Dropout from exercise trials among cancer survivors-An individual patient data meta-analysis from the POLARIS study.

Journal: Scandinavian journal of medicine & science in sports

Volume: 34

Issue: 2

Year of Publication: 2024

Affiliated Institutions:  Department of Sport Science and Physical Education, University of Agder, Kristiansand, Norway. Centre of Research on Welfare, Health and Sport, Halmstad University, Halmstad, Sweden. Department of Clinical Science, University of Bergen, Bergen, Norway. Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands. Lane Fox Respiratory Research Unit, Guy's and St Thomas' NHS Foundation Trust, London, UK. Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. Institute of Psychiatric and Psychosomatic Psychotherapy, Central Institute of Mental Health, Mannheim, Germany. Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Canada. Centre for Lifestyle Medicine and Behaviour (CLiMB), The School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. Exercise Medicine Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia. Department of Respiratory Medicine, King's College London, London, UK. Department of Psychology, University of Groningen, Groningen, Netherlands. The George Washington University, Washington, District of Columbia, USA. School of Public Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia. Fundación GIAFyS Cancer, Miranda de Ebro, Spain. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. Yale School of Public Health, New Haven, Connecticut, USA. School of Medicine & Public Health, The University of Newcastle, Callaghan, New South Wales, Australia. Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands. Department of Hematology, Amsterdam University Medical Centers, Cancer Center Amsterdam and LYMMCARE, Amsterdam, The Netherlands. Department of Medical Psychology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. European University, Madrid, Spain. School of Health and Wellbeing, University of Glasgow, Glasgow, UK. Department of Public and Occupational Health, Amsterdam University Medical Centers, Amsterdam, The Netherlands. Physical Activity for Health Research Center, University of Edinburgh, Edinburgh, UK. Department of Rehabilitation Medicine, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands. Priority Research Centre for Physical Activity and Nutrition, the University of Newcastle, Callaghan, New South Wales, Australia. Division of Physical Activity, Prevention and Cancer, German Cancer Research Center (DKFZ) and National Center for Tumor Disease (NCT), Heidelberg, Germany. University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Competence Center for Sports- and Exercise Medicine (Athleticum) and Institute for Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Melbourne Centre for Behaviour Change, Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia. National Advisory Unit on Late Effects after Cancer Treatment, Department of Oncology, Division of Cancer Medicine, Oslo University Hospital, Oslo, Norway. Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands. Johns Hopkins School of Nursing, Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA. Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA. Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and Heidelberg University Clinic, Heidelberg, Germany. Department of Physiology, Radboudumc, Nijmegen, The Netherlands.

Abstract summary 

The number of randomized controlled trials (RCTs) investigating the effects of exercise among cancer survivors has increased in recent years; however, participants dropping out of the trials are rarely described. The objective of the present study was to assess which combinations of participant and exercise program characteristics were associated with dropout from the exercise arms of RCTs among cancer survivors.This study used data collected in the Predicting OptimaL cAncer RehabIlitation and Supportive care (POLARIS) study, an international database of RCTs investigating the effects of exercise among cancer survivors. Thirty-four exercise trials, with a total of 2467 patients without metastatic disease randomized to an exercise arm were included. Harmonized studies included a pre and a posttest, and participants were classified as dropouts when missing all assessments at the post-intervention test. Subgroups were identified with a conditional inference tree.Overall, 9.6% of the participants dropped out. Five subgroups were identified in the conditional inference tree based on four significant associations with dropout. Most dropout was observed for participants with BMI >28.4 kg/m , performing supervised resistance or unsupervised mixed exercise (19.8% dropout) or had low-medium education and performed aerobic or supervised mixed exercise (13.5%). The lowest dropout was found for participants with BMI >28.4 kg/m and high education performing aerobic or supervised mixed exercise (5.1%), and participants with BMI ≤28.4 kg/m exercising during (5.2%) or post (9.5%) treatment.There are several systematic differences between cancer survivors completing and dropping out from exercise trials, possibly affecting the external validity of exercise effects.

Authors & Co-authors:  Western Benedikte B Ivarsson Andreas A Vistad Ingvild I Demmelmaier Ingrid I Aaronson Neil K NK Radcliffe Gillian G van Beurden Marc M Bohus Martin M Courneya Kerry S KS Daley Amanda J AJ Galvão Daniel A DA Garrod Rachel R Goedendorp Martine M MM Griffith Kathleen A KA van Harten Wim H WH Hayes Sandi C SC Herrero-Roman Fernando F Hiensch Anouk E AE Irwin Melinda L ML James Erica E Kenkhuis Marlou-Floor MF Kersten Marie José MJ Knoop Hans H Lucia Alejandro A May Anne M AM McConnachie Alex A van Mechelen Willem W Mutrie Nanette N Newton Robert U RU Nollet Frans F Oldenburg Hester S HS Plotnikoff Ron R Schmidt Martina E ME Schmitz Katie H KH Schulz Karl-Heinz KH Short Camille E CE Sonke Gabe S GS Steindorf Karen K Stuiver Martijn M MM Taaffe Dennis R DR Thorsen Lene L Velthuis Miranda J MJ Wenzel Jennifer J Winters-Stone Kerri M KM Wiskemann Joachim J Berntsen Sveinung S Buffart Laurien M LM

Study Outcome 

Source Link: Visit source

Statistics
Citations :  Campbell KL, Winters-Stone KM, Wiskemann J, et al. Exercise guidelines for cancer survivors: consensus statement from international multidisciplinary roundtable. Med Sci Sports Exerc. 2019;51(11):2375-2390.
Authors :  47
Identifiers
Doi : 10.1111/sms.14575
SSN : 1600-0838
Study Population
Male,Female
Mesh Terms
Humans
Other Terms
cancer;decision tree;exercise oncology;individual patient data meta-analysis
Study Design
Randomized Control Trial,Cross Sectional Study
Study Approach
Mixed Methods,Systemic Review
Country of Study
Publication Country
Denmark