Outcome measures for Alzheimer's disease: A global inter-societal Delphi consensus.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association

Volume: 19

Issue: 6

Year of Publication: 2023

Affiliated Institutions:  PharmaGenesis London, London, UK. Scuola Universitaria Superiore IUSS Pavia, Pavia, Italy. Royal College of Nursing, London, UK. Alzheimer Europe, Luxembourg, Luxembourg. Unit for Early and Exploratory Clinical Development, The University of Tokyo Hospital, Tokyo, Japan. Department of Neurology, Memory and Aging Center, University of California, San Francisco, California, USA. World Dementia Council, George, South Africa. Richman Family Precision Medicine Center of Excellence in Alzheimer's Disease, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University and Medicine, Baltimore, USA. Department of Medicine and Aged Care, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, Victoria, Australia. Department of Neurology, Washington University, St. Louis, Missouri, USA. School of Psychology, The University of Sydney, Sydney, New South Wales, Australia. UO Clinica Neurologica, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Policlinico San Martino, Genova, Italy. Department of Aging and Geriatric Research, Institute on Aging, University of Florida College of Medicine, Gainesville, Florida, USA. Faculty of Health and Medicine, School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia. Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK. Department of Geriatric Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey. Neuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium. Alzheimer's Association, Chicago, Illinois, USA. Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, Netherlands. San Francisco Veterans Affairs Medical Center, San Francisco, California, USA. Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland.

Abstract summary 

We aim to provide guidance on outcomes and measures for use in patients with Alzheimer's clinical syndrome.A consensus group of 20 voting members nominated by 10 professional societies, and a non-voting chair, used a Delphi approach and modified GRADE criteria.Consensus was reached on priority outcomes (n = 66), measures (n = 49) and statements (n = 37) across nine domains. A number of outcomes and measurement instruments were ranked for: Cognitive abilities; Functional abilities/dependency; Behavioural and neuropsychiatric symptoms; Patient quality of life (QoL); Caregiver QoL; Healthcare and treatment-related outcomes; Medical investigations; Disease-related life events; and Global outcomes.This work provides indications on the domains and ideal pertinent measurement instruments that clinicians may wish to use to follow patients with cognitive impairment. More work is needed to develop instruments that are more feasible in the context of the constraints of clinical routine.

Authors & Co-authors:  Ellison Tim S TS Cappa Stefano F SF Garrett Dawne D Georges Jean J Iwatsubo Takeshi T Kramer Joel H JH Lehmann Maryna M Lyketsos Constantine C Maier Andrea B AB Merrilees Jennifer J Morris John C JC Naismith Sharon L SL Nobili Flavio F Pahor Marco M Pond Dimity D Robinson Louise L Soysal Pinar P Vandenbulcke Mathieu M Weber Christopher J CJ Visser Pieter Jelle PJ Weiner Michael M Frisoni Giovanni B GB

Study Outcome 

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Statistics
Citations :  Collaborators GBDDF. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019. Lancet Public Health. 2022;7:e105-e125.
Authors :  22
Identifiers
Doi : 10.1002/alz.12945
SSN : 1552-5279
Study Population
Male,Female
Mesh Terms
Humans
Other Terms
Alzheimer's disease;Delphi;consensus;dementia;measures;outcomes
Study Design
Cross Sectional Study
Study Approach
Country of Study
Publication Country
United States