Normative Modeling of Brain Morphometry Across the Lifespan Using CentileBrain: Algorithm Benchmarking and Model Optimization.

Journal: bioRxiv : the preprint server for biology

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Affiliated Institutions:  Djavad Mowafagian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Center, King's College London, London, UK. Department of Psychiatry, Marqués de Valdecilla University Hospital, Valdecilla Biomedical Research Institute (IDIVAL), Santander, Spain. Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy. Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany. Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy. Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. Translational Psychiatry Unit, Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany. Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA. Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, Australia. Department of Psychiatry, UMC Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. Department of Psychology, Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA. Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands. Clinical Neuroimaging Laboratory, National University of Ireland Galway, Galway, Ireland. MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK. Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden. Department of Psychiatry and Addiction, Université de Montréal, CHU Ste Justine, Montréal, Canada. University Hospital Virgen del Rocio, Seville, Spain; Department of Psychiatry, University of Seville, Institute of Biomedicine of Seville (IBIS), Seville, Spain. Institut des Maladies Neurodégénératives, Université de Bordeaux, Bordeaux, France. Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, The Netherlands. Department of Psychiatry, Amsterdam UMC, Amsterdam, The Netherlands. School of Psychology & Counselling, Faculty of Health, Queensland University of Technology, Brisbane, Australia. Laboratory of Biological Psychiatry, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy. Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany. Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands. Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands. University Clinics and Clinics for Psychiatry, Psychotherapy and Psychosomatic Medicine, RWTH Aachen University, Aachen, Germany. Department of Psychiatry, Tommy Fuss Center for Neuropsychiatric Disease Research Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany. Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany. Department of Psychiatry, Yale University, New Haven, Connecticut, USA. Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, Australia. Center for Multimodal Imaging and Genetics, University of California San Diego, La jolla, California, USA. Brain and Mind Centre, University of Sydney, Sydney, Australia. Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Department of Child and Adolescent Psychiatry, Academic Medical Centre/De Bascule, Amsterdam, The Netherlands. Center for Human Development, Departments of Cognitive Science, Psychiatry, and Radiology, University of California, San Diego, USA. Department of Neuropsychiatry, University of Cape Town, Cape Town, South Africa. Department of Radiology, The Ohio State University College of Medicine, Columbus, Ohio, USA. Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands. Sunshine Coast Mind and Neuroscience - Thompson Institute, University of the Sunshine Coast, Queensland, Australia. Department of Child and Adolescent Psychiatry and Psychology, Hospital Clínic Barcelona, Barcelona, Spain. Mental Health Research Center, Moscow, Russia. SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa. Queensland Institute of Medical Research, Berghofer Medical Research Institute, Brisbane, Australia. Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA. Centre for Neuroimaging & Cognitive Genomics (NICOG), NCBES Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland. School of Clinical Sciences, Centre for Biomedical Technologies, Queensland University of Technology, Brisbane, Australia. Department of Neuropsychiatry, Kyushu University, Fukuoka, Japan. Department of Radiation Sciences, Umeå Center for Functional Brain Imaging, Umeå University, Umeå, Sweden; Department of Integrative Medical Biology, Umeå University, Umeå, Sweden. Mental Health Research Networking Center (CIBERSAM), Madrid, Spain. Key Laboratory of Cognition and Personality, Southwest University, Ministry of Education, Chongqing, PR China. Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology, and Neuroscience, Social, Genetic & Developmental Psychiatry Centre, King's College London, London, UK; Institute for Science and Technology of Brain-inspired Intelligence, Fudan University, Shanghai, PR China; Centre for Population Neuroscience and Stratified Medicine (PONS), Charite Mental Health, Department of Psychiatry and Psychotherapy, CCM, Charite Universitätsmedizin Berlin, Berlin, Germany. Institute of Mental Health, Singapore. Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. University of Texas Health Harris County Psychiatric Center, Houston, Texas, USA. Department of Biomedical Sciences of Cells and Systems, Rijksuniversiteit Groningen, University Medical Center Groningen, Groningen, The Netherlands. SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck USC School of Medicine, Marina del Rey, California, USA. Department of Radiology, Marqués de Valdecilla University Hospital, Valdecilla Biomedical Research Institute (IDIVAL), Santander, Spain; Advanced Computing and e-Science, Instituto de Física de Cantabria (UC-CSIC), Santander, Spain. Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands. Department of Psychiatry and Human Behavior, University of California, Irvine, California, USA. Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, The Netherlands. Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. Institute for Experimental Epileptology and Cognition Research, University of Bonn Germany, Bonn, Germany; University Hospital Bonn, Bonn, Germany. Department of Psychology, University of Oslo, Oslo, Norway. Institute of Psychology, Leiden University, Leiden, The Netherlands; Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands. Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. Department of Psychiatry and Behavioral Science, University of Texas Health Science Center, Houston, Texas, USA.

Abstract summary 

We present an empirically benchmarked framework for sex-specific normative modeling of brain morphometry that can inform about the biological and behavioral significance of deviations from typical age-related neuroanatomical changes and support future study designs. This framework was developed using regional morphometric data from 37,407 healthy individuals (53% female; aged 3-90 years) following a comparative evaluation of eight algorithms and multiple covariate combinations pertaining to image acquisition and quality, parcellation software versions, global neuroimaging measures, and longitudinal stability. The Multivariate Factorial Polynomial Regression (MFPR) emerged as the preferred algorithm optimized using nonlinear polynomials for age and linear effects of global measures as covariates. The MFPR models showed excellent accuracy across the lifespan and within distinct age-bins, and longitudinal stability over a 2-year period. The performance of all MFPR models plateaued at sample sizes exceeding 3,000 study participants. The model and scripts described here are freely available through CentileBrain (https://centilebrain.org/).

Authors & Co-authors:  Ge Ruiyang R Yu Yuetong Y Qi Yi Xuan YX Fan Yunan Vera YV Chen Shiyu S Gao Chuntong C Haas Shalaila S SS Modabbernia Amirhossein A New Faye F Agartz Ingrid I Asherson Philip P Ayesa-Arriola Rosa R Banaj Nerisa N Banaschewski Tobias T Baumeister Sarah S Bertolino Alessandro A Boomsma Dorret I DI Borgwardt Stefan S Bourque Josiane J Brandeis Daniel D Breier Alan A Brodaty Henry H Brouwer Rachel M RM Buckner Randy R Buitelaar Jan K JK Cannon Dara M DM Caseras Xavier X Cervenka Simon S Conrod Patricia J PJ Crespo-Facorro Benedicto B Crivello Fabrice F Crone Eveline A EA de Haan Liewe L de Zubicaray Greig I GI Di Giorgio Annabella A Erk Susanne S Fisher Simon E SE Franke Barbara B Frodl Thomas T Glahn David C DC Grotegerd Dominik D Gruber Oliver O Gruner Patricia P Gur Raquel E RE Gur Ruben C RC Harrison Ben J BJ Hatton Sean N SN Hickie Ian I Howells Fleur M FM Pol Hilleke E Hulshoff HEH Huyser Chaim C Jernigan Terry L TL Jiang Jiyang J Joska John A JA Kahn René S RS Kalnin Andrew J AJ Kochan Nicole A NA Koops Sanne S Kuntsi Jonna J Lagopoulos Jim J Lazaro Luisa L Lebedeva Irina S IS Lochner Christine C Martin Nicholas G NG Mazoyer Bernard B McDonald Brenna C BC McDonald Colm C McMahon Katie L KL Nakao Tomohiro T Nyberg Lars L Piras Fabrizio F Portella Maria J MJ Qiu Jiang J Roffman Joshua L JL Sachdev Perminder S PS Sanford Nicole N Satterthwaite Theodore D TD Saykin Andrew J AJ Schumann Gunter G Sellgren Carl M CM Sim Kang K Smoller Jordan W JW Soares Jair J Sommer Iris E IE Spalletta Gianfranco G Stein Dan J DJ Tamnes Christian K CK Thomopolous Sophia I SI Tomyshev Alexander S AS Tordesillas-Gutiérrez Diana D Trollor Julian N JN van 't Ent Dennis D van den Heuvel Odile A OA van Erp Theo Gm TG van Haren Neeltje Em NE Vecchio Daniela D Veltman Dick J DJ Walter Henrik H Wang Yang Y Weber Bernd B Wei Dongtao D Wen Wei W Westlye Lars T LT Wierenga Lara M LM Williams Steven Cr SC Wright Margaret J MJ Medland Sarah S Wu Mon-Ju MJ Yu Kevin K Jahanshad Neda N Thompson Paul M PM Frangou Sophia S

Study Outcome 

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Citations :  Bethlehem RAI, Seidlitz J, White SR, et al. Brain charts for the human lifespan. Nature 2022;604: 525–33.
Authors :  112
Identifiers
Doi : 2023.01.30.523509
SSN : 
Study Population
Male,Female
Mesh Terms
Other Terms
Study Design
Longitudinal Study,Cross Sectional Study
Study Approach
Country of Study
Publication Country
United States