Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium.
Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
Volume: 19
Issue: 8
Year of Publication: 2023
Affiliated Institutions:
The George Institute for Global Health, University of New South Wales, Sydney, Australia.
Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine and Health, UNSW Sydney, Sydney, Australia.
Center for Studies in Public Health and Aging Rene Rachou Institute, Oswaldo Cruz Foundation, Belo Horizonte, Brazil.
UConn Center on Aging, Department of Psychiatry, School of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA.
Department of Geriatric Psychiatry, Shanghai Mental Health Centre, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
Department of Epidemiology and Community Heath, Albert Einstein College of Medicine, Bronx, New York, USA.
Inserm U, IRD U, Univ. Limoges, CHU Limoges, EpiMaCT - Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France.
INM Institute for Neurosciences of Montpellier, Univ Montpellier, INSERM, Montpellier, France.
Department of Psychiatry and Neurochemistry, Center for Ageing and Health (Age Cap), University of Gothenburg, Gothenburg, Sweden.
st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
Lab of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Golgi Cenci Foundation, Abbiategrasso, Italy.
WHO Collaborating Centre for Research and Training in Mental Health, Neurosciences and Substance Abuse, Department of Psychiatry, University of Ibadan, Ibadan, Nigeria.
Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany.
Centre for Healthy Ageing and Wellness, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Alzheimer Centrum Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands.
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, San Francisco, California, USA.
Institute of Neurology, National Center for Neurological Disorders, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Center for Liberal Arts, Fukuoka Institute of Technology, Fukuoka, Japan.
Sports and Health Research Center, Department of Physical Education, Tongji University, Shanghai, China.
Global Health Nursing, Department of Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Gerontology Research Programme, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Queenstown, Singapore.
Instituto de Psiquiátria e LIM-, Hospital da Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Department of Medicine and Psychiatry, Universidad de Zaragoza, Zaragoza, Spain.
Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain.
Abstract summary
Sex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups.A total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models.Incident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs.Dementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men.
Authors & Co-authors:
Gong Jessica J
Harris Katie K
Lipnicki Darren M DM
Castro-Costa Erico E
Lima-Costa Maria Fernanda MF
Diniz Breno S BS
Xiao Shifu S
Lipton Richard B RB
Katz Mindy J MJ
Wang Cuiling C
Preux Pierre-Marie PM
Guerchet Maëlenn M
Gbessemehlan Antoine A
Ritchie Karen K
Ancelin Marie-Laure ML
Skoog Ingmar I
Najar Jenna J
Sterner Therese Rydberg TR
Scarmeas Nikolaos N
Yannakoulia Mary M
Kosmidis Mary H MH
Guaita Antonio A
Rolandi Elena E
Davin Annalisa A
Gureje Oye O
Trompet Stella S
Gussekloo Jacobijn J
Riedel-Heller Steffi S
Pabst Alexander A
Röhr Susanne S
Shahar Suzana S
Singh Devinder Kaur Ajit DKA
Rivan Nurul Fatin Malek NFM
Boxtel Martin van MV
Köhler Sebastian S
Ganguli Mary M
Chang Chung-Chou CC
Jacobsen Erin E
Haan Mary M
Ding Ding D
Zhao Qianhua Q
Xiao Zhenxu Z
Narazaki Kenji K
Chen Tao T
Chen Sanmei S
Ng Tze Pin TP
Gwee Xinyi X
Numbers Katya K
Mather Karen A KA
Scazufca Marcia M
Lobo Antonio A
De-la-Cámara Concepción C
Lobo Elena E
Sachdev Perminder S PS
Brodaty Henry H
Hackett Maree L ML
Peters Sanne A E SAE
Woodward Mark M
Study Outcome
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