The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium.
Journal: Molecular psychiatry
Volume: 28
Issue: 10
Year of Publication: 2024
Affiliated Institutions:
Amsterdam UMC location University of Amsterdam, Department of Psychiatry, Meibergdreef , Amsterdam, The Netherlands. willembenjamin@gmail.com.
Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain.
Department of Psychiatry, Yale University, New Haven, CT, USA.
Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Department of Psychiatry, National Institute of Mental Health And Neurosciences (NIMHANS), Bangalore, India.
CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain.
Department of Psychiatry, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
Vita-Salute San Raffaele University, Milano, Italy.
Bellvitge Biomedical Research Insitute-IDIBELL, Bellvitge University Hospital, Barcelona, Spain.
Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland.
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Amsterdam UMC location University of Amsterdam, Department of Psychiatry, Meibergdreef , Amsterdam, The Netherlands.
Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, USA.
Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
University of California, San Diego, CA, USA.
Molde Hospital, Møre og Romsdal Hospital Trust, Molde, Norway.
Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway.
Research Center for Child Mental Development, Chiba University, Chiba, Japan.
Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.
Amsterdam UMC, location Vrije Universiteit Amsterdam, Department of Psychiatry, De Boelelaan , Amsterdam, The Netherlands.
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Department of Neuroradiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea.
SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Graduate School of Medical Sciences, Kyushu University, Fukuoka-shi, Japan.
National Institute of Mental Health And Neurosciences (NIMHANS), Bangalore, India.
Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, CA, USA.
Magnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Division of Child and Adolescent Psychiatry, UCLA Semel Institute for Neuroscience, Los Angeles, CA, USA.
Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany.
Department of Integrative Medicine, National Institute of Mental Health And Neurosciences (NIMHANS), Bangalore, India.
Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.
ICVS/B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Department of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
Psychiatry & Clinical Psychobiology, Division of Neuroscience, IRCCS Scientific Institute Ospedale San Raffaele, Milano, Italy.
Department of Developmental Psychology, University of Amsterdam, Amsterdam, The Netherlands.
Department of Psychiatry and Neurosciences CCM, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao, China.
Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
Amsterdam UMC, location Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences, De Boelelaan , Amsterdam, The Netherlands.
SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Amsterdam UMC location University of Amsterdam, Department of Psychiatry, Meibergdreef , Amsterdam, The Netherlands. g.a.vanwingen@amsterdamumc.nl.
Abstract summary
Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. Moreover, the majority of studies have focused only on predefined regions or functional networks rather than connectivity throughout the entire brain. Here, we investigated differences in resting-state functional connectivity between OCD patients and healthy controls (HC) using mega-analysis of data from 1024 OCD patients and 1028 HC from 28 independent samples of the ENIGMA-OCD consortium. We assessed group differences in whole-brain functional connectivity at both the regional and network level, and investigated whether functional connectivity could serve as biomarker to identify patient status at the individual level using machine learning analysis. The mega-analyses revealed widespread abnormalities in functional connectivity in OCD, with global hypo-connectivity (Cohen's d: -0.27 to -0.13) and few hyper-connections, mainly with the thalamus (Cohen's d: 0.19 to 0.22). Most hypo-connections were located within the sensorimotor network and no fronto-striatal abnormalities were found. Overall, classification performances were poor, with area-under-the-receiver-operating-characteristic curve (AUC) scores ranging between 0.567 and 0.673, with better classification for medicated (AUC = 0.702) than unmedicated (AUC = 0.608) patients versus healthy controls. These findings provide partial support for existing pathophysiological models of OCD and highlight the important role of the sensorimotor network in OCD. However, resting-state connectivity does not so far provide an accurate biomarker for identifying patients at the individual level.
Authors & Co-authors:
Bruin Willem B WB
Abe Yoshinari Y
Alonso Pino P
Anticevic Alan A
Backhausen Lea L LL
Balachander Srinivas S
Bargallo Nuria N
Batistuzzo Marcelo C MC
Benedetti Francesco F
Bertolin Triquell Sara S
Brem Silvia S
Calesella Federico F
Couto Beatriz B
Denys Damiaan A J P DAJP
Echevarria Marco A N MAN
Eng Goi Khia GK
Ferreira Sónia S
Feusner Jamie D JD
Grazioplene Rachael G RG
Gruner Patricia P
Guo Joyce Y JY
Hagen Kristen K
Hansen Bjarne B
Hirano Yoshiyuki Y
Hoexter Marcelo Q MQ
Jahanshad Neda N
Jaspers-Fayer Fern F
Kasprzak Selina S
Kim Minah M
Koch Kathrin K
Bin Kwak Yoo Y
Kwon Jun Soo JS
Lazaro Luisa L
Li Chiang-Shan R CR
Lochner Christine C
Marsh Rachel R
Martínez-Zalacaín Ignacio I
Menchon Jose M JM
Moreira Pedro S PS
Morgado Pedro P
Nakagawa Akiko A
Nakao Tomohiro T
Narayanaswamy Janardhanan C JC
Nurmi Erika L EL
Zorrilla Jose C Pariente JCP
Piacentini John J
Picó-Pérez Maria M
Piras Fabrizio F
Piras Federica F
Pittenger Christopher C
Reddy Janardhan Y C JYC
Rodriguez-Manrique Daniela D
Sakai Yuki Y
Shimizu Eiji E
Shivakumar Venkataram V
Simpson Blair H BH
Soriano-Mas Carles C
Sousa Nuno N
Spalletta Gianfranco G
Stern Emily R ER
Evelyn Stewart S S
Szeszko Philip R PR
Tang Jinsong J
Thomopoulos Sophia I SI
Thorsen Anders L AL
Yoshida Tokiko T
Tomiyama Hirofumi H
Vai Benedetta B
Veer Ilya M IM
Venkatasubramanian Ganesan G
Vetter Nora C NC
Vriend Chris C
Walitza Susanne S
Waller Lea L
Wang Zhen Z
Watanabe Anri A
Wolff Nicole N
Yun Je-Yeon JY
Zhao Qing Q
van Leeuwen Wieke A WA
van Marle Hein J F HJF
van de Mortel Laurens A LA
van der Straten Anouk A
van der Werf Ysbrand D YD
Thompson Paul M PM
Stein Dan J DJ
van den Heuvel Odile A OA
van Wingen Guido A GA
Study Outcome
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