European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.

Journal: Nature communications

Volume: 14

Issue: 1

Year of Publication: 2023

Affiliated Institutions:  Medical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, England. Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany. andMe, Inc., Sunnyvale, CA, USA. Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, , Norway. Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, La Laguna, Tenerife, Spain. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, København, Denmark. Max-Delbrück-Center for Molecular Medicine, Berlin, Germany. Swiss Tropical and Public Health Institute, CH-, Basel, Switzerland. Department of Health Sciences, University of Leicester, Leicester, LE RH, UK. Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany. Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany. School of Biosciences and Medicine, University of Surrey, Guildford, UK. Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Solna, Sweden. Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, , USA. The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. University of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergy, Beatrix Children's Hospital, Groningen, The Netherlands. MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK. Faculty of Medicine, University of Southampton, Southampton, UK. Department of Bioinformatics & Data Mining, Måløv, Denmark. School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia. Center for Individualized and Genomic Medicine Research (CIGMA), Department of Medicine, Henry Ford Health, Detroit, MI, , USA. Environmental Epidemiology of Lung, Brain and Skin Aging, IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany. Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK. Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA. Division of Immunology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. Institute for Human Genetics, UCSF, San Francisco, CA, , USA. Regeneron Genetics Center, Tarrytown, NY, USA. Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA. Center for Diabetes Research, Department of Clinical Science, University of Bergen, NO-, Bergen, Norway. NORMENT Centre, Institute of Clinical Medicine, University of Oslo, , Oslo, Norway. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark. Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark. Clinic and Polyclinic of Dermatology, University Medicine Greifswald, Greifswald, Germany. Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. Department of Pediatric Respiratory Medicine, Immunology, and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany. Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany. Department of Twin Research & Genetics Epidemiology, Kings College London, London, UK. Dept Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, the Netherlands. Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany. COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. Nursing School, University of Valencia, FISABIO-University Jaume I-University of Valencia, Valencia, Spain. ISGlobal, Institute for Global Health, Barcelona, Spain. Channing Division of Network Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA. Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. Department of Dermatology, University of California San Francisco, San Francisco, CA, USA. Population Health Research Institute, St George's, University of London, Cranmer Terrace, London, SW RE, UK. Department of Dermatology, Allergology and Venereology, University Hospital Schleswig-Holstein, Kiel, Germany. Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health,Imperial College London, London, UK. Department of Clinical Medicine, Trinity College, Dublin, Ireland. Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College London, London, United Kingdom. Department of Dermatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. Department of Pediatrics, division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands. MRC Lifecourse Epidemiology Centre and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. Children's Health and Environment Program, Child Health Research Centre, The University of Queensland, South Brisbane, , Queensland, Australia. Telethon Kids Institute, University of Western Australia, Perth, WA, Australia. Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Manchester, England. Environmental Epidemiology of Lung, Brain and Skin Aging, Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany. Division of Allergy and Immunology, Department of Pediatrics, and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Centre for Genomics and Experimental Medicine, Institute for Genetics and Cancer, University of Edinburgh, Crewe Road, Edinburgh, UK EH XU, Scotland. Medical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, England. l.paternoster@bristol.ac.uk.

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