Essential data dimensions for prospective international data collection in older age bipolar disorder (OABD): Recommendations from the GAGE-BD group.
Journal: Bipolar disorders
Volume: 25
Issue: 7
Year of Publication: 2024
Affiliated Institutions:
Department of Geriatric Psychiatry, Department of Psychiatry, Jewish General Hospital/Lady Davis Institute, McGill University, Montreal, Quebec, Canada.
Department of Psychiatry and Behavioral Neurosciences, McMaster University/St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.
Department of Psychiatry and Behavioral Sciences, University of Texas/McGovern Medical School, Houston, Texas, USA.
Department of Old Age Psychiatry, GGZ inGeest, Amsterdam, The Netherlands.
Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Medical School, University of Western Australia, Perth, Western Australia, Australia.
Selçuk University Medical Faculty, Department of Psychiatry, Mazhar Osman Mood Clinic, Konya, Turkey.
Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, CIBERSAM, Valencia, Spain.
Laboratório Interdisciplinar de Investigação Médica da Faculdad de Medicina, Universidad Federal de Minas Gerais, Belo Horizonte, Brazil.
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.
Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Division of Geriatric Psychiatry, McLean Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Laboratory of Neuroscience (LIM-), Department and Institute of Psychiatry, HCFMUSP, Faculdad de Medicina da Universidad de São Paulo, São Paulo, Brazil.
Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Bipolar and Depressive Disorders Unit, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
Department of Psychiatry, University of Sao Paulo, São Paulo, Brazil.
Department of Psychiatry, University of Toronto, Center for Addiction and Mental Health, Toronto, Ontario, Canada.
Federal Neuro-psychiatric Hospital Yaba, Lagos, Nigeria.
Division of Geriatric Psychiatry, McLean Hospital, Belmont, Massachusetts, USA.
Medical Faculty, Bipolar Center Wiener Neustadt, Sigmund Freud University, Wien, Austria.
Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Departments of Psychiatry and of Neurology, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Department of Psychiatry, University of California San Diego, San Diego, California, USA.
Abstract summary
By 2030, over 50% of individuals living with bipolar disorder (BD) are expected to be aged ≥50 years. However, older age bipolar disorder (OABD) remains understudied. There are limited large-scale prospectively collected data organized in key dimensions capable of addressing several fundamental questions about BD affecting this subgroup of patients.We developed initial recommendations for the essential dimensions for OABD data collection, based on (1) a systematic review of measures used in OABD studies, (2) a Delphi consensus of international OABD experts, (3) experience with harmonizing OABD data in the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD, n ≥ 4500 participants), and (4) critical feedback from 34 global experts in geriatric mental health.We identified 15 key dimensions and variables within each that are relevant for the investigation of OABD: (1) demographics, (2) core symptoms of depression and (3) mania, (4) cognition screening and subjective cognitive function, (5) elements for BD diagnosis, (6) descriptors of course of illness, (7) treatment, (8) suicidality, (9) current medication, (10) psychiatric comorbidity, (11) psychotic symptoms, (12) general medical comorbidities, (13) functioning, (14) family history, and (15) other. We also recommend particular instruments for capturing some of the dimensions and variables.The essential data dimensions we present should be of use to guide future international data collection in OABD and clinical practice. In the longer term, we aim to establish a prospective consortium using this core set of dimensions and associated variables to answer research questions relevant to OABD.
Authors & Co-authors:
Lavin Paola P
Rej Soham S
Olagunju Andrew T AT
Teixeira Antonio L AL
Dols Annemieke A
Alda Martin M
Almeida Osvaldo P OP
Altinbas Kursat K
Balanzá-Martínez Vicent V
Barbosa Izabela G IG
Blumberg Hilary P HP
Briggs Farren F
Calkin Cynthia C
Cassidy Kristin K
Forester Brent P BP
Forlenza Orestes V OV
Hajek Tomas T
Haarman Barthomeus C M BCM
Jimenez Esther E
Lafer Beny B
Mulsant Benoit B
Oluwaniyi Stephen O SO
Patrick Regan R
Radua Joaquim J
Schouws Sigfried S
Sekhon Harmehr H
Simhandl Christian C
Soares Jair C JC
Tsai Shang-Ying SY
Vieta Eduard E
Villa Luca M LM
Sajatovic Martha M
Eyler Lisa T LT
Study Outcome
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