Impact of neoadjuvant chemotherapy in improving operative intervention in the management of cervical cancer in low resource setting: a preliminary report.

Journal: The Pan African medical journal

Volume: 36

Issue: 

Year of Publication: 2020

Affiliated Institutions:  Department of Obstetrics and Gynecology, College of Medicine, University of Nigeria, Ituku-Ozalla, Enugu, Nigeria. Department of Mental Health, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nigeria. Department of Family Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria.

Abstract summary 

There is paucity of data on interventions to improve cancer outcome in the low-resource setting. This study aims to determine the effect of Neoadjuvant Chemotherapy (NACT) in improving operative outcomes of cervical cancer. This was a longitudinal intervention study of patients diagnosed with FIGO stage IIB - IIIA cervical cancer that had NACT. Patients were re-evaluated after treatment with 4 cycles of chemotherapy for operability. McNemar test was used to determine changes in operability of the tumour. There was a significant difference in the number of patients that converted from inoperable to operable tumor post-chemotherapy. This study shows some promise for NACT for FIGO stage IIB - IIIA cancer of the cervix, especially in low-resource settings, where radiotherapy is scarce.

Authors & Co-authors:  Nwankwo Theophilus Ogochukwu TO Umeh Uchenna Anthony UA Aniebue Uzochukwu Uzoma UU Onu Justus Uchenna JU Umeh Chioma Roseline CR

Study Outcome 

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Statistics
Citations :  World Health Organization. Early diagnosis and screening. Cervical cancer. Accessed July 23 2020.
Authors :  5
Identifiers
Doi : 210
SSN : 1937-8688
Study Population
Male,Female
Mesh Terms
Aged
Other Terms
Neoadjuvant;cancer;cervical;chemotherapy;hysterectomy;radical
Study Design
Longitudinal Study,Cross Sectional Study
Study Approach
Country of Study
Publication Country
Uganda