Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson's disease.
Journal: NPJ Parkinson's disease
Volume: 9
Issue: 1
Year of Publication:
Affiliated Institutions:
Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.
Norman Fixel Institute for Neurological Diseases, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Research Institute of Disease of Old Age, Graduate School of Medicine, Juntendo University, -- Hongo, Bunkyo-ku, Tokyo, -, Japan.
Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Griffith Institute of Drug Discovery (GRIDD), Griffith University, Brisbane, QLD, Australia.
First Department of Neurology and International Clinical Research Center, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Institute of Global Health and Human Ecology (I-GHHE), The American University in Cairo (AUC), New Cairo, , Egypt.
Departamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Pacific Parkinson's Research Centre, Department of Medicine (Division of Neurology), Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Neuroscience Research Australia; Faculty of Medicine, University of New South Wales; Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst; Department of Neurology, Prince of Wales Hospital, South Eastern Sydney Local Health District, Randwick, NSW, Australia.
Instituto de Neurociencia Biomédica (BNI), Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Institute of Neurogenetics, University of Lübeck and University Hospital Schleswig-Holstein, Lübeck, Germany. christine.klein@neuro.uni-luebeck.de.
Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. sbardien@sun.ac.za.
Abstract summary
The biological basis of the neurodegenerative movement disorder, Parkinson's disease (PD), is still unclear despite it being 'discovered' over 200 years ago in Western Medicine. Based on current PD knowledge, there are widely varying theories as to its pathobiology. The aim of this article was to explore some of these different theories by summarizing the viewpoints of laboratory and clinician scientists in the PD field, on the biological basis of the disease. To achieve this aim, we posed this question to thirteen "PD experts" from six continents (for global representation) and collated their personal opinions into this article. The views were varied, ranging from toxin exposure as a PD trigger, to LRRK2 as a potential root cause, to toxic alpha-synuclein being the most important etiological contributor. Notably, there was also growing recognition that the definition of PD as a single disease should be reconsidered, perhaps each with its own unique pathobiology and treatment regimen.
Authors & Co-authors:
Müller-Nedebock Amica C AC
Dekker Marieke C J MCJ
Farrer Matthew J MJ
Hattori Nobutaka N
Lim Shen-Yang SY
Mellick George D GD
Rektorová Irena I
Salama Mohamed M
Schuh Artur F S AFS
Stoessl A Jon AJ
Sue Carolyn M CM
Tan Ai Huey AH
Vidal Rene L RL
Klein Christine C
Bardien Soraya S
Study Outcome
Source Link: Visit source