STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease.

Journal: Alzheimer's & dementia (Amsterdam, Netherlands)

Volume: 7

Issue: 

Year of Publication: 

Affiliated Institutions:  Centre for Healthy Brain Ageing (CHeBA), University of New South Wales, Sydney, Australia; Dementia Collaborative Research Centre, University of New South Wales, Sydney, Australia. Centre for Healthy Brain Ageing (CHeBA), University of New South Wales, Sydney, Australia. Department of Psychology, Royal College of Surgeons in Ireland, Dublin, Ireland. Department of Stroke and Geriatric Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland. University of Lille, Inserm, CHU Lille, U - Degenerative & Vascular Cognitive Disorders, Lille, France. University of Lille, Inserm, CHU Lille, CIC - Centre d'investigation clinique, Lille, France. Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea; Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea. Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia. School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands. Centre for Healthy Brain Ageing (CHeBA), University of New South Wales, Sydney, Australia; Dementia Collaborative Research Centre, University of New South Wales, Sydney, Australia; Memory Ageing and Cognition Center, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Medicine (Neurology Division), Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Memory Ageing and Cognition Center, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Medicine (Neurology Division), Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Memory Ageing and Cognition Center, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Neurovascular Research Group, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK. Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training College of Medicine, University of Ibadan, Ibadan, Nigeria. Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training College of Medicine, University of Ibadan, Ibadan, Nigeria; Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria. Department of Neurology, Jagiellonian University Medical College, Krakow, Poland. Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University, Munich, Germany. Cognitive Neurology and Stroke Programs, University of Central Florida, Orlando VA Medical Center, Orlando, Florida, USA. No Affiliation. Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia; Institute of Neuroscience and Physiology, Centre of Brain Research and Rehabilitation, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Hunter Medical Research Institute, Newcastle, NSW, Australia. Institute of Neuroscience and Physiology, Centre of Brain Research and Rehabilitation, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Department of Molecular and Clinical Medicine, Wallenberg Laboratory for Cardiovascular and Metabolic Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Institute of Neuroscience and Physiology, Center for Health and Ageing AGECAP, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Department of Neurology and Laboratory of Functional Neurosciences, University Hospital of Amiens, France. Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK. Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia; Menzies Institute for Medical Research, University of Tasmania, Tasmania, Australia. Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea; Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia. Department of Neurology, National Neuroscience Institute, Singapore. Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, the Netherlands. Academic Section of Geriatrics, University of Glasgow, Glasgow, United Kingdom. Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands. Clinical Neurosciences, Neurology, University of Helsinki and Helsinki University Hospital, Finland. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; Therese Pei Fong Chow Research Centre for Prevention of Dementia, Hong Kong SAR, China.

Abstract summary 

The Stroke and Cognition consortium (STROKOG) aims to facilitate a better understanding of the determinants of vascular contributions to cognitive disorders and help improve the diagnosis and treatment of vascular cognitive disorders (VCD).Longitudinal studies with ≥75 participants who had suffered or were at risk of stroke or TIA and which evaluated cognitive function were invited to join STROKOG. The consortium will facilitate projects investigating rates and patterns of cognitive decline, risk factors for VCD, and biomarkers of vascular dementia.Currently, STROKOG includes 25 (21 published) studies, with 12,092 participants from five continents. The duration of follow-up ranges from 3 months to 21 years.Although data harmonization will be a key challenge, STROKOG is in a unique position to reuse and combine international cohort data and fully explore patient level characteristics and outcomes. STROKOG could potentially transform our understanding of VCD and have a worldwide impact on promoting better vascular cognitive outcomes.

Authors & Co-authors:  Sachdev Perminder S PS Lo Jessica W JW Crawford John D JD Mellon Lisa L Hickey Anne A Williams David D Bordet Régis R Mendyk Anne-Marie AM Gelé Patrick P Deplanque Dominique D Bae Hee-Joon HJ Lim Jae-Sung JS Brodtmann Amy A Werden Emilio E Cumming Toby T Köhler Sebastian S Verhey Frans R J FR Dong Yan-Hong YH Tan Hui Hui HH Chen Christopher C Xin Xu X Kalaria Raj N RN Allan Louise M LM Akinyemi Rufus O RO Ogunniyi Adesola A Klimkowicz-Mrowiec Aleksandra A Dichgans Martin M Wollenweber Frank A FA Zietemann Vera V Hoffmann Michael M Desmond David W DW Linden Thomas T Blomstrand Christian C Fagerberg Björn B Skoog Ingmar I Godefroy Olivier O Barbay Mélanie M Roussel Martine M Lee Byung-Chul BC Yu Kyung-Ho KH Wardlaw Joanna J Makin Stephen J SJ Doubal Fergus N FN Chappell Francesca M FM Srikanth Velandai K VK Thrift Amanda G AG Donnan Geoffrey A GA Kandiah Nagaendran N Chander Russell J RJ Lin Xuling X Cordonnier Charlotte C Moulin Solene S Rossi Costanza C Sabayan Behnam B Stott David J DJ Jukema J Wouter JW Melkas Susanna S Jokinen Hanna H Erkinjuntti Timo T Mok Vincent C T VC Wong Adrian A Lam Bonnie Y K BY Leys Didier D Hénon Hilde H Bombois Stéphanie S Lipnicki Darren M DM Kochan Nicole A NA

Study Outcome 

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Citations :  Román G.C. Science Press; London: 2003. Managing Vascular Dementia.
Authors :  68
Identifiers
Doi : 10.1016/j.dadm.2016.10.006
SSN : 2352-8729
Study Population
Male,Female
Mesh Terms
Other Terms
Cohort studies;Data harmonization;International consortium;Post-stroke dementia;Small vessel disease;Vascular cognitive disorder;Vascular dementia
Study Design
Cohort Study,Cross Sectional Study
Study Approach
Country of Study
Publication Country
United States