Abstract summary 

Early detection of psychosis improves treatment outcomes, but there is limited research evaluating the validity of psychosis screening instruments, particularly in low-resourced countries.This study aims to assess the construct validity and psychometric properties of the psychosis screening questionnaire (PSQ) in South Africa.This study was conducted at several health centres in the Western and Eastern Cape provinces in South Africa.The sample consisted of 2591 South African adults participating as controls in a multi-country case-control study of psychiatric genetics. Using confirmatory factor analysis and item response theory, we evaluated the psychometric properties of the PSQ.Approximately 11% of the participants endorsed at least one psychotic experience on the PSQ, and almost half of them (49%) occurred within the last 12 months. A unidimensional model demonstrated good fit (root mean square error of approximation [RMSEA] = 0.023, comparative fit index [CFI] = 0.977 and Tucker-Lewis Index [TLI] = 0.954). The mania item had the weakest association with a single latent factor (standardised factor loading = 0.14). Model fit improved after removing the mania item (RMSEA = 0.025, CFI = 0.991 and TLI = 0.972). With item response theory analysis, the PSQ provided more information at higher latent trait levels.Consistent with prior literature, the PSQ demonstrated a unidimensional factor structure among South Africans. In our study, the PSQ in screening for psychosis performed better without the mania item, but future criterion validity studies are warranted.This study highlights that PSQ can be used to screen for early psychosis.

Authors & Co-authors:  Thungana Yanga Y Zingela Zukiswa Z van Wyk Stefan S Kim Hannah H HH Ametaj Amantia A Stevenson Anne A Stroud Rocky E RE Stein Dan J DJ Gelaye Bizu B

Study Outcome 

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