Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium.
Journal: NeuroImage
Volume: 283
Issue:
Year of Publication: 2023
Affiliated Institutions:
Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA.
New York State Psychiatric Institute, New York, NY, USA.
Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.
University of Rochester, Rochester, NY, USA.
University of Haifa, Haifa, Israel.
Tel-Aviv University, Tel Aviv, Israel.
Baylor College of Medicine, Houston, TX, USA; Yale University School of Medicine, New Haven, CT, USA.
University of Michigan, Ann Arbor, MI, USA.
Duke University, Durham, NC, USA.
Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.
Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA.
University of California San Diego, La Jolla, CA, USA.
Center for Trauma Recovery, Department of Psychological Sciences, University of Missouri-St. Louis, St. Louis, MO, USA.
School of Psychology, University of New South Wales, Sydney, NSW, Australia.
Department of Radiology, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China.
Department of Psychiatry, University of Texas at Austin, Austin, TX, USA.
University of Toledo, Toledo, OH, USA.
University of Groningen, Groningen, The Netherlands.
Minneapolis VA Health Care System, Minneapolis, MN, USA.
University of Wisconsin-Madison, Madison, WI, USA.
University of Utah School of Medicine, Salt Lake City, UT, USA.
Departments of Psychology and Psychiatry, Neuroscience Program, Western University, London, ON, Canada; Department of Psychology, University of British Columbia, Okanagan, Kelowna, British Columbia, Canada.
Medical College of Wisconsin, Milwaukee, WI, USA.
UMR , CIC , University of Tours, CHRU de Tours, INSERM, France.
Stanford University, Stanford, CA, USA.
Emory University Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA.
Civil Aerospace Medical Institute, US Federal Aviation Administration, Oklahoma City, OK, USA.
Marquette University, Milwaukee, WI, USA.
Brain Health Research Centre, Department of Anatomy, University of Otago, Dunedin, New Zealand.
Department of Psychiatry, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Brain Research and Innovation Centre, Ministry of Defence, Utrecht, The Netherlands.
Cognitive and Clinical Neuroimaging Core, McLean Hospital, Belmont, MA, USA.
Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Division of Neuroradiology, Brigham and Women's Hospital, Boston, MA, USA.
School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Heidelberg University, Heidelberg, Germany.
University of Münster, Münster, Germany.
University of Illinois at Chicago, Chicago, IL, USA.
Ghent University, Ghent, Belgium.
University of Cape Town, Cape Town, South Africa.
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, CA, USA.
Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA.
Wayne State University School of Medicine, Detroit, MI, USA.
Division of Women's Mental Health, McLean Hospital, Belmont, MA, USA.
Department of Child and Adolescent Psychiatry, Psychosomatic and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany; Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.
Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, The Netherlands.
Westmead Institute for Medical Research, Westmead, NSW, Australia.
Yale University School of Medicine, New Haven, CT, USA.
Department of Neuroscience, Western University, London, ON, Canada.
University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
McLean Hospital, Belmont, MA, USA; Harvard Medical School, Boston, MA, USA.
Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Psychiatry and Behavioral Science, Texas A&M University Health Science Center, College Station, TX, USA.
Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
University of Iowa, Iowa City, IA, USA.
Charité Universitätsmedizin Berlin Campus Charite Mitte: Charite Universitatsmedizin Berlin, Berlin, Germany.
VISN Center of Excellence for Research on Returning War Veterans, Waco, TX, USA.
Harvard University, Boston, MA, USA.
Department of Psychiatry, Amsterdam University Medical Centers, VU University Medical Center, VU University, Amsterdam, The Netherlands.
Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Department of Psychology, Vanderbilt University, Nashville, TN, USA.
University of Washington, Seattle, WA, USA.
Department of Psychiatry and Behavioral Health, Ohio State University, Columbus, OH, USA.
School of Psychology, University of New South Wales, Sydney, NSW, Australia; Neuroscience Research Australia, Randwick, NSW, Australia.
Masaryk University, Brno, Czechia.
Northwestern Neighborhood and Networks Initiative, Northwestern University Institute for Policy Research, Evanston, IL, USA.
Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.
University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, USA.
University of South Dakota, Vermillion, SD, USA.
Minneapolis VA Health Care System, Minneapolis, MN, USA; University of Minnesota, Minneapolis, MN, USA.
Leiden University Medical Center, Leiden, The Netherlands.
University of California, Irvine, Irvine, CA, USA.
Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Abstract summary
Recent advances in data-driven computational approaches have been helpful in devising tools to objectively diagnose psychiatric disorders. However, current machine learning studies limited to small homogeneous samples, different methodologies, and different imaging collection protocols, limit the ability to directly compare and generalize their results. Here we aimed to classify individuals with PTSD versus controls and assess the generalizability using a large heterogeneous brain datasets from the ENIGMA-PGC PTSD Working group.We analyzed brain MRI data from 3,477 structural-MRI; 2,495 resting state-fMRI; and 1,952 diffusion-MRI. First, we identified the brain features that best distinguish individuals with PTSD from controls using traditional machine learning methods. Second, we assessed the utility of the denoising variational autoencoder (DVAE) and evaluated its classification performance. Third, we assessed the generalizability and reproducibility of both models using leave-one-site-out cross-validation procedure for each modality.We found lower performance in classifying PTSD vs. controls with data from over 20 sites (60 % test AUC for s-MRI, 59 % for rs-fMRI and 56 % for d-MRI), as compared to other studies run on single-site data. The performance increased when classifying PTSD from HC without trauma history in each modality (75 % AUC). The classification performance remained intact when applying the DVAE framework, which reduced the number of features. Finally, we found that the DVAE framework achieved better generalization to unseen datasets compared with the traditional machine learning frameworks, albeit performance was slightly above chance.These results have the potential to provide a baseline classification performance for PTSD when using large scale neuroimaging datasets. Our findings show that the control group used can heavily affect classification performance. The DVAE framework provided better generalizability for the multi-site data. This may be more significant in clinical practice since the neuroimaging-based diagnostic DVAE classification models are much less site-specific, rendering them more generalizable.
Authors & Co-authors:
Zhu Xi X
Kim Yoojean Y
Ravid Orren O
He Xiaofu X
Suarez-Jimenez Benjamin B
Zilcha-Mano Sigal S
Lazarov Amit A
Lee Seonjoo S
Abdallah Chadi G CG
Angstadt Michael M
Averill Christopher L CL
Baird C Lexi CL
Baugh Lee A LA
Blackford Jennifer U JU
Bomyea Jessica J
Bruce Steven E SE
Bryant Richard A RA
Cao Zhihong Z
Choi Kyle K
Cisler Josh J
Cotton Andrew S AS
Daniels Judith K JK
Davenport Nicholas D ND
Davidson Richard J RJ
DeBellis Michael D MD
Dennis Emily L EL
Densmore Maria M
deRoon-Cassini Terri T
Disner Seth G SG
Hage Wissam El WE
Etkin Amit A
Fani Negar N
Fercho Kelene A KA
Fitzgerald Jacklynn J
Forster Gina L GL
Frijling Jessie L JL
Geuze Elbert E
Gonenc Atilla A
Gordon Evan M EM
Gruber Staci S
Grupe Daniel W DW
Guenette Jeffrey P JP
Haswell Courtney C CC
Herringa Ryan J RJ
Herzog Julia J
Hofmann David Bernd DB
Hosseini Bobak B
Hudson Anna R AR
Huggins Ashley A AA
Ipser Jonathan C JC
Jahanshad Neda N
Jia-Richards Meilin M
Jovanovic Tanja T
Kaufman Milissa L ML
Kennis Mitzy M
King Anthony A
Kinzel Philipp P
Koch Saskia B J SBJ
Koerte Inga K IK
Koopowitz Sheri M SM
Korgaonkar Mayuresh S MS
Krystal John H JH
Lanius Ruth R
Larson Christine L CL
Lebois Lauren A M LAM
Li Gen G
Liberzon Israel I
Lu Guang Ming GM
Luo Yifeng Y
Magnotta Vincent A VA
Manthey Antje A
Maron-Katz Adi A
May Geoffery G
McLaughlin Katie K
Mueller Sven C SC
Nawijn Laura L
Nelson Steven M SM
Neufeld Richard W J RWJ
Nitschke Jack B JB
O'Leary Erin M EM
Olatunji Bunmi O BO
Olff Miranda M
Peverill Matthew M
Phan K Luan KL
Qi Rongfeng R
Quidé Yann Y
Rektor Ivan I
Ressler Kerry K
Riha Pavel P
Ross Marisa M
Rosso Isabelle M IM
Salminen Lauren E LE
Sambrook Kelly K
Schmahl Christian C
Shenton Martha E ME
Sheridan Margaret M
Shih Chiahao C
Sicorello Maurizio M
Sierk Anika A
Simmons Alan N AN
Simons Raluca M RM
Simons Jeffrey S JS
Sponheim Scott R SR
Stein Murray B MB
Stein Dan J DJ
Stevens Jennifer S JS
Straube Thomas T
Sun Delin D
Théberge Jean J
Thompson Paul M PM
Thomopoulos Sophia I SI
van der Wee Nic J A NJA
van der Werff Steven J A SJA
van Erp Theo G M TGM
van Rooij Sanne J H SJH
van Zuiden Mirjam M
Varkevisser Tim T
Veltman Dick J DJ
Vermeiren Robert R J M RRJM
Walter Henrik H
Wang Li L
Wang Xin X
Weis Carissa C
Winternitz Sherry S
Xie Hong H
Zhu Ye Y
Wall Melanie M
Neria Yuval Y
Morey Rajendra A RA
Study Outcome
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