Neuropsychiatric Consequences of COVID-19 Pandemic: A Synthetic Review from a Global Perspective.
Journal: Alpha psychiatry
Volume: 23
Issue: 4
Year of Publication:
Affiliated Institutions:
Somnogen Canada Inc., College Street, Toronto, Canada.
Sleep research unit, Department of Psychiatry, Faculty of Medicine, Mansoura University, Egypt.
Department of Rehabilitation Medicine, North Area -Armed Forces Hospital (NAAFH)-KSA, Saudi Arabia.
Department of Chest Medicine, Faculty of Medicine, Mansoura University, Egypt.
Department of Nursing, College of Applied Medical Sciences, Majmaah University, Majmaah, Saudi Arabia.
University Sleep Disorders Center, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Kingdom of Bahrain.
Division of Community Psychiatry, M. S. Chellamuthu Trust and Research Foundation, Madurai, India.
Independent Researcher, Narayanapuram, Madurai, Tamil Nadu, India.
Department of Psychiatry, Chulalongkorn University Faculty of Medicine, Bangkok, Thailand.
Department of Psychiatry, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Medicine, Columbia University, New York, NY, USA.
Department of Psychiatry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Department of Neuropsychiatry and Behavioral Science, Columbia, University of South Carolina, South Carolina, USA.
Department of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, Texas USA.
The Institute for Mental and Physical Health and Clinical Translation Strategy Research Centre, Deakin University School of Medicine, Geelong Victoria, Australia.
School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, South Africa.
Neuroscience Education Institute, University of California San Diego, San Diego, CA, USA.
Departments of Psychiatry, Neuroscience, and Pharmacological Sciences, Mount Sinai School of Medicine, New York, NY, USA.
Abstract summary
Some research suggests that distress, secondary to isolation and fear following COVID-19 infection, can negatively affect the long-term more than the COVID-19 infection itself. This narrative review aims to provide a global view on the neuropsychiatric consequences of COVID-19 that can be ascribed to several factors, ranging from the direct effect of infection, to the body's responses against the infection, or to the psychological sequelae of social isolation, unemployment, and fear for one's health and livelihood. Current findings show that the more severe the respiratory infection, the more likely are central nervous system (CNS) complications regarding the infection itself. The immune reactions to the infection may result in symptoms similar to chronic fatigue as well as neurocognitive deficits, which last long after the infection is gone. An increase in symptoms of depression, anxiety, and trauma-related stress may also follow upon economic fears and isolation from friends and family. The consequences of the pandemic are not limited to adults; children learning remotely and away from classmates and routine activities may develop adjustment disorders, acute stress disorder, and a variety of manifestations of grief. A summary of case reports suggests that COVID-19-related stress, economic recession, and political unrest increase the risk of suicidal behaviors and acts of violence. However, it is unknown whether manifestations of mental disorders result from social causes or whether CNS complications may be responsible.
Authors & Co-authors:
Pandi-Perumal Seithikurippu R SR
Zaki Nevin F W NFW
Qasim Mohammad M
Elsayed Morsy Nesreen N
Manzar Md Dilshad MD
BaHammam Ahmed S AS
Jahrami Haitham H
Ramasubramanian Chellamuthu C
Karthikeyan Ramanujam R
Supasitthumrong Thitiporn T
Moscovitch Adam A
Trakht Ilya I
Gupta Ravi R
Narasimhan Meera M
Partonen Timo T
Reiter Russel J RJ
Morris Gerwyn G
Berk Michael M
Kennedy Sidney H SH
Stein Dan J DJ
Stahl Stephen M SM
Charney Dennis S DS
Seeman Mary V MV
Study Outcome
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