Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group.
Journal: Molecular psychiatry
Volume: 28
Issue: 3
Year of Publication: 2023
Affiliated Institutions:
Neuroscience Institute, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa. nynke.groenewold@uct.ac.za.
Department of Psychiatry, Leiden University Medical Center, Leiden, Netherlands.
Neuroscience Institute, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Orygen & Centre for Youth Mental Health, The University of Melbourne, Melbourne, VIC, Australia.
Leiden University, Institute of Education & Child Studies, Section Forensic Family & Youth Care, Leiden, Netherlands.
Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
LiNC, Department of Psychiatry, Federal University of São Paulo, São Paulo, SP, Brazil.
Section on Negative Affect and Social Processes, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Child and Adolescent Mental Health Centre, Mental Health Services, Capital Region of Denmark, Copenhagen, Denmark.
Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, USA.
Departments of Psychiatry & Neurobiology, Yale School of Medicine, New Haven, CT, USA.
Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.
Donders Institute for Brain, Cognition and Behavior, Radboud University Behavioral Science Institute, Radboud University, Nijmegen, Netherlands.
Wellcome Centre for Integrative Neuroimaging Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK.
MRI Research Unit, Department of Radiology, Hospital del Mar, Barcelona, Spain.
Department of Mental Health, University Hospital Parc Taulí-IPT, Barcelona, Spain, Barcelona, Spain.
Behavioral Epidemiology, Institute of Clinical Psycholog and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Core-Facility Brainimaging, Faculty of Medicine, University of Marburg, Marburg, Germany.
Department of Psychiatry, University of Marburg, Marburg, Germany.
Institute for Translational Psychiatry, University of Münster, Münster, Germany.
Department of Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany.
Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health (TüCMH), University of Tübingen, Tübingen, Germany.
Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital of Sichuan University, Chengdu, China.
Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
Department of Physiology, Istanbul University, Istanbul, Turkey.
Department of Psychiatry, Istanbul University, Istanbul, Turkey.
Department of Developmental and Educational Psychology, Institute of Psychology, Leiden University, Leiden, Netherlands.
Psychological Science Research Institute, Université Catholique de Louvain, Louvain-la-Neuve, Belgium.
Department of Clinical Psychology, University of Amsterdam, Amsterdam, Netherlands.
Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany.
Division of Nuclear Medicine, Stellenbosch University, Stellenbosch, South Africa.
SA-MRC Unit on Risk and Resilience in Mental Disorders, Stellenbosch University, Stellenbosch, South Africa.
Institute of Systems Medicine and Faculty of Human Medicine, MSH Medical School Hamburg, Hamburg, Germany.
Cognitive Neuroscience Center, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Department of Psychology, Vanderbilt University, Nashville, TN, USA.
Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Department of Psychiatry and Human Behavior, Brown University Warren Alpert Medical School, Providence, RI, USA.
Institute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
University Clinic for Radiology, University of Münster, Münster, Germany.
KBO-Inn-Salzach-Klinikum, Munich, Germany.
Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Department of Psychiatry and Behavioral Sciences, The University of Texas at Austin Dell Medical School, Austin, TX, USA.
Laureate Institute for Brain Research, Tulsa, OK, USA.
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Departments of Psychiatry & School of Public Health, University of California, San Diego, La Jolla, CA, USA.
Departments of Psychology & Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
Department of Psychiatry & Behavioral Health, the Ohio State University, Columbus, OH, USA.
Department of Psychology, Uppsala University, Uppsala, Sweden.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA.
Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Department of Psychiatry, Washington University, St. Louis, MO, USA.
Department of Psychiatry, Amsterdam UMC location VUMC, Amsterdam, Netherlands.
Abstract summary
There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = -0.077, p = 0.037; right: d = -0.104, p = 0.001), and a significant interaction between SAD and age was found for the left putamen (r = -0.034, p = 0.045). Smaller bilateral putamen volumes (left: d = -0.141, p < 0.001; right: d = -0.158, p < 0.001) and larger bilateral pallidum volumes (left: d = 0.129, p = 0.006; right: d = 0.099, p = 0.046) were detected in adult SAD patients relative to controls, but no volumetric differences were apparent in adolescent SAD patients relative to controls. Comorbid anxiety disorders and age of SAD onset were additional determinants of SAD-related volumetric differences in subcortical regions. To conclude, subtle volumetric alterations in subcortical regions in SAD were detected. Heterogeneity in age and clinical characteristics may partly explain inconsistencies in previous findings. The association between alterations in subcortical volumes and SAD illness progression deserves further investigation, especially from adolescence into adulthood.
Authors & Co-authors:
Groenewold Nynke A NA
Bas-Hoogendam Janna Marie JM
Amod Alyssa R AR
Laansma Max A MA
Van Velzen Laura S LS
Aghajani Moji M
Hilbert Kevin K
Oh Hyuntaek H
Salas Ramiro R
Jackowski Andrea P AP
Pan Pedro M PM
Salum Giovanni A GA
Blair James R JR
Blair Karina S KS
Hirsch Joy J
Pantazatos Spiro P SP
Schneier Franklin R FR
Talati Ardesheer A
Roelofs Karin K
Volman Inge I
Blanco-Hinojo Laura L
Cardoner Narcís N
Pujol Jesus J
Beesdo-Baum Katja K
Ching Christopher R K CRK
Thomopoulos Sophia I SI
Jansen Andreas A
Kircher Tilo T
Krug Axel A
Nenadić Igor I
Stein Frederike F
Dannlowski Udo U
Grotegerd Dominik D
Lemke Hannah H
Meinert Susanne S
Winter Alexandra A
Erb Michael M
Kreifelts Benjamin B
Gong Qiyong Q
Lui Su S
Zhu Fei F
Mwangi Benson B
Soares Jair C JC
Wu Mon-Ju MJ
Bayram Ali A
Canli Mesut M
Tükel Raşit R
Westenberg P Michiel PM
Heeren Alexandre A
Cremers Henk R HR
Hofmann David D
Straube Thomas T
Doruyter Alexander G G AGG
Lochner Christine C
Peterburs Jutta J
Van Tol Marie-José MJ
Gur Raquel E RE
Kaczkurkin Antonia N AN
Larsen Bart B
Satterthwaite Theodore D TD
Filippi Courtney A CA
Gold Andrea L AL
Harrewijn Anita A
Zugman André A
Bülow Robin R
Grabe Hans J HJ
Völzke Henry H
Wittfeld Katharina K
Böhnlein Joscha J
Dohm Katharina K
Kugel Harald H
Schrammen Elisabeth E
Zwanzger Peter P
Leehr Elisabeth J EJ
Sindermann Lisa L
Ball Tali M TM
Fonzo Gregory A GA
Paulus Martin P MP
Simmons Alan A
Stein Murray B MB
Klumpp Heide H
Phan K Luan KL
Furmark Tomas T
Månsson Kristoffer N T KNT
Manzouri Amirhossein A
Avery Suzanne N SN
Blackford Jennifer Urbano JU
Clauss Jacqueline A JA
Feola Brandee B
Harper Jennifer C JC
Sylvester Chad M CM
Lueken Ulrike U
Veltman Dick J DJ
Winkler Anderson M AM
Jahanshad Neda N
Pine Daniel S DS
Thompson Paul M PM
Stein Dan J DJ
Van der Wee Nic J A NJA
Study Outcome
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