Genetic Influences on the Developing Young Brain and Risk for Neuropsychiatric Disorders.

Journal: Biological psychiatry

Volume: 93

Issue: 10

Year of Publication: 2023

Affiliated Institutions:  Institute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, Michigan. Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Medical Psychology, Berlin, Germany; Department of Pediatrics, University of California Irvine, Irvine, California; Development, Health and Disease Research Program, University of California Irvine, Irvine, California. Department of Pediatrics, University of California Irvine, Irvine, California; Department of Psychology, University of Denver, Denver, Colorado. Institute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, Michigan; Departments of Epidemiology & Biostatistics, Michigan State University, East Lansing, Michigan; Department of Statistics & Probability, Michigan State University, East Lansing, Michigan. Division of Developmental Paediatrics, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa; Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Masonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, Minnesota; Institute of Child Development, College of Education and Human Development, University of Minnesota, Minneapolis, Minnesota; Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota. Harvard Graduate School of Education, Harvard University, Cambridge, Massachusetts. Cedars-Sinai Biomedical Imaging Research Institute, Los Angeles, California; Departments of Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, California. Department of Psychiatry, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina. Department of Psychiatry, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina; Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Carrboro, North Carolina. Neuroscience Institute, University of Cape Town, Cape Town, South Africa; South African Medical Research Council Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa; Department of Paediatrics and Child Health, University of Cape Town, Faculty of Health Sciences, Cape Town, South Africa. Psychology Department, University of Illinois Urbana,-Champaign, Illinois. Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Research Group Learning in Early Childhood, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. Department of Psychology, University of Denver, Denver, Colorado. Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California; Department of Psychology, University of Southern California, Los Angeles, California; Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, California. Roxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois; Department of Medical Social Sciences and Institute for Innovations in Developmental Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Departments of Psychiatry, Psychology, Neuroscience, Obstetrics and Gynecology, University of Rochester, Rochester, New York. Department of Biomedical Engineering, National University of Singapore, Singapore; NUS (Suzhou) Research Institute, National University of Singapore, China; the Institute for Health, National University of Singapore, Singapore; School of Computer Engineering and Science, Shanghai University, Shanghai, China; Institute of Data Science, National University of Singapore, Singapore; Department of Biomedical Engineering, the Johns Hopkins University, Baltimore, Maryland. Department of Pediatrics, University of California Irvine, Irvine, California; Development, Health and Disease Research Program, University of California Irvine, Irvine, California. Department of Psychiatry, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina; Research Group Learning in Early Childhood, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. South African Medical Research Council Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, University of Cape Town, Cape Town, South Africa; Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of the Sunshine Coast, Marina del Rey, California. Department of Medical Social Sciences and Institute for Innovations in Developmental Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Institute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, Michigan; Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan. Electronic address: knickmey@msu.edu.

Abstract summary 

Imaging genetics provides an opportunity to discern associations between genetic variants and brain imaging phenotypes. Historically, the field has focused on adults and adolescents; very few imaging genetics studies have focused on brain development in infancy and early childhood (from birth to age 6 years). This is an important knowledge gap because developmental changes in the brain during the prenatal and early postnatal period are regulated by dynamic gene expression patterns that likely play an important role in establishing an individual's risk for later psychiatric illness and neurodevelopmental disabilities. In this review, we summarize findings from imaging genetics studies spanning from early infancy to early childhood, with a focus on studies examining genetic risk for neuropsychiatric disorders. We also introduce the Organization for Imaging Genomics in Infancy (ORIGINs), a working group of the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) consortium, which was established to facilitate large-scale imaging genetics studies in infancy and early childhood.

Authors & Co-authors:  Alex Ann M AM Buss Claudia C Davis Elysia Poggi EP Campos Gustavo de Los GL Donald Kirsten A KA Fair Damien A DA Gaab Nadine N Gao Wei W Gilmore John H JH Girault Jessica B JB Grewen Karen K Groenewold Nynke A NA Hankin Benjamin L BL Ipser Jonathan J Kapoor Shreya S Kim Pilyoung P Lin Weili W Luo Shan S Norton Elizabeth S ES O'Connor Thomas G TG Piven Joseph J Qiu Anqi A Rasmussen Jerod M JM Skeide Michael A MA Stein Dan J DJ Styner Martin A MA Thompson Paul M PM Wakschlag Laurie L Knickmeyer Rebecca R

Study Outcome 

Source Link: Visit source

Statistics
Citations :  Strike L.T., Couvy-Duchesne B., Hansell N.K., Cuellar-Partida G., Medland S.E., Wright M.J. Genetics and brain morphology. Neuropsychol Rev. 2015;25:63–96.
Authors :  30
Identifiers
Doi : 10.1016/j.biopsych.2023.01.013
SSN : 1873-2402
Study Population
Female
Mesh Terms
Female
Other Terms
Childhood;Genetics;Imaging;Infant;Magnetic resonance imaging;Pediatric
Study Design
Cross Sectional Study
Study Approach
Country of Study
Publication Country
United States