New living evidence resource of human and non-human studies for early intervention and research prioritisation in anxiety, depression and psychosis.

Journal: BMJ mental health

Volume: 26

Issue: 1

Year of Publication: 2023

Affiliated Institutions:  Department of Psychiatry, University of Oxford, Oxford, UK andrea.cipriani@psych.ox.ac.uk. South African Medical Research Council/Stellenbosch University Extramural Genomics of Brain Disorders Unit, Department of Psychiatry, Stellenbosch University, Cape Town, South Africa. MQ, Mental Health Research, London, UK. Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland. Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. Institute for Implementation Science in Health Care, Faculty of Medicine, University of Zurich, Zurich, Switzerland. EPPI Centre, Social Research Institute, University College London, London, UK. UCL Centre for Behaviour Change, University College London, London, UK. Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine / School of Public Health, Kyoto, Japan. Chair, GALENOS Global Experiential Advisory Board, InHealth Associates, London, UK. Cochrane, London, UK. Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, ISCIII, School of Medicine, Universidad Complutense, Madrid, Spain. Department of Psychiatry and Psychotherapy, School of Medicine, Technical University of Munich, Munich, Germany. F, Research Ltd, London, UK. Department of Psychiatry, University of Oxford, Oxford, UK. Department of Psychiatry, Istanbul Medeniyet University, Turkey, Turkey. Wellcome, London, UK. Cochrane Australia, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

Abstract summary 

In anxiety, depression and psychosis, there has been frustratingly slow progress in developing novel therapies that make a substantial difference in practice, as well as in predicting which treatments will work for whom and in what contexts. To intervene early in the process and deliver optimal care to patients, we need to understand the underlying mechanisms of mental health conditions, develop safe and effective interventions that target these mechanisms, and improve our capabilities in timely diagnosis and reliable prediction of symptom trajectories. Better synthesis of existing evidence is one way to reduce waste and improve efficiency in research towards these ends. Living systematic reviews produce rigorous, up-to-date and informative evidence summaries that are particularly important where research is emerging rapidly, current evidence is uncertain and new findings might change policy or practice. Global Alliance for Living Evidence on aNxiety, depressiOn and pSychosis (GALENOS) aims to tackle the challenges of mental health science research by cataloguing and evaluating the full spectrum of relevant scientific research including both human and preclinical studies. GALENOS will also allow the mental health community-including patients, carers, clinicians, researchers and funders-to better identify the research questions that most urgently need to be answered. By creating open-access datasets and outputs in a state-of-the-art online resource, GALENOS will help identify promising signals early in the research process. This will accelerate translation from discovery science into effective new interventions for anxiety, depression and psychosis, ready to be translated in clinical practice across the world.

Authors & Co-authors:  Cipriani Andrea A Seedat Soraya S Milligan Lea L Salanti Georgia G Macleod Malcolm M Hastings Janna J Thomas James J Michie Susan S Furukawa Toshi A TA Gilbert David D Soares-Weiser Karla K Moreno Carmen C Leucht Stefan S Egger Matthias M Mansoori Parisa P Barker James M JM Siafis Spyridon S Ostinelli Edoardo Giuseppe EG McCutcheon Robert R Wright Simonne S Simpson Matilda M Elugbadebo Olufisayo O Chiocchia Virginia V Tonia Thomy T Elgarf Rania R Kurtulmus Ayse A Sena Emily E Simple Ouma O Boyce Niall N Chung Sophie S Sharma Anjuli A Wolpert Miranda M Potts Jennifer J Elliott Julian H JH

Study Outcome 

Source Link: Visit source

Statistics
Citations :  GBD 2019 Mental Disorders Collaborators . Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Psychiatry 2022;9:137–50. 10.1016/S2215-0366(21)00395-3
Authors :  34
Identifiers
Doi : e300759
SSN : 2755-9734
Study Population
Male,Female
Mesh Terms
Humans
Other Terms
Adult psychiatry;Anxiety disorders;Child & adolescent psychiatry;Depression & mood disorders;Schizophrenia & psychotic disorders
Study Design
Cross Sectional Study
Study Approach
Systemic Review
Country of Study
Publication Country
England