INTREPID II: protocol for a multistudy programme of research on untreated psychosis in India, Nigeria and Trinidad.

Journal: BMJ open

Volume: 10

Issue: 6

Year of Publication: 2021

Affiliated Institutions:  Health Service & Population Research department, Institute of Psychiatry Psychology and Neuroscience, London, UK. WHO Collaborating Centre for Research and Training in Mental Health, Neuroscience and Substance Abuse, Department of Psychiatry, University of Ibadan, Ibadan, Oyo, Nigeria. Schizophrenia Research Foundation, Chennai, India. Department of Psychiatry, The University of the West Indies at Saint Augustine Faculty of Medical Sciences, Saint Augustine, Tunapuna-Piarco, Trinidad and Tobago. Department of Epidemiology, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA. Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK. Department of Psychiatry, University of Ibadan College of Medicine, Ibadan, Oyo, Nigeria. Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, London, UK. Health Service & Population Research department, Institute of Psychiatry Psychology and Neuroscience, London, UK craig.morgan@kcl.ac.uk.

Abstract summary 

There are few robust and directly comparable studies of the epidemiology of psychotic disorders in the Global South. INTREPID II is designed to investigate variations in untreated psychotic disorders in the Global South in (1) incidence and presentation (2) 2-year course and outcome, (3) help-seeking and impact, and (4) physical health.INTREPID II is a programme of research incorporating incidence, case-control and cohort studies of psychoses in contiguous urban and rural areas in India, Nigeria and Trinidad. In each country, the target samples are 240 untreated cases with a psychotic disorder, 240 age-matched, sex-matched and neighbourhood-matched controls, and 240 relatives or caregivers. Participants will be followed, in the first instance, for 2 years. In each setting, we have developed and are employing comprehensive case-finding methods to ensure cohorts are representative of the target populations. Using methods developed during pilot work, extensive data are being collected at baseline and 2-year follow-up across several domains: clinical, social, help-seeking and impact, and biological.Informed consent is sought, and participants are free to withdraw from the study at any time. Participants are referred to mental health services if not already in contact with these and emergency treatment arranged where necessary. All data collected are confidential, except when a participant presents a serious risk to either themselves or others. This programme has been approved by ethical review boards at all participating centres. Findings will be disseminated through international conferences, publications in international journals, and through local events for key stakeholders.

Authors & Co-authors:  Roberts Tessa T Gureje Oye O Thara Rangaswamy R Hutchinson Gerard G Cohen Alex A Weiss Helen Anne HA John Sujit S Lee Pow Joni J Donald Casswina C Olley Bola B Miguel Esponda Georgina G Murray Robin M RM Morgan Craig C

Study Outcome 

Source Link: Visit source

Statistics
Citations :  Saha S, Chant D, McGrath J. A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time? Arch Gen Psychiatry 2007;64:1123–31. 10.1001/archpsyc.64.10.1123
Authors :  13
Identifiers
Doi : e039004
SSN : 2044-6055
Study Population
Male,Female
Mesh Terms
Case-Control Studies
Other Terms
epidemiology;mental health;schizophrenia & psychotic disorders
Study Design
Cohort Study,Cross Sectional Study
Study Approach
Country of Study
Niger
Publication Country
England