Building a national framework for multicentre research and clinical trials: experience from the Nigeria Implementation Science Alliance.

Journal: BMJ global health

Volume: 7

Issue: 4

Year of Publication: 2022

Affiliated Institutions:  Department of Health Sciences, Northeastern University, Boston, Massachusetts, USA. Center for Translation and Implementation Research (CTAIR), University of Nigeria, Nsukka, Enugu, Nigeria eezeanolue@gmail.com. Center for Translation and Implementation Research (CTAIR), University of Nigeria, Nsukka, Enugu, Nigeria. APIN Public Health Initiatives, Abuja, FCT, Nigeria. Institute of Human Virology Nigeria, Abuja, FCT, Nigeria. Caritas Nigeria, Abuja, FCT, Nigeria. Center for Integrated Health Programs (CIHP), Abuja, FCT, Nigeria. FHI, Abuja, FCT, Nigeria. National AIDS, Viral Hepatitis and Sexually Transmitted Infections Control Programme, Federal Ministry of Health, Abuja, FCT, Nigeria. National Cancer Control Programme, Federal Ministry of Health, Abuja, FCT, Nigeria. National Agency for the Control of AIDS (NACA), Abuja, FCT, Nigeria. Federal University of Health Sciences Otukpo, Otukpo, Benue State, Nigeria. Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA. Center for Mental Health Services Research, Brown School at Washington University in St Louis, St Louis, Missouri, USA. Department of Prevention and Community Health, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA. Department of Psychiatry, University of California, San Diego, La Jolla, California, USA. Center for Clinical Care and Clinical Research, Abuja, FCT, Nigeria.

Abstract summary 

There is limited capacity and infrastructure in sub-Saharan Africa to conduct clinical trials for the identification of efficient and effective new prevention, diagnostic and treatment modalities to address the disproportionate burden of disease. This paper reports on the process to establish locally driven infrastructure for multicentre research and trials in Nigeria known as the Nigeria Implementation Science Alliance Model Innovation and Research Centres (NISA-MIRCs). We used a participatory approach to establish a research network of 21 high-volume health facilities selected from all 6 geopolitical zones in Nigeria capable of conducting clinical trials, implementation research using effectiveness-implementation hybrid designs and health system research. The NISA-MIRCs have a cumulative potential to recruit 60 000 women living with HIV and an age-matched cohort of HIV-uninfected women. We conducted a needs assessment, convened several stakeholder outreaches and engagement sessions, and established a governance structure. Additionally, we selected and trained a core research team, developed criteria for site selection, assessed site readiness for research and obtained ethical approval from a single national institutional review board. We used the Exploration, Preparation, Implementation, Sustainment framework to guide our reporting of the process in the development of this network. The NISA-MIRCs will provide a nationally representative infrastructure to initiate new studies, support collaborative research, inform policy decisions and thereby fill a significant research infrastructure gap in Africa's most populous country.

Authors & Co-authors:  Olawepo John Olajide JO Ezeanolue Echezona Edozie EE Ekenna Adanma A Ogunsola Olabanjo O OO Itanyi Ijeoma Uchenna IU Jedy-Agba Elima E Egbo Emmanuel E Onwuchekwa Chukwudi C Ezeonu Alexandra A Ajibola Abiola A Olakunde Babayemi O BO Majekodunmi Omololuoye O Ogidi Amaka G AG Chukwuorji JohnBosco J Lasebikan Nwamaka N Dakum Patrick P Okonkwo Prosper P Oyeledun Bolanle B Oko John J Khamofu Hadiza H Ikpeazu Akudo A Nwokwu Uchechukwu Emmanuel UE Aliyu Gambo G Shittu Oladapo O Rositch Anne F AF Powell Byron J BJ Conserve Donaldson F DF Aarons Gregory A GA Olutola Ayodotun A

Study Outcome 

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Citations :  Institute for Health Metrics and Evaluation . Latest global disease estimates reveal perfect storm of rising chronic diseases and public health failures fueling COVID-19 pandemic. Available: http://www.healthdata.org/news-release/lancet-latest-global-disease-estimates-reveal-perfect-storm-rising-chronic-diseases-and [Accessed 15 Nov 2021].
Authors :  29
Identifiers
Doi : e008241
SSN : 2059-7908
Study Population
Male,Female
Mesh Terms
Africa South of the Sahara
Other Terms
Clinical trial;Cohort study;HIV;Maternal health;Public Health
Study Design
Cohort Study,Cross Sectional Study
Study Approach
Country of Study
Niger
Publication Country
England