A global multicohort study to map subcortical brain development and cognition in infancy and early childhood.

Journal: Nature neuroscience

Volume: 27

Issue: 1

Year of Publication: 2024

Affiliated Institutions:  Institute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, MI, USA. Mallinickrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA. Department of Medical Psychology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Department of Radiology, University of Washington Medical Center, Seattle, WA, USA. Division of Developmental Paediatrics, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa. Masonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA. Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore. Harvard Graduate School of Education, Harvard University, Cambridge, MA, USA. Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA. Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Carboro, NC, USA. Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore. Department of Pediatrics, University of California Irvine, Irvine, CA, USA. Center for Autism Research, Children's Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, PA, USA. Research Group Learning in Early Childhood, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. Department of Psychiatry, University of Cape Town, Cape Town, South Africa. Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California, Marina del Rey, CA, USA. South African Medical Research Council (SA-MRC) Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa. A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Institute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, MI, USA. knickmey@msu.edu.

Abstract summary 

The human brain grows quickly during infancy and early childhood, but factors influencing brain maturation in this period remain poorly understood. To address this gap, we harmonized data from eight diverse cohorts, creating one of the largest pediatric neuroimaging datasets to date focused on birth to 6 years of age. We mapped the developmental trajectory of intracranial and subcortical volumes in ∼2,000 children and studied how sociodemographic factors and adverse birth outcomes influence brain structure and cognition. The amygdala was the first subcortical volume to mature, whereas the thalamus exhibited protracted development. Males had larger brain volumes than females, and children born preterm or with low birthweight showed catch-up growth with age. Socioeconomic factors exerted region- and time-specific effects. Regarding cognition, males scored lower than females; preterm birth affected all developmental areas tested, and socioeconomic factors affected visual reception and receptive language. Brain-cognition correlations revealed region-specific associations.

Authors & Co-authors:  Alex Ann M AM Aguate Fernando F Botteron Kelly K Buss Claudia C Chong Yap-Seng YS Dager Stephen R SR Donald Kirsten A KA Entringer Sonja S Fair Damien A DA Fortier Marielle V MV Gaab Nadine N Gilmore John H JH Girault Jessica B JB Graham Alice M AM Groenewold Nynke A NA Hazlett Heather H Lin Weili W Meaney Michael J MJ Piven Joseph J Qiu Anqi A Rasmussen Jerod M JM Roos Annerine A Schultz Robert T RT Skeide Michael A MA Stein Dan J DJ Styner Martin M Thompson Paul M PM Turesky Ted K TK Wadhwa Pathik D PD Zar Heather J HJ Zöllei Lilla L de Los Campos Gustavo G Knickmeyer Rebecca C RC

Study Outcome 

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Statistics
Citations :  Stiles, J. & Jernigan, T. L. The basics of brain development. Neuropsychol. Rev.20, 327–348 (2010).
Authors :  34
Identifiers
Doi : 10.1038/s41593-023-01501-6
SSN : 1546-1726
Study Population
Males,Male
Mesh Terms
Male
Other Terms
Study Design
Cohort Study,Cross Sectional Study
Study Approach
Country of Study
Publication Country
United States