Staging of Schizophrenia With the Use of PANSS: An International Multi-Center Study.

Journal: The international journal of neuropsychopharmacology

Volume: 22

Issue: 11

Year of Publication: 2020

Affiliated Institutions:  rd Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Greece. Department of Medical and Health Sciences (IMH), Faculty of Health Sciences, Linköping University, Linköping, Sweden. University Psychiatric Centre KU Leuven, Kortenberg and Department of Neurosciences KU, Leuven, Belgium. University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry "Sveti Naum", Sofia, Bulgaria. Department of Psychiatry, Queen's University, Providence Care Hospital, Kingston, Ontario, Canada. National Institute of Mental Health, Klecany, Czech Republic. Department of Psychiatry, University of Turku, Turku, Finland. Department of Psychiatry, Sainte Marguerite University Hospital, Marseille, France. Department of Psychiatry, Ruhr University Bochum, LWL-University Hospital, Bochum, Germany. nd Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece. Department of Psychiatry, National and Kapodistrian University of Athens School of Medicine, Eginition Hospital, Athens, Greece. Nyírő Gyula Hospital, Budapest, Hungary. Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary. Western University, London Ontario, Canada. Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland. Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy. Department of Psychiatry and Narcology, Riga Stradins University, Riga, Latvia. Clinic of Psychiatric, Faculty of Medicine, Vilnius University, Vilnius, Lithuania. Clinical Department of Psychiatry, Clinical Centre of Montenegro, Podgorica, Montenegro. Department of Psychiatry, College of Medicine, University of Ibadan, Nigeria. Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland. Department of Psychiatry and Mental Health, Santa Maria University Hospital, Lisbon, Portugal. University of Medicine and Pharmacy of Târgu Mures, Romania. Samara State Medical University, Department of Psychiatry, Samara Psychiatric Hospital, Inpatient Unit, Russia. Institute of Mental Health, Belgrade, Serbia. Department of Psychiatry and Mental Health, University of Cape Town Cape Town, Western Cape, South Africa. Department of Psychiatry, University of Oviedo and Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Oviedo, Spain. Psychiatry Department, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey. Department of Psychiatry Lokmanya Tilak Municipal Medical College Mumbai, India. University of Medicine and Pharmacy of Timisoara, Romania. Institute of Mental Health, School of Medicine, University of Belgrade, Belgrade, Serbia. Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland. st Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Greece. MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa. Deakin University, IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Geelong, Australia. Deakin University, School of Medicine, IMPACT Strategic Research Centre, Barwon Health, Geelong, Australia. Department of Psychiatry, University of Florida, ***, FL. Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Abstract summary 

A specific clinically relevant staging model for schizophrenia has not yet been developed. The aim of the current study was to evaluate the factor structure of the PANSS and develop such a staging method.Twenty-nine centers from 25 countries contributed 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Analysis of covariance, Exploratory Factor Analysis, Discriminant Function Analysis, and inspection of resultant plots were performed.Exploratory Factor Analysis returned 5 factors explaining 59% of the variance (positive, negative, excitement/hostility, depression/anxiety, and neurocognition). The staging model included 4 main stages with substages that were predominantly characterized by a single domain of symptoms (stage 1: positive; stages 2a and 2b: excitement/hostility; stage 3a and 3b: depression/anxiety; stage 4a and 4b: neurocognition). There were no differences between sexes. The Discriminant Function Analysis developed an algorithm that correctly classified >85% of patients.This study elaborates a 5-factor solution and a clinical staging method for patients with schizophrenia. It is the largest study to address these issues among patients who are more likely to remain affiliated with mental health services for prolonged periods of time.

Authors & Co-authors:  Fountoulakis Konstantinos N KN Dragioti Elena E Theofilidis Antonis T AT Wikilund Tobias T Atmatzidis Xenofon X Nimatoudis Ioannis I Thys Erik E Wampers Martien M Hranov Luchezar L Hristova Trayana T Aptalidis Daniil D Milev Roumen R Iftene Felicia F Spaniel Filip F Knytl Pavel P Furstova Petra P From Tiina T Karlsson Henry H Walta Maija M Salokangas Raimo K R RKR Azorin Jean-Michel JM Bouniard Justine J Montant Julie J Juckel Georg G Haussleiter Ida S IS Douzenis Athanasios A Michopoulos Ioannis I Ferentinos Panagiotis P Smyrnis Nikolaos N Mantonakis Leonidas L Nemes Zsófia Z Gonda Xenia X Vajda Dora D Juhasz Anita A Shrivastava Amresh A Waddington John J Pompili Maurizio M Comparelli Anna A Corigliano Valentina V Rancans Elmars E Navickas Alvydas A Hilbig Jan J Bukelskis Laurynas L Injac Stevovic Lidija L Vodopic Sanja S Esan Oluyomi O Oladele Oluremi O Osunbote Christopher C Rybakowski Janusz Κ JΚ Wojciak Pawel P Domowicz Klaudia K Figueira Maria Luisa ML Linhares Ludgero L Crawford Joana J Panfil Anca-Livia AL Smirnova Daria D Izmailova Olga O Lecic-Tosevski Dusica D Temmingh Henk H Howells Fleur F Bobes Julio J Garcia-Portilla Maria Paz MP García-Alvarez Leticia L Erzin Gamze G Karadağ Hasan H De Sousa Avinash A Bendre Anuja A Hoschl Cyril C Bredicean Cristina C Papava Ion I Vukovic Olivera O Pejuskovic Bojana B Russell Vincent V Athanasiadis Loukas L Konsta Anastasia A Stein Dan D Berk Michael M Dean Olivia O Tandon Rajiv R Kasper Siegfried S De Hert Marc M

Study Outcome 

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Statistics
Citations :  Abrams R, Taylor MA, Gaztanaga P (1974) Manic-depressive illness and paranoid schizophrenia. A phenomenologic, family history, and treatment-response study. Arch Gen Psychiatry 31:640–642.
Authors :  81
Identifiers
Doi : 10.1093/ijnp/pyz053
SSN : 1469-5111
Study Population
Male,Female
Mesh Terms
Adult
Other Terms
illness course;outcome;schizophrenia;staging
Study Design
Exploratory Study,Cross Sectional Study
Study Approach
Country of Study
Publication Country
England