Cerebellar Volume and Disease Staging in Parkinson's Disease: An ENIGMA-PD Study.

Journal: Movement disorders : official journal of the Movement Disorder Society

Volume: 38

Issue: 12

Year of Publication: 2023

Affiliated Institutions:  Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia. Department Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA. Monash Bioinformatics Platform, Monash University, Melbourne, Victoria, Australia. Faculty of Health and Medicine, The University of Lancaster, Lancaster, United Kingdom. New Zealand Brain Research Institute, Christchurch, New Zealand. Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy. Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil. Department Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. Department of Neurology and Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands. School of Physics and Astronomy, Faculty of Science and Engineering, The University of Manchester, Manchester, United Kingdom. Division of Neurology, Tygerberg Hospital and Stellenbosch University, Cape Town, South Africa. Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. Department of Neurology and Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA. Lancaster Medical School, Lancaster University, Lancaster, United Kingdom. GIGA-CRC in vivo imaging, University of Liège, Liège, Belgium. Division of Psychology, Communication and Human Neuroscience, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom. Department of Neurology and Neurosurgery, National Institute of Health, Yerevan, Armenia. Department of Psychiatry, SA MRC Unit on Risk and Resilience in Mental Disorders, Stellenbosch University, Cape Town, South Africa. Clinical Brain Networks Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria. Division of Psychology, Communication and Human Neuroscience, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom. Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA. Excellence Center for Advanced MR Techniques and Parkinson's Disease Center, Neurology unit, Fondazione IRCCS Cà Granda Maggiore Policlinico Hospital, University of Milan, Milan, Italy. Department of Psychiatry and Neuroscience Institute, SA MRC Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa. Support Center for Advanced Neuroimaging, (SCAN) University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Department of Neurology, Medical University of Graz, Graz, Austria. Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy. Healthy Aging Research Center, Chang Gung University, Taoyuan City, Taiwan.

Abstract summary 

Increasing evidence points to a pathophysiological role for the cerebellum in Parkinson's disease (PD). However, regional cerebellar changes associated with motor and non-motor functioning remain to be elucidated.To quantify cross-sectional regional cerebellar lobule volumes using three dimensional T1-weighted anatomical brain magnetic resonance imaging from the global ENIGMA-PD working group.Cerebellar parcellation was performed using a deep learning-based approach from 2487 people with PD and 1212 age and sex-matched controls across 22 sites. Linear mixed effects models compared total and regional cerebellar volume in people with PD at each Hoehn and Yahr (HY) disease stage, to an age- and sex- matched control group. Associations with motor symptom severity and Montreal Cognitive Assessment scores were investigated.Overall, people with PD had a regionally smaller posterior lobe (d  = -0.15). HY stage-specific analyses revealed a larger anterior lobule V bilaterally (d  = 0.28) in people with PD in HY stage 1 compared to controls. In contrast, smaller bilateral lobule VII volume in the posterior lobe was observed in HY stages 3, 4, and 5 (d  = -0.76), which was incrementally lower with higher disease stage. Within PD, cognitively impaired individuals had lower total cerebellar volume compared to cognitively normal individuals (d = -0.17).We provide evidence of a dissociation between anterior "motor" lobe and posterior "non-motor" lobe cerebellar regions in PD. Whereas less severe stages of the disease are associated with larger motor lobe regions, more severe stages of the disease are marked by smaller non-motor regions. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Authors & Co-authors:  Kerestes Rebecca R Laansma Max A MA Owens-Walton Conor C Perry Andrew A van Heese Eva M EM Al-Bachari Sarah S Anderson Tim J TJ Assogna Francesca F Aventurato Ítalo K ÍK van Balkom Tim D TD Berendse Henk W HW van den Berg Kevin R E KRE Betts Rebecca R Brioschi Ricardo R Carr Jonathan J Cendes Fernando F Clark Lyles R LR Dalrymple-Alford John C JC Dirkx Michiel F MF Druzgal Jason J Durrant Helena H Emsley Hedley C A HCA Garraux Gaëtan G Haroon Hamied A HA Helmich Rick C RC van den Heuvel Odile A OA João Rafael B RB Johansson Martin E ME Khachatryan Samson G SG Lochner Christine C McMillan Corey T CT Melzer Tracy R TR Mosley Philip E PE Newman Benjamin B Opriessnig Peter P Parkes Laura M LM Pellicano Clelia C Piras Fabrizio F Pitcher Toni L TL Poston Kathleen L KL Rango Mario M Roos Annerine A Rummel Christian C Schmidt Reinhold R Schwingenschuh Petra P Silva Lucas S LS Smith Viktorija V Squarcina Letizia L Stein Dan J DJ Tavadyan Zaruhi Z Tsai Chih-Chien CC Vecchio Daniela D Vriend Chris C Wang Jiun-Jie JJ Wiest Roland R Yasuda Clarissa L CL Young Christina B CB Jahanshad Neda N Thompson Paul M PM van der Werf Ysbrand D YD Harding Ian H IH

Study Outcome 

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Statistics
Citations :  Laansma MA, Bright JK, Al-Bachari S, et al. International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson’s Disease. Mov Disord. 2021;36(11):2583–2594.
Authors :  62
Identifiers
Doi : 10.1002/mds.29611
SSN : 1531-8257
Study Population
Male,Female
Mesh Terms
Humans
Other Terms
MRI;Parkinson's disease;cerebellum;disease staging
Study Design
Case Control Trial,Cross Sectional Study
Study Approach
Mixed Methods
Country of Study
Publication Country
United States