Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry.
Journal: American journal of human genetics
Volume: 108
Issue: 4
Year of Publication: 2021
Affiliated Institutions: Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC , USA. Electronic address: migraff@email.unc.edu. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC , USA; Population Health Services, Geisinger Health, Danville, PA , USA. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC , USA. William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London ECM BQ, UK; Centre for Genomic Health, Life Sciences, Queen Mary University of London, London ECM BQ, UK. Vertex Pharmaceuticals Inc., Boston, MA , USA. Department of Biostatistics, Boston University School of Public Health, Boston, MA , USA. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA , USA. Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO , USA. Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD , USA. Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD , USA. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN , USA; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN , USA; Department of Thoracic Surgery, Vanderbilt University School of Medicine, Nashville, TN , USA. Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA , USA. Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY , USA. Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD , USA. Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX , USA. School of Public Health, University of Kentucky, Lexington, KY , USA. Framingham Heart Study, Boston University School of Medicine, Boston, MA , USA. Department of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ , USA. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA , USA; Department of Biostatistics, University of Washington, Seattle, WA , USA. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD , USA. Division of Biomarkers of Early Detection and Prevention, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA , USA. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI , USA. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN , USA; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN , USA; International Epidemiology Institute, Rockville, MD , USA. The Charles R. Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY , USA. Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC , USA; Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC , USA; Center for Diabetes Research, Wake Forest school of Medicine, Winston-Salem, NC , USA. Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA , USA. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA , USA. Department of Pediatrics, Section of Genomic Pediatrics, Medical College of Wisconsin, Milwaukee, WI , USA. Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC , USA. Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA , USA; Harvard Medical School, Boston, MA , USA. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN , USA; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN , USA. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA , USA. Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA , USA. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA , USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA , USA. Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA , USA. Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA , USA. Department of Public Health Sciences and Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA , USA. Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA , USA. Cancer Prevention Institute of California, Fremont, CA , USA. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA , USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA , USA; Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, LA , USA. Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, IL , USA. Department of Medicine, University of Vermont College of Medicine, Burlington, VT , USA. Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN , USA. Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC , USA. Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC , USA. Epidemiology Research Program, American Cancer Society, Atlanta, GA , USA. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC , USA. Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD , USA. Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria. Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI , USA. Center for Human Genetics, University of Texas Health Science Center at Houston, Houston, TX , USA. Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD , USA; Framingham Heart Study, Framingham, MA , USA; Division of Endocrinology and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, MA , USA. Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC , USA. National Institute on Aging, National Institutes of Health, Baltimore, MD , USA. Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD , USA. SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA , USA. Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA , USA; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia Research Institute, The Children's Hospital of Philadelphia, Philadelphia, PA , USA; Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA , USA. Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA , USA; Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA , USA; Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA , USA. Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA , USA. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD , USA. Department of Preventive Medicine, Stony Brook University, Stony Brook, NY , USA; Chronic Disease Research Centre and Faculty of Medical Sciences, University of West Indies, Bridgetown, Barbados; Ministry of Health, Bridgetown, Barbados. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD , USA. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA , USA; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA , USA; Department of Genetics, Harvard Medical School, Boston, MA , USA. Department of Health Disparities Research, Division of OVP, Cancer Prevention and Population Sciences, and Center for Community Implementation and Dissemination Research, Duncan Family Institute, The University of Texas MD Anderson Cancer Center, Houston, TX , USA. MedStar Research Institute, Hyattsville, MD , USA. Cancer Prevention Institute of California, Fremont, CA , USA; Department of Medicine, Stanford Prevention Research Center and Cancer Institute, Stanford, CA , USA. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL , USA; Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL , USA. Department of Public Health Sciences, University of Chicago, Chicago, IL , USA. Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL , USA. Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA , USA. Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN , USA. Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC , USA. Genetic Epidemiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD , USA. Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA , USA. Division of Health Equities, Department of Population Sciences, City of Hope Medical Center, Duarte, CA , USA. Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH , USA. Epidemiology Program, Cancer Research Center, University of Hawaii Cancer Center, Honolulu, HI , USA. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA , USA. Sickle Cell Center, Medical College of Georgia, Augusta University, Augusta, GA , USA. Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO , USA. Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC , USA. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD , USA; Data Tecnica Int'l, LLC, Glen Echo, MD , USA. Montreal Heart Institute, Montréal, QC HT C, Canada; Department of Medicine, Université de Montréal, Montréal, QC HT C, Canada. Department of Public Health Sciences, Henry Ford Health System, Detroit, MI , USA. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC , USA; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC , USA; Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC , USA. Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA , USA. Department of Medicine, Division of Cardiology, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC , USA. Department of Epidemiology, Brown University, Providence, RI , USA. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN , USA; The Charles R. Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY , USA. Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC , USA. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA , USA. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA , USA. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC , USA; The Center for Observational Research, Amgen, Inc., Thousand Oaks, CA , USA. Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA , USA. Department of Medicine, University of Mississippi Medical Center, Jackson, MS , USA. Center for Diabetes Research, Wake Forest school of Medicine, Winston-Salem, NC , USA. Department of Urology, Northwestern University, Chicago, IL , USA. Department of Medicine, University of Pennsylvania, Philadelphia, PA , USA. Montreal Heart Institute, Montréal, QC HT C, Canada. Department of Preventive Medicine, Stony Brook University, Stony Brook, NY , USA. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC , USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC , USA. Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, NY , USA. Department of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria. Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria. Centre for Population and Reproductive Health, College of Medicine, University of Ibadan, Ibadan, Nigeria. Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, IL , USA. Center for Health Policy and Health Services Research, Henry Ford Health System, Detroit, MI , USA. Slone Epidemiology Center, Boston University School of Medicine, Boston, MA , USA. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA , USA; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA , USA. Department of Biochemistry, School of Medicine, Wake Forest University, Winston-Salem, NC , USA. Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD , USA. Department of Medicine, University of Pittsburgh, Pittsburgh, PA , USA. Department of Urology, The University of Texas M.D. Anderson Cancer Center, Houston, TX , USA. Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA , USA. Division of Biostatistics, Washington University School of Medicine, St. Louis, MO , USA. Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL , USA. Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI , USA. Department of Family and Community Medicine, Meharry Medical College, Nashville, TN , USA. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY , USA. Department of Oncology, Wayne State University School of Medicine, Detroit, MI , USA; Karmanos Cancer Institute, Detroit, MI , USA. The New York Academy of Medicine, New York, NY , USA. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI , USA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI , USA. Division of Gastroenterology and Hepatology, University of Michigan Health System, Ann Arbor, MI , USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI , USA. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA , USA; Department of Epidemiology, University of Washington School of Public Health, Seattle, WA , USA. Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA , USA. Department of Epidemiology and Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY , USA. Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD , USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD , USA. Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN , USA. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY , USA. Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA , USA. Departments of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH , USA. Center for Health Policy and Health Services Research, Henry Ford Health System, Detroit, MI , USA; Department of Internal Medicine, Henry Ford Health System, Detroit, MI , USA. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS , USA. Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA , USA; Department of Urology, University of California, San Francisco, San Francisco, CA , USA. Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA , USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA , USA. Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA , USA; Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA , USA. MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB QQ, UK. School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX , USA. Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO , USA; BioData Catalyst Program, National Heart, Lung, and Blood Institute, Bethesda, MD , USA. Department of Biostatistics, Boston University School of Public Health, Boston, MA , USA; Framingham Heart Study, Boston University School of Medicine, Boston, MA , USA. The Charles R. Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY , USA; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY , USA; The Mindich Child Health Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY , USA. Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC , USA; Center for Diabetes Research, Wake Forest school of Medicine, Winston-Salem, NC , USA.
Abstract summary
Although many loci have been associated with height in European ancestry populations, very few have been identified in African ancestry individuals. Furthermore, many of the known loci have yet to be generalized to and fine-mapped within a large-scale African ancestry sample. We performed sex-combined and sex-stratified meta-analyses in up to 52,764 individuals with height and genome-wide genotyping data from the African Ancestry Anthropometry Genetics Consortium (AAAGC). We additionally combined our African ancestry meta-analysis results with published European genome-wide association study (GWAS) data. In the African ancestry analyses, we identified three novel loci (SLC4A3, NCOA2, ECD/FAM149B1) in sex-combined results and two loci (CRB1, KLF6) in women only. In the African plus European sex-combined GWAS, we identified an additional three novel loci (RCCD1, G6PC3, CEP95) which were equally driven by AAAGC and European results. Among 39 genome-wide significant signals at known loci, conditioning index SNPs from European studies identified 20 secondary signals. Two of the 20 new secondary signals and none of the 8 novel loci had minor allele frequencies (MAF) < 5%. Of 802 known European height signals, 643 displayed directionally consistent associations with height, of which 205 were nominally significant (p < 0.05) in the African ancestry sex-combined sample. Furthermore, 148 of 241 loci contained ≤20 variants in the credible sets that jointly account for 99% of the posterior probability of driving the associations. In summary, trans-ethnic meta-analyses revealed novel signals and further improved fine-mapping of putative causal variants in loci shared between African and European ancestry populations.Authors & Co-authors: Graff Mariaelisa M Justice Anne E AE Young Kristin L KL Marouli Eirini E Zhang Xinruo X Fine Rebecca S RS Lim Elise E Buchanan Victoria V Rand Kristin K Feitosa Mary F MF Wojczynski Mary K MK Yanek Lisa R LR Shao Yaming Y Rohde Rebecca R Adeyemo Adebowale A AA Aldrich Melinda C MC Allison Matthew A MA Ambrosone Christine B CB Ambs Stefan S Amos Christopher C Arnett Donna K DK Atwood Larry L Bandera Elisa V EV Bartz Traci T Becker Diane M DM Berndt Sonja I SI Bernstein Leslie L Bielak Lawrence F LF Blot William J WJ Bottinger Erwin P EP Bowden Donald W DW Bradfield Jonathan P JP Brody Jennifer A JA Broeckel Ulrich U Burke Gregory G Cade Brian E BE Cai Qiuyin Q Caporaso Neil N Carlson Chris C Carpten John J Casey Graham G Chanock Stephen J SJ Chen Guanjie G Chen Minhui M Chen Yii-Der I YI Chen Wei-Min WM Chesi Alessandra A Chiang Charleston W K CWK Chu Lisa L Coetzee Gerry A GA Conti David V DV Cooper Richard S RS Cushman Mary M Demerath Ellen E Deming Sandra L SL Dimitrov Latchezar L Ding Jingzhong J Diver W Ryan WR Duan Qing Q Evans Michele K MK Falusi Adeyinka G AG Faul Jessica D JD Fornage Myriam M Fox Caroline C Freedman Barry I BI Garcia Melissa M Gillanders Elizabeth M EM Goodman Phyllis P Gottesman Omri O Grant Struan F A SFA Guo Xiuqing X Hakonarson Hakon H Haritunians Talin T Harris Tamara B TB Harris Curtis C CC Henderson Brian E BE Hennis Anselm A Hernandez Dena G DG Hirschhorn Joel N JN McNeill Lorna Haughton LH Howard Timothy D TD Howard Barbara B Hsing Ann W AW Hsu Yu-Han H YH Hu Jennifer J JJ Huff Chad D CD Huo Dezheng D Ingles Sue A SA Irvin Marguerite R MR John Esther M EM Johnson Karen C KC Jordan Joanne M JM Kabagambe Edmond K EK Kang Sun J SJ Kardia Sharon L SL Keating Brendan J BJ Kittles Rick A RA Klein Eric A EA Kolb Suzanne S Kolonel Laurence N LN Kooperberg Charles C Kuller Lewis L Kutlar Abdullah A Lange Leslie L Langefeld Carl D CD Le Marchand Loic L Leonard Hampton H Lettre Guillaume G Levin Albert M AM Li Yun Y Li Jin J Liu Yongmei Y Liu Youfang Y Liu Simin S Lohman Kurt K Lotay Vaneet V Lu Yingchang Y Maixner William W Manson JoAnn E JE McKnight Barbara B Meng Yan Y Monda Keri L KL Monroe Kris K Moore Jason H JH Mosley Thomas H TH Mudgal Poorva P Murphy Adam B AB Nadukuru Rajiv R Nalls Mike A MA Nathanson Katherine L KL Nayak Uma U N'Diaye Amidou A Nemesure Barbara B Neslund-Dudas Christine C Neuhouser Marian L ML Nyante Sarah S Ochs-Balcom Heather H Ogundiran Temidayo O TO Ogunniyi Adesola A Ojengbede Oladosu O Okut Hayrettin H Olopade Olufunmilayo I OI Olshan Andrew A Padhukasahasram Badri B Palmer Julie J Palmer Cameron D CD Palmer Nicholette D ND Papanicolaou George G Patel Sanjay R SR Pettaway Curtis A CA Peyser Patricia A PA Press Michael F MF Rao D C DC Rasmussen-Torvik Laura J LJ Redline Susan S Reiner Alex P AP Rhie Suhn K SK Rodriguez-Gil Jorge L JL Rotimi Charles N CN Rotter Jerome I JI Ruiz-Narvaez Edward A EA Rybicki Benjamin A BA Salako Babatunde B Sale Michele M MM Sanderson Maureen M Schadt Eric E Schreiner Pamela J PJ Schurmann Claudia C Schwartz Ann G AG Shriner Daniel A DA Signorello Lisa B LB Singleton Andrew B AB Siscovick David S DS Smith Jennifer A JA Smith Shad S Speliotes Elizabeth E Spitz Margaret M Stanford Janet L JL Stevens Victoria L VL Stram Alex A Strom Sara S SS Sucheston Lara L Sun Yan V YV Tajuddin Salman M SM Taylor Herman H Taylor Kira K Tayo Bamidele O BO Thun Michael J MJ Tucker Margaret A MA Vaidya Dhananjay D Van Den Berg David J DJ Vedantam Sailaja S Vitolins Mara M Wang Zhaoming Z Ware Erin B EB Wassertheil-Smoller Sylvia S Weir David R DR Wiencke John K JK Williams Scott M SM Williams L Keoki LK Wilson James G JG Witte John S JS Wrensch Margaret M Wu Xifeng X Yao Jie J Zakai Neil N Zanetti Krista K Zemel Babette S BS Zhao Wei W Zhao Jing Hua JH Zheng Wei W Zhi Degui D Zhou Jie J Zhu Xiaofeng X Ziegler Regina G RG Zmuda Joe J Zonderman Alan B AB Psaty Bruce M BM Borecki Ingrid B IB Cupples L Adrienne LA Liu Ching-Ti CT Haiman Christopher A CA Loos Ruth R Ng Maggie C Y MCY North Kari E KE
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Citations : Wood A.R., Esko T., Yang J., Vedantam S., Pers T.H., Gustafsson S., Chu A.Y., Estrada K., Luan J., Kutalik Z., Electronic Medical Records and Genomics (eMEMERGEGE) Consortium. MIGen Consortium. PAGEGE Consortium. LifeLines Cohort Study Defining the role of common variation in the genomic and biological architecture of adult human height. Nat. Genet. 2014;46:1173–1186.Authors : 225
Identifiers
Doi : 10.1016/j.ajhg.2021.02.011SSN : 1537-6605