 2041-1723
Study Population
Male,Female
Mesh Terms
Humans
Other Terms
Study Design
Cross Sectional Study
Study Approach
Country of Study
Publication Country
England